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Taschenbuch. Zustand: Neu. Neuware - Seeing Stars is written for astronomers, regardless of the depth of their theoretical knowledge, who are taking their first steps in observational astronomy. Chris Kitchin and Bob Forrest - both professional astronomers - take a conducted tour of the night sky and suggest suitable observing programmes for everyone from beginners to experts. How is this book different We are all familiar with the beautiful images of planets and galaxies obtained by spacecraft and giant telescopes - but what can you really see with a small telescope What should you expect from a small refractor or reflector And what is the effect of observing from a site near a city The answers are all here, with many photographs that will illustrate exactly what can be seen with different instruments (everything from the naked eye to a 300mm telescope) - and from different locations.…

Taschenbuch. Zustand: Neu. Neuware - ACE inhibitors are one of the most exciting and interesting of recent medical developments. They fit the patho-physiologica1 processes of cardiovascular disease with fascinating precision and are a constant stimulus to the acquisition of greater understanding of the mechanisms involved and of the mode of action of the drugs themselves. There is still much to be learned, especially about the wider effects of the drugs, their precise mode and site of action and about differences between the different preparations. ACE inhibitors are of proven benefit to patients with chronic congestive heart failure and are the latest in the series of drugs used in the treatment of hypertension. Interest in the treatment of hypertension has paralleled the development of hypotensive drugs and the realisation that long-term prognosis could be significantly improved. The treatment of hypertension has progressed in stages following the development of a succession of increasingly effective drugs, each allowing a greater proportion of patients to be treated with fewer and fewer side-effects. First, the ganglion-blocking agents such as hexamethonium and guan ethidine transformed the outlook for patients with malignant hypertension but proved too unpleasant for routine use in other forms of hypertension.…

Taschenbuch. Zustand: Neu. Neuware.

Taschenbuch. Zustand: Neu. Neuware - This monograph contains the proceedings from the Advanced Study Institute on 'Vascular Endothelium: Physiological Basis of Clinical Problems' which took place in Corfu, Greece in June 1990. The meeting consisted of twenty-eight lectures, most of them adapted as full length papers in this volume, as well as numerous short oral and poster communications which are abstracted and also included in alphabetical order (pages 239-302). There were ninety-six participants from ten NATO and four other European countries. The meeting was the second in as many years dealing with a specific subject in Endothelial Cell biology. Following the 1988 discussion on 'Receptors and Transduction Mechanisms', the present ASI recognized and tried to deal with the increasing overlap in interest between basic scientists studying endothelial cell functions and clinicians facing problems of known or suspected endothelial pathological involvement. As with any similar effort, we opted to be selective, rather than fail by trying to be inclusive, in the subjects covered. We chose to discuss diseases, such as atherosclerosis, sepsis, ARDS and stroke, based on their relevance to endothelial cell function and urgent need for new insights into their pathogenesis and treatment. Similarly, we examined endothelial cell functions by considering their relevance to disease and their potential for elucidating important pathologies. Obviously, some areas were covered superficially or not at all; this should not distract from their importance, but rather reflect on the constraints of time and -not at all negligibly -the bias of the organizing committee.…

Taschenbuch. Zustand: Neu. Neuware - The patterns of land use that have evolved in Europe reflect the boundaries set by the natural environment and socio-economic responses to the needs of the population. Over the centuries man has been able to overcome increasingly the constraints placed on land use by the natural environment through the development of new technologies and innovations, driven by an increasing population and rising material expectations. However, activities are still ultimately constrained by natural limitations such as climatic characteristics and associated edaphic and vegetational features. A major problem for land management, in its broadest sense, can be a reluctance to foresee the consequent ecological changes. This means that mitigating strategies will not be implemented in time to prevent environmental degradation and social hardship, although in many parts of Europe, over some centuries, demands have been met in a sustainable way, by sound, prudent and temperate expectations that have dictated management regimes. The management of land in Europe has always been a complex challenge: land is the primary, though finite resource. DeciSions regarding the use of land and manipulation of ecosystem dynamics today may affect the long-term primary productivity of the resource. Decisions to change land use may be virtually irreversible; urbanization is an illustration of the influence of population density on the land resource.…

