Springer nov 1996 (18 Ergebnisse)

Buch. Zustand: Neu. Neuware - The present century has been a disappointing one for comets, but past centuries often featured spectacular, unforgettable comet shows that dominated the night (and even daytime) sky for months: comets that outshone Venus or even the Moon, whose spectacular tails stretched more than halfway across the sky or were weirdly split, and whose apparition was held responsible for everything from wars to unusually good wine vintages. Published to coincide with the first naked-eye appearance of Comet Hale-Bopp, perhaps our own comet of the century, this book is an irresistible guide to comet facts and lore throughout history. Ottewell, G. (illustrator).…

Buch. Zustand: Neu. Neuware - TheNATO AdvancedStudiesInstituteseries'TargetingofDrugs'wasoriginatedin 1981. It is nowamajorinternationalforum,heldeverytwo yearsin CapeSounion,Greece,in whichthepresentandthefutureofthisimportantareaofresearch in drugdeliveryisdiscussed in greatdepth. PreviousASIsoftheseriesdealtwith drugcarriersofnaturalandsynthetic origin,theirinteractionswith thebiologicalmilieu, waysby whichthefunctionofdrugcarriers iscircumvented and,morerecently,with avarietyofapproaches to carrierdesignor modificationthatcontributeto optimalcarrierfunction. Thepresentbookcontainsthe proceedings ofthe8thNATO ASI, 'TargetingofDrugs:Strategies for Oligonucleotideand GeneDelivery in Therapy', held in CapeSounionduring24June-5 July 1995. Asthetitle implies,thebookdealswith avarietyofsystemsin termsoftheirability to transportnucleic acidsto targetareasin vitro andin vivo in waysthateffectivelymodify,supplement, correct, orcurtailthefunctionofgenesin therapy. Weexpressourappreciation to Mrs. ConchaPerringfor herassistance with the organizationoftheASI. TheASI washeldunderthesponsorship ofNATO ScientificAffairs Division andco-sponsored andgenerouslyfinancedby SmithKlineBeechamPharmaceuticals (KingofPrussia). Financialassistance wasalsoprovidedby SandozPharma(Baseland Athens),GeneMedicine (Houston,USA), ChironCorporation(Emeryville,USA), BYK GuldenLombergChemische (Konstanz,Gernlany),HelpSA(Athens,Greece),Avanti Polar Lipids Inc (Birmingham,USA), OxfordMolecular(Oxford,UK), Pfizer(Kent,UK), andAlza Corporation(PaloAlto, USA). GregoryGregoriadis BrendaMcCormack v CONTENTS Gene Therapy for Inherited Genetic Disease: Possibilities and Problems c. Coutelle Gene Delivery and Therapy: The Case for Cystic Fibrosis 15 E. W. F. W. Alton Immune Responses with Direct Gene Transfer: DNA Vaccines and 21 Implications for Gene Therapy H. L. Davis Oligonucleotides: Molecular Versions for Optimal Use in Vivo 31 E. Saison-Behmoaras, A. Van Aerschot, I. Duroux, C. Hendrix, C. Helene, and P. Herdewijn Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells 45 AJ. Kingsman, Y. Bae, J. c. Griffiths, N. Kim, E. E. Ramsdale, G. Romano, Y. Soneoka, P. M. Cannon, and S. M. Kingsman Adenovirus as Vectors for Gene Therapy 53 M. G. Lee Receptor-Mediated Gene Delivery with Synthetic Virus-like Particles 67 E. Wagner, M. Cotten, and K. Zatloukal Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery 79 A. …

Buch. Zustand: Neu. Neuware - Aesthetic Surgery of the Craniofacial Skeleton is a unique atlas presenting specific procedures for aesthetic craniofacial surgery in a comprehensive and easily understandable style. With over 190 fine line drawings specially created for this volume, this book will have multifaceted applications; as an operation manual for the aesthetic craniofacial surgeon, a reference source for the general plastic surgeon, and as an introductory text for residents in craniofacial, reconstructive, oral, head and neck surgery. It includes close to 100 osteotomy methods and imperative information on patient selection, preoperative procedures, complications and implants.…

