Springer okt 1989 (6 Ergebnisse)

Buch. Zustand: Neu. Neuware - In breast cancer as in other cancers on the front line of modern interdisciplinary research we have crossed the threshhold of new understanding. Fueled by an awareness that breast cancer is a leading cause of morbidity and mortality in women and honed by rapid technological advances in molecular mechanisms, major inroads into the darkness of this scourge have been accomplished during the past several years. Basic laboratory and clinical research findings must influence and in turn be influenced by efforts to detect, to diagnose and to cure the human disease. It is indeed gratifying to note that the efforts of scientists and clinicians from throughout the world reported in this volume are achieving this objective. The first section of the book focuses on the molecular and genetic basis of breast cancer. The role of specific oncogenes in mammary tumorigenesis using transgenic mice and mammary glands correlating molecular events with specific stages in neoplastic development are described and discussed. Such topics as the nature of specific oncogenes, levels of oncogene expression, the alteration of expression of other growth regulatory genes and the state of the cell in which the oncogene is expressed are specifically addressed. This section of the book is rounded out with discussions on the potential of genetic alterations as indicators of prognosis, the characterization of full-length cDNA codes for breast cancer markers and the function of antigens in tuomorigenesis.…

Buch. Zustand: Neu. Neuware - may be related to another basic assumption in economic psychology: that the human capacity to process information from the environment is limited, and that the kind of optimal use of that information postulated in many economic theories is therefore not possible. The research methods used are mainly geared towards empirical research, and there mostly towards survey research and experimentation. Experimentation involves most often simulated behaviour in a laboratory, which allows the experimental manipulation of possible causes of behaviour which would not be possible in real life. Survey research is the most widely used instrument for investigating real-world behaviour, with all its caveats about establishing causal explanations. Several introductory books (e. g. , Fumham & Lewis, 1986; Lea, Tarpy, & Webley, 1987; van Raaij, van Veldhoven, & Wlimeryd, 1988) and articles (e. g. , van Raaij, 1979; Wiswede, 1988) have appeared recently, which try to give an overview of the field of economic psychology, and which, in varying degrees, demonstrate the three foundations of economic psychology just mentioned. Others have concentrated on certain subtopics, such as the psychology of the labour market (e. g. , Baxter, 1988; Pelzmann, 1986).…

Buch. Zustand: Neu. Neuware - Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).…

Buch. Zustand: Neu. Neuware - The idea to produce the current volume was conceived by Jiirgen Mittelstrass and Robert E. Butts in 1978. Idealist philosophers are wrong about one thing: the temporal gap separating idea and reality can be very long indeed - even ten or so years! Problems of timing were joined by personal problems and by the pressure of other professional commitments. Fortunately, James Brown agreed to cooperate in the editing of the volume; the infusion of his usual energy, good judgement and good-natured promptness saved the volume and made its produc tion possible. Despite the delays, the messages of the papers included in the book have not gone stale. An extremely worthwhile exercise in international philosophical cooperation has come to fruition; the German constructivist philosophical position is here represented in papers in English that will make its contemporary importance available to a larger audience. The editors owe thanks to many persons. All involved in the project owe much to the interest and support of Nicholas Rescher, a friend of the undertaking from the time of its inception. My review of the translations was helped immensely by Andrea Purvis' careful copy editing of the typescript. Most of all, however, we owe gratitude and admiration for the tireless efforts on behalf of this enterprise to Jiirgen Mittelstrass.…

Buch. Zustand: Neu. Neuware - The first Stanford MIPS project started as a special graduate course in 1981. That project produced working silicon in 1983 and a prototype for running small programs in early 1984. After that, we declared it a success and decided to move on to the next project-MIPS-X. This book is the final and complete word on MIPS-X. The initial design of MIPS-X was formulated in 1984 beginning in the Spring. At that time, we were unsure that RISe technology was going to have the industrial impact that we felt it should. We also knew of a number of architectural and implementation flaws in the Stanford MIPS machine. We believed that a new processor could achieve a performance level of over 10 times a VAX 11/780, and that a microprocessor of this performance level would convince academic skeptics of the value of the RISe approach. We were concerned that the flaws in the original RISe design might overshadow the core ideas, or that attempts to industrialize the technology would repeat the mistakes of the first generation designs. MIPS-X was targeted to eliminate the flaws in the first generation de signs and to boost the performance level by over a factor of five. …

Buch. Zustand: Neu. Neuware - G. Petursson and Rikke Hoff-J0rgensen The concept of slow viral infections was first put forward in 1954 by Dr. Bjorn Sigurdsson, an Icelandic physician who had been studying some sheep diseases which were introduced into Iceland with the importation of a foreign breed of sheep in 1933. Sigurdsson's main criteria for defining slow infec tions were a very long initial period without clinical signs lasting months or even years following infection and a rather regular protracted, progres sive course, once clinical symptoms had appeared, usually ending in serious disease or death. Sigurdsson included in this list of slow infections maedi -visna, infectious adenomatosis of sheep, scrapie in sheep, Bittner's mam mary carcinoma and Gross' leukemia in mice. All of these diseases, except scrapie, are caused by retroviruses. The characteristics of slow infections as described above are of prac tical importance for epidemiology, diagnosis and control of these diseases. For many years the slow infections remained primarily a veterinary problem, mainly affecting sheep and goats in certain countries. In recent years, how ever, the human immunodeficiency virus (HIV) causing acquired immunodefici ency syndrome (AIDS), has suddenly appeared in many countries of the world and brought the slow infection concept forcefully to the attention of the medical profession. The disease problems and the economic effects of slow infections of sheep and goats are increasingly recognized in various coun tries. For the reasons stated above we feel that this book should be useful for veterinarians and physicians alike.…