Taschenbuch. Zustand: Neu. Neuware - The present volume is a continuation of Volume 8 in the Annals series. Together Volumes 8 and 9 are intended to show the contribu tion of history to theory in psychology. The reader is referred to the Introduction by Hans Rappard and Pieter van Strien, and the Preface in Volume 8 that serve as a prelude to the papers included in both volumes. Volume 8 includes three major papers: Psychological objects, practice, and history by Kurt Danziger, with commentaries by Mitchell Ash, Franz Samelson, and John Mills; History and the psychological imagination by Irmingard Staeuble, with commentar ies by Carl Graumann and Roger Smith; and The historical practice of theory construction by Pieter 1. van Strien, with commentaries by Helmut Luck, Kenneth Gergen, and Ian Lubek. Similarly, the present volume includes three major papers and ten commentaries. In preparation of this volume and its companion, Volume 8, we gratefully acknowledge the assistance of Valerie Welch who entered the text, and Casey Boodt who proofread the text and prepared the indexes. Leendert P. Mos and William J. Baker June, 1993 vii Contents Chapter 1. History and system . . . . . . . . . . . . . . . . . . . . 1 . . . Hans V Rappard Psychology as its history . . . . . . . . . . . . . . . . . . . 41 Daniel N. Robinson Theoretical psychology, systematology, and phenomenological variation. . . . . . . . . . . . . . . . . . . . . 47 . Eckart Scheerer Systematization and history. . . . . . . . . . . . . . . . . . . . . 63 K. B. Madsen Towards the remarriage of theoretical psychology and psychology: Reply to commentators. . . . . . . . . . . . . . . . 67 Hans V Rappard Chapter 2.…

Taschenbuch. Zustand: Neu. Neuware - Oil is the lifeblood of the global economy, and its misuse carries the risk of heavy economic and environmental penalties. This book is a collection of essays bearing on economic growth and environmental concerns for a world that will continue to be dependent on oil throughout the next century. Topics include the outlook for petroleum demand and supply, the potential for alternatives to a petroleum-based economy, the costs of controlling automobile emissions, the environmental costs of moving oil by tanker and pipeline, and competition issues in the production and distribution of petroleum products. The wide range of topics reflects the many different ways in which petroleum and use affect the quality of our lives. The essays are the end results of an initiative by the University of California Energy Institute and reflect careful research into the costs and benefits of the petroleum economy. Together, they offer new insights into the critical task of living with oil, for today and for the future.…

Taschenbuch. Zustand: Neu. Neuware - This book includes the most significant contributions of the 3rd International Symposium on MULTIPLE RISK FACTORS IN CARDIOVASCULAR DISEASE held in Florence, Italy, July 6-9, 1994. The meeting focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological evidence that individuals from industrialized countries often possess two or more risk factors which synergistically increase the global risk profile. This has become more evident in recent years with the increase in life expectancy of the general population. The evidence that in high risk patients, a combination of risk factors often is detected, is highlighted in these Proceedings. Many recent epidemiological data identifYing the intrinsic and environmental factors contributing to the development of atherosclerosis are discussed. These results, in parallel with basic and clinical research, underline how atherosclerosis is a complex and multifactorial process involving the influences of lipids, including lipoprotein subfractions, blood pressure, rheologic forces, carbohydrate tolerance, and thrombogenic factors. Furthermore, the risk associated with anyone of these risk factors varies widely depending on level of the associated atherogenic risk factors.…

Taschenbuch. Zustand: Neu. Neuware - Advances in Clinical Child Psychology is a serial publication designed to bring together original summaries of the most important new develop ments in the field of clinical psychology and its related disciplines. Each chapter is written by a key figure in an innovative area of research or by an individual who is particularly well qualified to comment on a topic of major contemporary importance. These chapters provide convenient, concise explorations of empirical and clinical advances in the fields of clinical child psychology, child psychiatry, and related disciplines. The chapter topics are chosen by the editors and are based on sug gestions by the advisory editors, unsolicited suggestions provided by colleagues, and all of our reading of the latest published empirical and theoretical works. They reflect our collective perception of the leading trends in the field of clinical child psychology. The contents of Volume 10 reflect multiple themes. Two chapters focus on different aspects of the child's family: the home and family environment associated with childhood psychopathology and the characteristics of parents whose parenting has become twisted into the abuse or neglect of their own children. The key topics of aggression and stealing are dealt with in two chapters, and five chapters deal with the variety of topics that were formerly under the umbrella concept of minimal brain dysfunction.…

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Taschenbuch. Zustand: Neu. Neuware.