Buch. Zustand: Neu. Neuware - Protein Structures: The Cooperative Substructure of Protein Molecules; Y. Bai, S.W. Englander. Protein Folding: Approaches to the Determination of More Accurate Crossrelaxation Rates and the Effects of Improved Distance Constraints on Protein Solution Structures; G.C. Hoogstraten, J.L. Markley. Protein Interactions: How Conventional Antigens and Superantigens Interact with the Human MHC Class II Molecule HLADR1; T. Jardetzky. Nucleic Acids and Nucleic Acid-Protein Interactions: Stimulating the Dynamics of the DNA Double Helix in Solution; M. Hirshberg, M. Levitt. Membranes: Applications of Multidimensional Solidstate NMR Spectroscopy to Membrane Proteins; A. Ramamoorthy, et al. Carbohydrate Structure: Conformation, Mobility, and Function of the N-linked Glycan in the Adhesion Domain of Human CD2; G. Wagner, et al. Abstracts from Course: Protein Structures Abstracts: Solution Structure of the ETS-domain from Murine Ets1: A Winged-helix-turn-helix Motif; L.W. Donaldson. Protein Interactions Abstracts: Designing Mutant Hemoglobins; M. Madrid, et al. Nucleic Acids and Nucleic Acid-Protein Interactions Abstracts: A Study on the Dynamics of a DNA Binding Protein; L.M. Horstink, et al. Poster Abstracts. 55 additional articles. Index. …

Buch. Zustand: Neu. Neuware - International concern in scientific, industrial, and governmental communi ties over traces of xenobiotics in foods and in both abiotic and biotic envi ronments has justified the present triumvirate of specialized publications in and this field: comprehensive reviews, rapidly published research papers progress reports, and archival documentations. These three international publications are integrated and scheduled to provide the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamination and toxicology. This series is reserved ex clusively for the diversified literature on 'toxic' chemicals in our food, our feeds, our homes, recreational and working surroundings, our domestic animals, our wildlife and ourselves. Tremendous efforts worldwide have been mobilized to evaluate the nature, presence, magnitude, fate, and toxi cology of the chemicals loosed upon the earth. Among the sequelae of this broad new emphasis is an undeniable need for an articulated set of authoritative publications, where one can find the latest important world literature produced by these emerging areas of science together with docu mentation of pertinent ancillary legislation. Research directors and legislative or administrative advisers do not have the time to scan the escalating number of technical publications that may contain articles important to current responsibility. Rather, these individu als need the background provided by detailed reviews and the assurance that the latest information is made available to them, all with minimal literature searching. …

Buch. Zustand: Neu. Neuware - This Hopkins chronology describes the poet's family and early education, then gives a day-by-day account of what he was doing, reading and writing, and the people he met. Drawing on some material not published before, it illustrates the working life of a priest-poet whose work was not made public until more than thirty years after his death. There are additional sections on the religious and political background of a major Victorian writer whose life was essentially enigmatic and private.…

Buch. Zustand: Neu. Neuware - This book represents a thoroughly comprehensive treatment of computational intelligence from an electrical power system engineer's perspective. Thorough, well-organised and up-to-date, it examines in some detail all the important aspects of this very exciting and rapidly emerging technology, including: expert systems, fuzzy logic, artificial neural networks, genetic algorithms and hybrid systems. Written in a concise and flowing manner, by experts in the area of electrical power systems who have had many years of experience in the application of computational intelligence for solving many complex and onerous power system problems, this book is ideal for professional engineers and postgraduate students entering this exciting field. This book would also provide a good foundation for senior undergraduate students entering into their final year of study.…

Buch. Zustand: Neu. Neuware - Although its concern is jurisprudence, The Tapestry of the Law is intended to offer neither an original theory of or about law nor an account of other people's theories in textbook form. It is, rather, an attempt to approach the subject without following either of these conventions. The reasons are as follows. Those engaged in legal theory are prone to assert that one cannot properly understand the law unless one takes a jurisprudential approach - preferably their own - to it. Equally, those engaged in exposition of the law may counter that legal theory fails to pay adequate attention to actual law. There is at least some truth in these claims. Analyses, courses and textbooks on both sides do often seem to be produced without reference to the other. Yet such isolation is probably more apparent than real. Most, if not all, so-called 'black letter' lawyers do operate on the basis of certain jurisprudential understandings, even if these are not articulated ones. In the frequently quoted words ofF C S Northrop: There are lawyers, judges and even law professors who tell us they have no legal philosophy.…

Buch. Zustand: Neu. Neuware - This book provides a welcome assessment of the wide-ranging impact of Michel Foucault's work upon a number of disciplines within the social sciences and humanities. It offers close textual readings of Foucault's work along with clear overviews of how his work has been taken up in subjects such as history, philosophy and international relations. It also offers original applications of his work to important topics within feminist theory, political theory, the sociology of race, and socio-legal studies.…

