springer new york springer us mär 2006 (8 Ergebnisse)

Buch. Zustand: Neu. Neuware -Paleolithic archaeologists and human paleontologists have failed to address the origins of a phenomenon that is both absolutely central to the human way of life and unique to our species.In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and only among humans, some of these codes are created socially, through interactions among individuals. Human culture is thus an emergent phenomenon, one that cannot be understood without taking into account the interactions among individuals. Other species may learn codes socially, from their parents or other members of their species, but the codes are not created socially.Because human society creates the culture that governs individual behavior, it can control individual members in a way that other primate societies cannot. Culture can facilitate cooperative and group activities, but can also lead individuals to behave contrary to their own evolutionary best interests.This book describes the emergent nature of human culture. It proposes hypotheses to explain how a phenomenon that is potentially maladaptive for individuals could have evolved, and to explain why culture plays such a pervasive role in human life. It then reviews the primatological, fossil, and archaeological data to test these hypotheses.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Zustand: Neu. Neuware -As adoption of Electronic Health Record Systems (EHR-Ss) shifts from early adopters to mainstream, an increasingly large group of decision makers must assess what they want from EHR-Ss and how to go about making their choices. The purpose of this book is to inform that decision. This book explains typical needs of a variety of stakeholders, describes current and imminent technologies, and assesses the available evidence regarding issues in implementing and using EHR-Ss.Divided into four important sections--Needs, Current State, Technology, and Going Forward--the book provides the background and general notions regarding the EHRS and lays out the framework; delves into the historical review; presents a high-level view of EHR systems, focused on the needs of different stakeholders in the health care and the health enterprise; offers practical views of existing systems and current (and short-term future) issues in specifying a EHR system and deciding how to approach the institution of such a system; deals with technology issues, from front- to back-end; and describes where we are and where we should be going with EHR systems.Designed for use by chief information officers, chief medical informatics officers, medical liaisons to hospital systems, private practitioners, and business managers at academic and non-academic hospitals, care management organizations, and practices. The book could be used in any medical or health informatics course, at any level (undergrad, fellowship, MBA).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Buch. Zustand: Neu. Neuware -Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.

Buch. Zustand: Neu. Neuware -Preferences and Procedures presents and tests game-theoretic models of European Union legislative decision-making. It is inspired by the idea of linking statistical testing strategies firmly to formal models of EU policymaking. After describing salient features of the EU legislative process and comparing different models of how the EU negotiates new legislative measures, the models' predictive power is evaluated. On a more general level, Preferences and Procedures answers questions regarding the empirically recognizable effects of institutional arrangements on joint bargaining outcomes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 112 pp. Englisch.

Buch. Zustand: Neu. Neuware -Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.

Buch. Zustand: Neu. Neuware -Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -Twenty- ve years have passed since the publication of the Russian version of the book Estimation of Dependencies Based on Empirical Data (EDBED for short). Twen- ve years is a long period of time. During these years many things have happened. Looking back, one can see how rapidly life and technology have changed, and how slow and dif cult it is to change the theoretical foundation of the technology and its philosophy. I pursued two goals writing this Afterword: to update the technical results presented in EDBED (the easy goal) and to describe a general picture of how the new ideas developed over these years (a much more dif cult goal). The picture which I would like to present is a very personal (and therefore very biased) account of the development of one particular branch of science, Empirical - ference Science. Such accounts usually are not included in the content of technical publications. I have followed this rule in all of my previous books. But this time I would like to violate it for the following reasons. First of all, for me EDBED is the important milestone in the development of empirical inference theory and I would like to explain why. S- ond, during these years, there were a lot of discussions between supporters of the new 1 paradigm (now it is called the VC theory ) and the old one (classical statistics).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 528 pp. Englisch.

Buch. Zustand: Neu. Neuware -N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals found in the brain of humans and animals, and yet the functions served by this brain-specific metabolite remain elusive, and controversial. Despite the uncertainties surrounding the functions of NAA in the development and operation of the nervous system, this molecule has attracted the attention of researchers and clinicians for two distinct reasons.First, the acetyl proton on NAA gives off a very prominent signal in water-suppressed, proton magnetic resonance spectroscopy (MRS), which permits clinicians to monitor levels of NAA in the brains of patients in a non-invasive manner. Because NAA is found primarily in neurons, and because the levels in the brain have been found to change rapidly after injury, or slowly during neurodegenerative diseases, MRS has become a preferred method of analyzing nerve cell dysfunction and death without surgical intervention.The second reason that NAA has attracted attention in recent years is that a congenital genetic disorder of NAA metabolism has been found to be the cause of the neurodegenerative disorder known as Canavan¿s disease. Canavan¿s disease is an inherited leukodystrophy that involves myelination pathologies of cortical white matter, leading to death within 10 years of birth. The genetic mutation results in a defective enzyme that de-acetylates NAA in the brain, resulting in a significant rise in NAA levels in the brain and urine. This enzyme, known as aspartoacylase (ASPA), appears to be involved in the process of myelination, such that a defective enzyme results in a disruption of the myelination of nerve fibers during development.The purpose of this symposium is to bring together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronaldevelopment and functioning. It is hoped that bringing researchers and clinicians together in such a forum will facilitate rapid progress in this emerging field, and will help lead to discoveries that can alleviate the suffering caused by a deadly, inheritable infantile disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 400 pp. Englisch.