Taschenbuch. Zustand: Neu. Neuware - The present volume is based upon the invited review lectures delivered to the European Brain and Behaviour Society's Workshop on Recovery of Function Following Brain Damage held at Goldsmiths' College, University of London, in April 1991. Coming exactly ten years after the Society's ftrst meeting on this subject, held at Erasmus University, Rotterdam, a major objective of the Workshop was to review progress in the intervening years. This task was begun by Professor D. G. Stein in his opening presentation. Looking ahead to possible developments in recovery research in the next decade was the subject of Professor B. Kolb's closing lecture. The intervening presentations reviewed progress made in speciftc areas of recovery research. In addition to reviewing progress over the last decade we sought to achieve an additional objective in the way that the invited review lectures were organised. This was to bring together those doing basic research, usually animal research, and those whose of the lectures were 'paired', research interests are more clinically orientated. Thus some one concentrating on the results of animal studies and one on clinical research findings.…

Taschenbuch. Zustand: Neu. Neuware - This monograph is intended to compile the lectures presented at the 4th Annual Symposium 'Cardiac Surgery:1992' held at the Frenchman's Reef Beach Resort, St. Thomas, US Virgin Islands, November 7-10, 1991. This symposium was organized by the Division of Cardiothoracic Surgery and the School of Cardiovascular Perfusion, Cooper Hospital/University Medical Center, Camden, New Jersey and sponsored by the University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Philadelphia Academy of Cardiovascular Perfusion and the American Society of Extracorporeal Technology -Region II. The symposium was devoted to cardiothoracic surgeons, cardiologists, cardiovascular perfusionists, and nurses involved in the management of the cardiac surgical patient. Therefore, the context of the book represents the multidisciplinary nature of cardiac surgery at its present level of development. The contributors to this book have critically examined their experience and discussed controversial issues regarding cardiac pathophysiology, surgical indications, operative techniques, and long term care and outcome. The co-editors wish to express their gratitude for the contributors' efforts in the production of this manuscript. We would also like to thank the members of the Organizing Committee, Jane V. Stewart MSN, RN, CCRN, Roger A. Vertrees BA, CCP, Rosemary Volosin, MSN, RN, Rosemary Morrone and Paul R. Cappola BS, CCP, who have greatly contributed to the success of the symposium.…

Taschenbuch. Zustand: Neu. Neuware - The First International Cryogenic Materials Conference (ICMC) provided a new forum for the presentation of low-temperature materials research. The confer ence, held in conjunction with the 1975 Cryogenic Engineering Conference, provided materials research personnel with excellent exposure to current develop ments in the cryogenics field and beneficial interactions with designers of cryogenic systems. Because of the large response to a late call for papers, the enthusiasm and encouragement at the meeting, and the wide spectrum and high quality of papers, the Second International Cryogenic Materials Conference is being planned along with the 1977 Cryogenic Engineering Conference for Boulder, Colorado, in the summer of 1977. The success of the First International Cryogenic Materials Conference was certainly in large measure due to the excellent hospitality of our Canadian hosts, the Royal Military College of Canada and Queen's University in Kingston, Ontario. In particular, the efforts of A. C. Leonard and his staff ensured an excellent conference and a pleasant and memorable visit to Canada. The Cryogenic Engineering Conference Board was both generous and skillful in helping to initiate this new conference and their guidance and acceptance is gratefully acknowledged. The Cryogenic Engineering Conference program chairman, M. J. Hiza, greatly facilitated the interaction for the two conferences and provided valuable assistance in generat ing a workable program. The proceedings of the 1975 Cryogenic Engineering Conference are published as Volume 21 of the Advances in Cryogenic Engineering and include many papers indicating innovative use of new cryogenic materials properties data.…

