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Buch. Zustand: Neu. Neuware -This volume describes numerous applications of sponge-matrix histoculture to study cancer biology and the treatment of cancer, stem cells, organoids, growth and repair of nerves, lymphoid tissues that produce antibodies, and HIV infection. The chapters in this book cover topics including, in vivo-like growth patterns of multiple types of tumors in Gelfoam® histoculture; development of the histoculture drug response assay (HDRA) for cancer patients; hair-shaft growth in Gelfoam® histoculture of skin as well as isolated hair follicles in Gelfoam® histoculture; the use of Gelfoam® histoculture to discover novel treatment of HIV infection; and imaging DNA repair after UV irradiation damage of cancer cells in Gelfoam® histoculture. The volume explains what is true 3D cell and tissue culture and corrects widespread misconceptions of 3D culture in the literature. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting¿edge and authoritative,3D Sponge-Matrix Histoculture: Methods and Protocolsis a valuable resource that contributes to new cell and tissue culture research, and other diseases based on the true 3D culture.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 252 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores protocols for identifying mutant mice and characterizing parts of their anatomical, functional, cellular, and molecular phenotypes. The chapters in this book look at anatomical and functional phenotyping using quantitative imaging, isolation of specific embryonic cell types for cell culture, analysis of gene expression, and how to define chromatin structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, Mouse Embryogenesis: Methods and Protocols is a valuable resource for experimentalists interested in discovering new aspects of embryogenesis control, organ function, and the origin of disease.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 208 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book serves as an up-to-date Rorschach primer and elaborates on the various applications of Rorschach assessment for adolescents with respect to differential diagnosis, forensic consultation, and therapeutic assessment. It opens with three chapters that provide readers with a basic overview and introduction to the topics integrated throughout the text. The first reviews the development and foundations of the Rorschach Inkblot Method; the second discusses key issues in the assessment of adolescents, with particular attention to differentiating patterns of psychopathology from normal developmental variations; and the third presents general considerations in using performance-based assessment instruments in the assessment of personality functioning in adolescence. Later chapters explore the current status of the Rorschach Inkblot Method with respect to theoretical formulations, research findings, and practice guidelines. The final chapter draws on information in the preceding chapters to present a model for Rorschach assessment of adolescents. This model is designed to facilitate accurate and useful formulations of personality functioning that contribute substantially to advancing responsible adolescent development.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 264 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides a concise, yet comprehensive, state-of-the art overview of GI endoscopic emergencies. Although the emphasis is on endoscopic management, peri-procedural considerations, adjunctive medical therapy, and clinical approaches to commonly encountered GI emergencies are discussed in detail. This sets the stage for the in-depth review of current as well as innovative devices and techniques for endotherapy in GI emergencies. Technical aspects of endoscopic procedures are emphasized and supplemented by online video clips to enhance the educational experience.Written by experts in the field, GI Endoscopic Emergencies serves as a valuable resource for practitioners who deal with GI emergencies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -The international conference entitled 'New Trends in Approximation Theory' was held at the Fields Institute, in Toronto, from July 25 until July 29, 2016. The conference was fondly dedicated to the memory of our unique friend and colleague, André Boivin, who gave tireless service in Canada until his very last moment of his life in October 2014. The impact of his warm personality and his fine work on Complex Approximation Theory was reflected by the mathematical excellence and the wide research range of the 37 participants. In total there were 27 talks, delivered by well-established mathematicians and young researchers. In particular, 19 invited lectures were delivered by leading experts of the field, from 8 different countries.The wide variety of presentations composed a mosaic of aspects of approximation theory, highlighting interesting connections with important contemporary areas of Analysis. Primary topics discussed include application of approximation theory (isoperimetric inequalities, construction of entire order-isomorphisms, dynamical sampling); approximation by harmonic and holomorphic functions (especially uniform and tangential approximation), polynomial and rational approximation; zeros of approximants and zero-free approximation; tools used in approximation theory; approximation on complex manifolds, in product domains, and in function spaces; and boundary behaviour and universality properties of Taylor and Dirichlet series.