Buch. Zustand: Neu. Neuware - Major transport infrastructures are increasingly in the news as both the engineering and financing possibilities come together. However, these projects have also demonstrated the inadequacy of most existing approaches to forecasting their impacts and their overall evaluation. This collection of papers from a conference organised by the Applied Econometric Association represents a state of the art look at issues of forecasting traffic, developing pricing strategies and estimating the impacts in a set of papers by leading authorities from Europe, North America and Japan.…

Buch. Zustand: Neu. Neuware - Perspectives on Time deals with the problem of time from different perspectives such as logic, physics and philosophy. It contains 18 previously unpublished papers, written by philosophers from various European countries, as well as a large introduction about the history and the main situation in the respective fields today. The prominent issues which are addressed in this book concern the direction of time, the reality of tenses, the objectivity of becoming, the existence in time, and the logical structures of reasoning about time. The papers have been written based on different approaches, partly depending on whether the authors subscribe to an A-theory or a B-theory of time. Audience: Due to the broad variety of approaches the book contains important contributions both for philosophers, philosophers of science, logicians and for scientists working in the field of language and AI.…

Buch. Zustand: Neu. Neuware - The theory of blood circulation is the oldest and most advanced branch of biomechanics, with roots extending back to Huangti and Aristotle, and with contributions from Galileo, Santori, Descartes, Borelli, Harvey, Euler, Hales, Poiseuille, Helmholtz, and many others. It represents a major part of humanity's concept of itself. This book presents selected topics of this great body of ideas from a historical perspective, binding important experiments together with mathematical threads. The objectives and scope of this book remain the same as in the first edition: to present a treatment of circulatory biomechanics from the stand points of engineering, physiology, and medical science, and to develop the subject through a sequence of problems and examples. The name is changed from Biodynamics: Circulation to Biomechanics: Circulation to unify the book with its sister volumes, Biomechanics: Mechanical Properties of Living Tissues, and Biomechanics: Motion, Flow, Stress, and Growth. The major changes made in the new edition are the following: When the first edition went to press in 1984, the question of residual stress in the heart was raised for the first time, and the lung was the only organ analyzed on the basis of solid morphologic data and constitutive equations. The detailed analysis of blood flow in the lung had been done, but the physiological validation experiments had not yet been completed.…

Buch. Zustand: Neu. Neuware - Since the first edition of this book was published in 1987, there have been several important changes in the state of numerical field computation, as discussed in the Introduction. These changes have motivated the publication of this second edition. As with the first edition, the objective of this second edition is to give the newcomer to field computation the information needed to perform practical field computations. Again, clarity of presentation is given greater emphasis than a high degree of sophistication or the state of the art. And again, the basic concepts of field computation are presented as well as the commonly used algorithms. Several persons have provided much valuable information for this second edition. I wish to thank Professor Giorgio Molinari of the University of Genoa, Italy for advice regarding adaptive mesh generation; Dr. C. R. E. Emson of Vector Fields, Ltd., England and Dr. John Brauer of McNeal-Schwendler Corp. for their advice on transient eddy current computation; and Dr. Zoltan Cendes of Ansoft Corp. for information about their adaptive mesh generator. Again, I would like to acknowledge the support for this second edition by my wife, Candace. Again, I could not have written this book without her support.…

Buch. Zustand: Neu. Neuware - Role of Atmospheric Models in Air Pollution Policy and Abatement Strategies: Multipollutant Modeling and Policy: Dressing the Emperor and Avoiding False Paradigms; R.L. Dennis. Meteorological Aspects of Ozone Episodes in Southern Ontario: A Mesoscale Model Investigation; R.S. Tangirala. Integrated Regional Modeling: Meteorological Modeling in Sydney, Australia: Case Study of Smog Event; P.J. Hurley, et al. Lake Breezes and Their Impact on Groundlevel Ozone Transport over Southwestern Ontario and Southeastern Michigan; D.M.L. Sills, P.A. Taylor. Global and Longrange Transport: Sulfur Deposition in Asia: An Assessment of the Present Situation and Future Scenarios; G.R. Carmichael, R.L. Arndt. The European Long Range Tracer Experiment (ETEX): Preliminary Evaluation of Model Intercomparison Exercise; G. Archer, et al. New Developments: Mesoscale Modeling of Clouds and Aerosol Particles; A.I. Flossmann. Accidental Releases: Validation of a Combination of Two Models for Longrange Tracer Simulations; J. Brandt, et al. Model Assessment and Verification: Air Pollution in Coastal Cities; D.G. Steyn. Poster Session: Use of the UB/NMC Model for the Simulation of the Lifecycle of Chernobyl Radioactive Cloud; M. Dacic, B. Telenta. 74 additional articles. Index.…