Taschenbuch. Zustand: Neu. Neuware - Volume 2 of Contnnporary Xephrology updates the major developments which ha'e occurred during the past 2 years in 15 major areas of both basic and clinical nephrology. In addition, this volume has a section, Chapter 8, uitten by Drs. Pederson, Llach, and Papper, from the Med ical School at the Universitv of Oklahoma, which reviews the recent developments on nonilwasive diagnostic techniques in nephrology. The other chapters are presented in such a way as to emphasize the major advances that have occurred in the different areas in the last 2 years. In Chapter 1, Dr. Schafer analyzes in detail the new information available regarding the action of aldosterone both in anuran membranes and in the mammalian kidney. Drs. Knox and Romero, in Chapter 2, update the information accrued du ring the last 2 years in the area of renal hemodynamics and sodium chloride excretion. In the area of renal me tabolism (Chapter 3), Schoolwerth, Little, and Idell-Wenger review in detail the metabolism of lipids in the kidney and its potential relation to renal function. This is, to the best of our knowledge, the first compre hensive review of this subject in any textbook of nephrology. Dr. Dunn provides an authoritative review of the major advances in the rapidly expanding field of prostaglandins with particular emphasis on renal prostaglandins (Chapter 4). Drs. Batlle and Kurtzman update new con cepts of acid-base phvsiology and pathophysiology, and Dr. …

Taschenbuch. Zustand: Neu. Neuware - It is necessary to realize that the term 'photosynthetic prokaryotes' encom passes the widest and most diverse grouping of bacteria, but in itself has no taxonomic or phylogenetic significance. It means those organisms, other than eukaryotes, which require, obligately or facultatively, light for growth. The re cent application 16S rRNA sequencing to microbial phylogeny, asso ciated mainly with the work of Woese, emphasizes the evolutionarily dis persed nature of purpIe and green photosynthetic bacteria as weIl as the rather coherent phylogenetic connections of the cyanobacteria. It is not surprising, therefore, that a volume such as this which seeks to give an introduction to this collection of organisms must be highly selective; ac cordingly, several important features are discussed only superficiaIly, e. g. , differentiation, life cycles, and biochemical aspects of nutrition. Rather, we have attempted to provide adescription of the essential features which are common and those which are characteristic, e. g. , the physiology of photo synthesis and ecological distribution. Bearing in mind the aim of the series, we have asked our authors to emphasize aspects of the importance of these organisms in nature and their industrial applications. As will be seen from the text, these organisms have an ancient history in 'biotechnology,' having been used as foodstuffs by several cultures, but their exploitation has been limited to their natural patterns and products of growth. …

Taschenbuch. Zustand: Neu. Neuware - The papers in this volume are in honor of Bowman L. Clarke. Bowman Clarke earned degrees from Millsaps College, the University of Mississippi, and Emory University in Atlanta, Georgia, including the PhD in philosophy from Emory in 1961. He spent most of his academic career, a total of twenty-nine years, as a member of the Philosophy Department of the University of Georgia, Athens, Georgia, from which he retired in 1990. He also served as Head of the Department for several years. He has held many positions of distinction in professional societies, including President of the Georgia Philosophical Society, President of the Society for the Philosophy of Religion, and President of the Southern Society for Philosophy and Psychology. He also served as Editor-in Chief of the International Journal for the Philosophy of Religion from 1975-1989. Professor Clarke is the author of Language and Natural Theology (The Hague: Mouton and Co. , 1966) as well as numerous articles in professional journals. He has made major contributions in the areas of the philosophy of religion, the study of the philosophy of Alfred North Whitehead, and the development of the calculus of individuals. ix J. F. Harris (ed. ), Logic, God and Metaphysics, ix. 1992 Kluwer Academic Publishers. Introduction The title for this volume, Logic, God, and Metaphysics, was chosen very carefully and deliberately. The papers in this volume are directed at the issues and problems which lie in the domain of the juncture of these three different areas of philosophical inquiry.…

Taschenbuch. Zustand: Neu. Neuware - 'Et moi, . , si j'avait su comment en revenir, je One service mathematics bas rendered the human race. It bas put common sense back n'y serais point all~.' where it belongs, on the topmost shelf next to lu1esVeme the dusty canister labelled 'discarded nonsense'~ Eric T. Bell 1be series is divergent; therefore we may be able to do something with it O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and nonlineari ties abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sci ences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One ser vice topology has rendered mathematical physics . '; 'One service logic has rendered computer science . .'; 'One service category theory has rendered mathematics . .'. All arguably true. And all statements obtainable this way form part of the raison d 'etre of this series.…