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Thisbook offers eleven coordinated reviews on multi-scalestructure formation in cosmic plasmas in the Universe. Observations and theories of plasma structures are presentedin all relevant astrophysical contexts, from the Earth¿s magnetosphere through heliospheric and galactic scales to clusters of galaxies and the large scalestructure of the Universe. Basic processes in cosmic plasmas starting fromelectric currents and the helicity conceptgoverning the dynamics of magnetic structures in planet magnetospheresstellar winds, and relativistic plasma outflows like pulsar wind nebulae andActive Galactic Nuclei jets are covered.Themulti-wavelength view from the radio to gamma-rays with modern high resolutiontelescopes discussed in the book reveals a beautiful and highly informativepicture of both coherent and chaotic plasma structures tightly connected bystrong mutual influence. The authors are all leading scientists in theirfields, making this book an authoritative, up¿tödate and enduring contributionto astrophysics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The aim of this book is to improve pyrosequencing protocols as well as instrumentation for better clinical use by describing improvements and novel applications of pyrosequencing technology. Divided into five parts, the book¿s thirty chapters explore advances in pyrosequencing template preparation, pyrosequencing technology innovations, multiplex pyrosequencing based on barcodes, the miniaturization of pyrosequencing equipment, as well as various applications. As part of the Springer Protocols program, chapters contain the kind of detail and practical implementation advice to guarantee successful results in the lab.Comprehensive and thorough, Advances and Clinical Practice in Pyrosequencing serves as a valuable reference for researchers who are engaged in personalized medicine, disease control, and DNA diagnosis in numerous other fields.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Buch. Zustand: Neu. Neuware -This vital collection provides a unique set of techniques to explore the clinical, pathological, and research aspects of the management of patients with esophageal adenocarcinoma. Beginning with an introduction to the basic features of esophageal adenocarcinoma, the book continues with clinical protocols for the management of the cancer, pathological methods for management of the patients and research, as well as protocols for molecular research, which could aid researchers in furthering our understanding of pathogenesis as well as in identifying new targets for the treatment and prevention of adenocarcinoma. Written for the highly successful Methods in Molecular Biology series, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume seeks to understand how organisms and gene functions are influenced by environmental cues while accounting for variation that takes place within and among environmental populations and communities. Microbial Environmental Genomics (MEG) guides readers through methods to analyse the diversity of different organism types (archaea, bacteria, fungi, protists and microfauna), interactions between fungi and trees, and methods to identify and characterize functions and functional diversity of both pro- and eukaryotes. Written for theMethods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Microbial Environmental Genomics (MEG) will serve as a primary research reference for researchers and research managers in environmental microbiology working in the expanding field of molecular ecology and environmental genomics.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 336 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume presents current adaptations of the patch-clamp technique to neuroscience. Chapters focus on in-vivo recordings, voltage-gated channel recording and analysis, dendritic and axonal recordings, synaptic current recording and analysis, advanced fluorescent techniques, optogenetics and voltage-sensitive dye imaging, and finally channel and neuronal modeling. Written for the popular Neuromethodsseries, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical,AdvancedPatch-Clamp Analysis for Neuroscientistsaimsto ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 364 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the use of viral metagenomics to diagnose known viruses for plant and food production, human and animal health, and identifying viral vectors like insects. The chapters in this book cover topics, such as sRNAs isolation from tissues of grapevines and woody plants, high-resolution screening of arthropod and plant viral communities, identifying new pathogens in fish, detecting viruses in mycorrhizal fungi and their orchid host, and insect virus discovery through metagenomic and cell culture-based approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and comprehensive, Viral Metagenomics: Methods and Protocols is a valuable resource for researchers and specialists who are interested in learning more about this evolving field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 232 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume covers various assays and techniques that have been developed to study and characterize the cell migration in vitro, ex vivo, and in vivo. The chapters in this book present readers with the latest protocols to observe, quantify, and control cell migration. Some of the topics explored in this book are: migration in confined environments, microfluidic devices, optogenetics, chemotaxis, electrotaxis, detection of migrasomes, migration of Q cells in Caenorhabditis elegans, of Drosophila macrophages, optogenetics of cell migration, intravital imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting edge and comprehensive, Cell Migration: Methods and Protocols is a valuable resource for anyone interested in learning more about this expanding field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 688 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume details methods and techniques for identification of drug targets, binding sites prediction, high-throughput virtual screening,and prediction of pharmacokinetic properties using computer based methodologies. Chapters guide readers through techniques of the available computational tools, developing prediction models for drug target prediction and de novo design of ligands, structure based drug designing, fragment-based drug designing, molecular docking, and scoring functions for assessing protein-ligand docking protocols. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge,Computational Drug Discovery and Designaims to provide protocols for the use of bioinformatics tools in drug discovery and design.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 500 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 496 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 496 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation).Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level.This book also:Provides a comprehensive view of tissue modeling across multiple systemsBroadens readers¿ understanding of state-of-the-art computational modeling and optical measurements of tissue/cells structuresDescribes in detail fiber scale properties such as orientation and crimpSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 360 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the latest developments in the study of the mechanisms, diagnostics, screening methods, and therapeutics of colorectal cancer. The book¿s chapters are divided into three parts: the chapters in Part One examine techniques used to study the molecular mechanisms in colorectal cancer development and progression. Part Two focuses on the innovative tools used to diagnose and detect cancer lesions in the early stages of cancer. Finally, Part Three discusses recent advancements in treating colorectal tumors and identifying new therapeutic molecules for treatment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Colorectal Cancer: Methods and Protocols is a valuable resource for any scientist and researcher interested in this field of study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 368 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume provides diverse elegant methods, complemented with existing protocols, which are optimized for the current needs in plant root biology as well as for use in plant species other than Arabidopsis thaliana. The collection covers methods ranging from genetic screens, phenotypic analysis, and cell biology methods to systems biology tools and genome-wide approaches. The collection contains a range of complexity from fundamental methods for quantification of different root developmental processes to complex methods that require sophisticated equipment. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 340 pp. Englisch.

Buch. Zustand: Neu. Neuware -The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book is a collection of papers presented at the 9th International Conference of Military Geoscience that was held in 2011. The conference included discussion on a diverse range of geosciences, including military history, military geology, teaching geology from a military prospective, geological influence on the battlefield, and environmental and cultural issues related to management of military lands. Geology and geography have played a significant role in military history, from providing the stone for primitive tools and weapons, to the utilization of terrain in offensive and defensive strategies. Specific to this volume, deserts comprise nearly a third of the Earth¿s surface and have been the site of numerous battles where the dust, heat, and a lack of food and water have provided challenges to military leaders and warriors. This book examines the role of deserts in past and modern warfare, the problems and challenges in managing military lands in desert regions, and how desertenvironmental conditions can impact military equipment and personnel.This proceedings volume should be of interest to scholars, professionals, and those interested in military history, warfare, geology, geography, cultural resources, general science, and military operations.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This is the third edition of a well-known classic on ultrafast nonlinear and linear processes responsible for supercontinuum generation. Part I of the book reviews the progress achieved in experimental and theoretical understanding of the field, and goes over the applications developed since the discovery of the supercontinuum effect. The second part of the book covers recent research activity on supercontinuum phenomena and advances achieved since the publication of the previous edition. The new chapters specifically focus on: normal dispersion photonic band gap fibers; coherence in the supercontinuum; supercontinuum in the UV, NIR, and IR; and supercontinuum in XUV and X-rays for attosecond pulses.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 456 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume introduces the reader to the latest experimental and bioinformatics methods for DNA sequencing, RNA sequencing, cell-free tumour DNA sequencing, single cell sequencing, single-cell proteomics and metabolomics. Chapters detail advanced analysis methods, such as Genome-Wide Association Studies (GWAS), machine learning, reconstruction and analysis of gene regulatory networks and differential coexpression network analysis, and gave a practical guide for how to choose and use the right algorithm or software to handle specific high throughput data or multi-omics data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Computational Systems Biology: Methods and Protocols aims to ensuresuccessful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 432 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -High pressure processing technology has been adopted worldwide at the industrial level to preserve a wide variety of food products without using heat or chemical preservatives. High Pressure Processing: Technology Principles and Applications will review the basic technology principles and process parameters that govern microbial safety and product quality, an essential requirement for industrial application. This book will be of interest to scientists in the food industry, in particular to those involved in the processing of products such as meat, fish, fruits, and vegetables. The book will be equally important to food microbiologists and processing specialists in both the government and food industry. Moreover, it will be a valuable reference for authorities involved in the import and export of high pressure treated food products. Finally, this update on the science and technology of high pressure processing will be helpful to all academic, industrial, local, and state educators in their educational efforts, as well as a great resource for graduate students interested in learning about state-of-the-art technology in food engineering.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 784 pp. Englisch.