Buch. Zustand: Neu. Neuware - The book examines all aspects of constructing and using SQUID magnetic sensors that operate at either liquid helium or liquid nitrogen temperatures (4 or 77 K, respectively). There is comprehensive coverage of a range of established and emerging applications: biomagnetism, geophysics, nondestructive evaluation, detection of unexploded ordnance, and gravity gradiometry. The principles of both dc and rf SQUIDS are discussed extensively, as are the geometries, electronic circuitry and analysis techniques required to maximise performance. A major chapter of SQUID gradiometers in real environments presents original information on how to minimise noise from external sources. The discussions of biomagnetism describe the growing importance of neuromagnetometry with systems employing over 100 SQUID sensors, as well as the emergence of magnetocardiography and foetal heartbeat monitoring. Analysis techniques relevant to both biomagnetism and nondestructive evaluation are presented in depth. Audience: Students and professionals engaged in the applications covered and/or in the scientific and engineering aspects of SQUID sensors. …

Buch. Zustand: Neu. Neuware - This volume documents the scientific events of the NATO Advanced Research Workshop (ARW) on The Preparation of Nanoparticles in Solutions and in Solids. The ARW was held in the second largest city in Hungary, Szeged, truthfully referred to as 'the city of sunshine', from March 8 to March 13, 1996. The seventy-seven participants, including seventeen students, came from twentyone different countries. Housing all participants together and arranging a number of social activities fostered lively discussions both inside and outside of formal sessions. Twenty-one key lectures were presented in five sessions. Each session was followed by a fortyfive minutes of general discussion. One evening was devoted to the presentation of fifty-five posters. Thirty-two contribution were submitted and accepted for publication in the present volume. The volume also contains the minutes of the discussions, and a summary of the conclusions of the working groups. The ARW was organized under the auspices and financial support of NATO, City of Szeged, European Research Office of the US Army, Hungarian Academy of Sciences, Hungarian National Committee for Technological Development (OMBF), International Association of Colloid and Interface Scientists IACIS, and National Science Foundation (NSF). Both the organizers and participants gratefully acknowledge the generous support of the agencies. The Editors also thank the high quality and creative contributions of the participants. It is they who made this volume a reality. Janos H. fendler Irnre Dekany ix Glossary of Some Names and Acronyms Advanced Materials Man-made materials having superior mechanical, thennal, electrical, optical, and other desirable properties. …

Buch. Zustand: Neu. Neuware - Triticale's days as a scientific curiosity are definitely over. Its wide acceptance as a feed, grain or forage crop, or for baking and malting, plus its high yields under marginal or stress conditions have made it an economically important crop in countries such as Poland, Germany, Australia, Portugal, Brazil, Morocco and China. This publication contains selected, reviewed, and up-to-date papers presented at the Third International Triticale Symposium held in Lisbon, Portugal, by the International Triticale Association and EUCARPIA. Among the broad spectrum of subjects addressed in these presentations are cytogenetics, biotechnology, genetic resources, breeding, agronomic practices and diseases. Also included are triticale's food, feed and forage uses, as well as its marketing processes. In a world of increasing population and decreasing agricultural resources, triticale offers a genuine solution for increasing land utilization and grain production.…

Buch. Zustand: Neu. Neuware - The preceding volume appeared in 1987 and covered the literature up to the end of 1984. The present work extends the coverage to the end of 1994 with a sprinkling of references to 1995 papers. Nearly 900 new qui nones are described, including one or two which were overlooked previously, together with new work on older compounds. For each new quinone information is provided on the distribution, spectra, structure and chemistry, and on biosynthesis where available. Sadly, there is very little new chemistry, as structures are now elucidated almost entirely by spectroscopic methods and X-ray analysis. As always I am grateful to many colleagues who sent me papers and other information in advance of publication. 1972 and 1987 volumes are referred to as NOQ II and NOQ III, The respectively. In the spectroscopic data the notation ( ) indicates that informa tion is missing or is dubious. R.H.T. Aberdeen, November 1995 1 Benzoquinones 1 New sources of p-benzoquinone are the cephalic glands of Eucera bees and 2 Arthrobacter bacteria and it is part ofthe defensive secretion ofthe caterpillar 3 Romalea guttata. However, the natural occurrence of o-benzoquinone has not been reported and is unlikely. Simple monosubstituted o-benzoquinones occur 4 only as transient metabolic intermediates. It has been shown that in the leaves of X anthium occidentale (Compositae) chlorogenic acid is in equilibrium with a small amount of the corresponding o-quinone but the latter has not been isolated.…