Taschenbuch. Zustand: Neu. Neuware - From the President of the Research Society on Alcoholism Alcohol research has entered an era of growth which brings enhanced opti mism regarding the elucidation of the biochemical and psychosocial factors which combine to produce the phenomena of alcohol abuse and alcoholism. The solidification of knowledge regarding the genetic determinants of certain alcohol-related problems puts on firm footing the biological approaches for developing solutions to these problems. The current volume of Recent Devel opments in Alcoholism contains an excellent blend of information both on stud ies assessing the behavioral and physiological variables which may be ge netically linked to an individual's risk of developing problems with alcohol, and on clinical and basic science investigations of the pathological conse quences of excessive ethanol ingestion. Further progress in the alcoholism research area will continue to require investigation of the interactions of en vironmental variables with the genetically determined biology of an individ ual. Novel techniques in the fields of molecular genetics, physical chemistry, and behavioral pharmacology are being brought to bear on the central issues in the field, and the addition of these tools to the science of alcohol research brings closer the prospect of fruitful clinical application of our basic knowl edge. The Research Society on Alcoholism remains devoted to the task of promoting the generation of knowledge regarding the actions of alcohol and the mechanisms which produce alcohol abuse and alcoholism.…

Taschenbuch. Zustand: Neu. Neuware - Montreal has had a longstanding interest in somatostatin. Two years ago when the final planning began for the International Con gress of Endocrinology in Quebec City in July 1984, we seized the op portunity for having a separate Satellite Symposium on somatostatin here in Montreal. We felt that after a decade of uniformly vigorous growth in somatostatin research, the opportune moment had arrived for a review of the most significant past developments and for setting the directions for the future. Knowing the futility of trying to cover every aspect of the burgeoning somatostatin field in a two day scientific program, we opted for a detailed analysis of selected areas which were reasonably mature and of areas of greatest new activity. To attain these objectives, 27 leading international experts actively involved in their fields were invited to present an indepth review of their work in one of five major categories of somatostatin research. Thirty minutes at the end of each session were assigned for a three way, comprehensive discussion of some of the core concepts between the session moderators, the panellists and the audience. The feedback that we have received from the particip ants leaves little doubt that the meeting was a scientific and social success. This book fulfills our final commitment towards the Meeting which was to record the proceedings in a timely publication.…

Taschenbuch. Zustand: Neu. Neuware - In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.…

Taschenbuch. Zustand: Neu. Neuware - Bernard R. Gifford and Linda C. Wing Standardized testing has become a ubiquitous feature of American life. As a major source of information for reducing uncertainty in the alJocation of merit based educational, training, and employment opportunities, testing affects the life chances of individuals. Moreover, testing inOuences the way in which our societyjudgesitselfandprovides for ourcollective future. Test scores may determine a child's admission to lcindergarten and promotion to the fIrst grade. Most states award the high school diploma only ifa student has passed a minimum competency test. Major institutions of higher education typically require applicants to supplement their records of academic achievement with scores on college admissions tests. In the labor market, as a condition of employment or assignment to training programs, more and more employers are requiring workers to sit for personnel selection tests. Additionally, it has become commonplace to use test scores to calibrate our national sociopolitical condition and our capacity to compete with other countries in the global economy. In short, with increasing frequency and intensity, scores on examinations that purport to be objective and precise measures of individual knowledge, abilities, and potential are playing a critical role in the opportunity marketplace. Similarly, test scores are exercising growing influence in assessments of our social and economic institutions and in policy decisions about the relative invesunents that should be made in each. In all these instantiations, test scores are at the center of high-stakes decision making about the future of individuals and of the nation itself.…

Taschenbuch. Zustand: Neu. Neuware - In summary, the technical, scientific and medical aspects of transfusion me dicine continue to be critical. We all must find ways to provide a safer unit of blood and blood components. However, there must be a realization by all in volved in the profession that the management and administration aspects of transfusion medicine deserve equal attention, respect and support. Why It is very simple! Without all aspectsoftransfusion medicine working togetherfor the common good - care ofthe patient - we will all fail. References 1. Standards for Blood Banks and Transfusion Services, American Association of Blood Banks, 14th edition, Arlington, VA, USA, 1991. 2. Blood Assurance Act of 1979 (S.161O), Senator Richard S. Schweiker, United States Senate, Washington, DC, USA, July 31,1979. 3. Administrative Guidelines for Blood Banks, American Association of Blood Banks, Arlington, VA, 1989. 4. 'You're absolutely right: We goofed'. Howard Upton, Southwest Airlines Spirit, September 1991:24. 5. Administrative Manual, Volume II, American Association of Blood Banks, Arlington, VA, USA, 1987.…

Taschenbuch. Zustand: Neu. Neuware - Sixteen volumes and one supplement have now appeared in the series known as Evolutionary Biology. The editors continue to seek critical re views, original papers, and commentaries on controversial topics. It is our aim to publish papers primarily of greater length and depth than those normally published by society journals and quarterlies. The editors make every attempt to solicit manuscripts on an international scale and to see that every facet of evolutionary biology-classical or modern-is cov ered. Manuscripts should be sent to anyone of the following: Max K. Hecht, Department of Biology, Queens College of the City University of New York, Flushing, New York 11367; Bruce Wallace, Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061; Ghillean T. Prance, New York Botanical Garden, Bronx, New York 10458. The Editors vii Contents 1. Darwinian Selection of Self-Replicating RNA Molecules 1 Christ(~r K. Biehricher Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Replication of Virus RNA in Vitro. . . . . . . . . . . . . . . . . . . . . . . . 2 Extracellular Darwinian Experiments. . . . . . . . . . . . . . . . . . . . . . 5 Characterization of the QI3 Replicase. . . . . . . . . . . . . . . . . . . . . . 9 Nonviral RNA Templates of QI3 Replicase. . . . . . . . . . . . . . . . . . II The Mechanism of RNA Replication . . . . . . . . . . . . . . . . . . . . . . 14 Initiation of Replication and Template Specificity . . . . . . . . . . . 14 Mechanism of Replica Chain Elongation. . . . . . . . . . . . . . . . . . 17 Termination of Replication. . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Replication of RNA Variants . . . . . . . . . . . . . . . . . . . . . . . . . . 21 TheQuasispecies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 De NOl'O Synthesis of Self-Replicating RNA. . . . . . . . . . . . . . . . . 27 The Mechanism of Selection . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 Selection in the Exponential Growth Phase. . . . . . . . . . . . . . . . 32 Selection in the Linear Growth Phase. . . . . . . . . . . . . . . . . . . . 35 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Appendix I. Replication. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Appendix II. The Quasispecies. . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Appendix III. Selection under Various Conditions . . . . . . . . . . . . 44 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .…

Taschenbuch. Zustand: Neu. Neuware - Artificial Neural Networks have captured the interest of many researchers in the last five years. As with many young fields, neural network research has been largely empirical in nature, relyingstrongly on simulationstudies ofvarious network models. Empiricism is, of course, essential to any science for it provides a body of observations allowing initial characterization of the field. Eventually, however, any maturing field must begin the process of validating empirically derived conjectures with rigorous mathematical models. It is in this way that science has always pro ceeded. It is in this way that science provides conclusions that can be used across a variety of applications. This monograph by Michael Lemmon provides just such a theoretical exploration of the role ofcompetition in Artificial Neural Networks. There is 'good news' and 'bad news' associated with theoretical research in neural networks. The bad news isthat such work usually requires the understanding of and bringing together of results from many seemingly disparate disciplines such as neurobiology, cognitive psychology, theory of differential equations, largc scale systems theory, computer science, and electrical engineering. The good news is that for those capable of making this synthesis, the rewards are rich as exemplified in this monograph.…

Taschenbuch. Zustand: Neu. Neuware - Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. As a consequence, our knowledge of the role of these receptors in physiology and pathology continues to grow at a fast pace and PPARs have become an interesting target for the treatment of many pathological conditions, including diabetes and atherosclerosis. This volume provides an authoritative view of the current clinical and scientific developments within this evolving area of study.…

Taschenbuch. Zustand: Neu. Neuware - Four years ago we began soliciting articles for this volume from authors who were engaged in comprehensive research on whales. From the outset we decided not to limit the subject matter to behavior but to also include natural history. Much of what is known about the behavior of whales arose from studies whose principal aim was not behavior, much as it did for other animal groups before behavior was considered a distinct discipline. Thus in many of the articles behavior is closely intertwined with natural history and in others is completely overshadowed by a basic natural history approach. Our aim was to have the articles contain a review of the literature and include research findings not previously published. For all intents and purposes this aim has been realized, albeit perhaps not in as balanced a fashion in terms of species or subject matter as was originally planned. Nevertheless, we believe the articles present a wide range of informative works with a myriad of approaches and techniques represented. We are grateful to the contributors for their patience and understanding in awaiting publication, which has taken much longer than we originally expected. We are also grateful tor the assistance of a number of people, especially Julie Fischer and Lois Winn for their editorial efforts, and Jill Grover, Carol Samet, and Lois Winn for their help in indexing.…

Taschenbuch. Zustand: Neu. Neuware - This IMA Volume in Mathematics and its Applications DEGENERATE DIFFUSIONS is based on the proceedings of a workshop which was an integral part of the 1990- 91 IMA program on 'Phase Transitions and Free Boundaries'. The aim of this workshop was to provide some focus in the study of degenerate diffusion equations, and by involving scientists and engineers as well as mathematicians, to keep this focus firmly linked to concrete problems. We thank Wei-Ming Ni, L.A. Peletier and J.L. Vazquez for organizing the meet ing. We especially thank Wei-Ming Ni for editing the proceedings. We also take this opportunity to thank those agencies whose financial support made the workshop possible: the Army Research Office, the National Science Foun dation, and the Office of Naval Research. A vner Friedman Willard Miller, Jr. PREFACE This volume is the proceedings of the IMA workshop 'Degenerate Diffusions' held at the University of Minnesota from May 13 to May 18, 1991.…

Taschenbuch. Zustand: Neu. Neuware - After long years of work that have seen little industrial application, high-level synthesis is finally on the verge of becoming a practical tool. The state of high-level synthesis today is similar to the state of logic synthesis ten years ago. At present, logic-synthesis tools are widely used in digital system design. In the future, high-level synthesis will play a key role in mastering design complexity and in truly exploiting the potential of ASIes and PLDs, which demand extremely short design cycles. Work on high-level synthesis began over twenty years ago. Since substantial progress has been made in understanding the basic then, problems involved, although no single universally-accepted theoretical framework has yet emerged. There is a growing number of publications devoted to high-level synthesis, specialized workshops are held regularly, and tutorials on the topic are commonly held at major conferences. This book gives an extensive survey of the research and development in high-level synthesis. In Part I, a short tutorial explains the basic concepts used in high-level synthesis, and follows an example design throughout the synthesis process. In Part II, current high-level synthesis systems are surveyed. …

Taschenbuch. Zustand: Neu. Neuware - The most salient feature of the infor last four chapters of the book evaluate the mation provided by nuclear medicine is its information from an analytical and pathophysiological and functional charac statistical point of view. This approach is ter. For adequate experimental or clinical required for correct decision-making. interpretation, such information should This book is therefore the result of necessarily be interpreted alongside the accumulated experience in nuclear cardiology views of the clinical cardiologist, who is with the invaluable cooperation of medical able to apply it to the individual patient. statisticians. It is directed to physicians This approach, which is routine in every with an interest in nuclear cardiology, to day clinical practice, reaches its plenitude nuclear medicine specialists wishing to when the whole process is completed and learn the uses and limitations of these an intimate cooperation is established procedures in everyday clinical cardiology, between the nuclear medicine specialist and to cardiologists who feel the need to and the clinical cardiologist. In such understand the rationale and methodology instances, each one of these professionals of the studies which benefit their patients. understands the needs, limits and possi We understand that the ultimate reason bilities of the other. for any scientific book is the transmission The present book is the fruit of such of knowledge, and we are fully conscious cooperation. In our hospital, an efficient of the enthusiasm of the authors of the nuclear cardiology team has been made up present text to achieve that aim.…