springer new york springer us mär 2004 (8 Ergebnisse)

Buch. Zustand: Neu. Neuware -Just over ten years ago when the first drafts of this book were being written, and even more so a few years after that as it was making its way through the publication process, alpine skiing was experiencing what eventually became a complete revolution in equipment and tech nique: 'shaped' or 'parabolic' skis completely took over the market, and even relatively beginning skiers expected to carve graceful turns as they schussed down the slopes. Re-reading our work with an eye to revision, we have been surprised to see how our focus on the physics of skiing in the first edition al lowed us to recognize the fundamental importance of what were then quite novel changes in equipment and technique. The essence of the enhancement offered by shaped skis is their greater sidecut radius. Our original discussion (then and now in Chapters 3 and 4) of the crucial role that a ski's sidecut plays in carving a turn caused us to write, for the most part, as if the shaped ski had always been in existence. Sim ilarly, our interest in the geometry ofthe sidecut allowed us to discuss snowboards in some detail as well, for the key to their ability to 'shred' down the mountain is their deep sidecut.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Buch. Zustand: Neu. Neuware -This text is an elementary introduction to differential geometry. Although it was written for a graduate-level audience, the only requisite is a solid back ground in calculus, linear algebra, and basic point-set topology. The first chapter covers the fundamentals of differentiable manifolds that are the bread and butter of differential geometry. All the usual topics are cov ered, culminating in Stokes' theorem together with some applications. The stu dents' first contact with the subject can be overwhelming because of the wealth of abstract definitions involved, so examples have been stressed throughout. One concept, for instance, that students often find confusing is the definition of tangent vectors. They are first told that these are derivations on certain equiv alence classes of functions, but later that the tangent space of ffi.n is 'the same' n as ffi. . We have tried to keep these spaces separate and to carefully explain how a vector space E is canonically isomorphic to its tangent space at a point. This subtle distinction becomes essential when later discussing the vertical bundle of a given vector bundle.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Buch. Zustand: Neu. Neuware -Design and Analysis of High Efficiency Line Drivers for xDSL covers the most important building block of an xDSL (ADSL, VDSL, .) system: the line driver. Traditional Class AB line drivers consume more than 70% of the total power budget of state-of-the-art ADSL modems. This book describes the main difficulties in designing line drivers for xDSL. The most important specifications are elaborated staring from the main properties of the channel and the signal properties. The traditional (class AB), state-of-the-art (class G) and future technologies (class K) are discussed.The main part of Design and Analysis of High Efficiency Line Drivers for xDSL describes the design of a novel architecture: the Self-Oscillating Power Amplifier or SOPA.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Buch. Zustand: Neu. Neuware -Testing Static Random Access Memories covers testing of one of the important semiconductor memories types; it addresses testing of static random access memories (SRAMs), both single-port and multi-port. It contributes to the technical acknowledge needed by those involved in memory testing, engineers and researchers. The book begins with outlining the most popular SRAMs architectures. Then, the description of realistic fault models, based on defect injection and SPICE simulation, are introduced. Thereafter, high quality and low cost test patterns, as well as test strategies for single-port, two-port and any p-port SRAMs are presented, together with some preliminary test results showing the importance of the new tests in reducing DPM level. The impact of the port restrictions (e.g., read-only ports) on the fault models, tests, and test strategies is also discussed.Features:Fault primitive based analysis of memory faultsA complete framework of and classification memory faultsA systematic way to develop optimal and high quality memory test algorithmsA systematic way to develop test patterns for any multi-port SRAMChallenges and trends in embedded memory testing.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -It is now over one hundred years since von Behring and Kitsato first concluded experiments that led to the use of passive immunisation, employing antibodies raised in animals against tetanus and diphtheria toxins. The advancement of technology both in manufacturing purity product in a cost effective way and the clinical research has proved that antibodies are one ofthe most successful products in biotechnology. Monoclonal antibodies account for between one-third and one-halfof all pharmaceutical products in development and human clinical trials. Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year. It is widely acknowledged that there is currently a worldwide shortage of biomanufacturing capacity, and the active pharmaceutical ingredient material requirements for these products are expected to increase. Thus the industry is looking for new sources and extensive studies are being carried out not only for alternative technology to meet the needs but also to reveal the new therapeutic applicationsofantibodies. This book brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. The first four chapters give an overview of the new technologies and the successful application in the manufacture of monoclonal antibodies with clinical purity. The next chapters address the application of antibodies in cancer therapy and functional genomic therapy.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book is an attempt to present a unified theory of rare event simulation and the variance reduction technique known as importance sampling from the point of view of the probabilistic theory of large deviations. This framework allows us to view a vast assortment of simulation problems from a single unified perspective. It gives a great deal of insight into the fundamental nature of rare event simulation. Unfortunately, this area has a reputation among simulation practitioners of requiring a great deal of technical and probabilistic expertise. In this text, I have tried to keep the mathematical preliminaries to a minimum; the only prerequisite is a single large deviation theorem dealing with sequences of Rd valued random variables. (This theorem and a proof are given in the text.) Large deviation theory is a burgeoning area of probability theory and many of the results in it can be applied to simulation problems. Rather than try to be as complete as possible in the exposition of all possible aspects of the available theory, I have tried to concentrate on demonstrating the methodology and the principal ideas in a fairly simple setting. Madison, Wisconsin 2003 James Antonio Bucklew Contents 1. Random Number Generation . . . . . . . . . . . . . . . . . . . . . 1 . . . . . . . . 1.1 Uniform Generators. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 Nonuniform Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.2.1 The Inversion Method . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.2.2 The Acceptance---Rejection Method . . . . . . . . . . . . 10 . . . . . 1.3 Discrete Distributions . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . 1.3.1 Inversion by Truncation of a ContinuousAnalog. . . . . . 14 1.3.2 Acceptance---Rejection . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . . .Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.

Buch. Zustand: Neu. Neuware -If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:concepts in development of manufacturing strategiesimportance of antibody fragmentsapplication of chromatography method developmentquality controleffect of expression on antibody propertiesvirus removal and safetypharmacokineticsregulatory aspects.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Buch. Zustand: Neu. Neuware -Operational Amplifier Speed and Accuracy Improvement proposes a new methodology for the design of analog integrated circuits. The usefulness of this methodology is demonstrated through the design of an operational amplifier. This methodology consists of the following iterative steps: description of the circuit functionality at a high level of abstraction using signal flow graphs; equivalent transformations and modifications of the graph to the form where all important parameters are controlled by dedicated feedback loops; and implementation of the structure using a library of elementary cells. Operational Amplifier Speed and Accuracy Improvement shows how to choose structures and design circuits which improve an operational amplifier's important parameters such as speed to power ratio, open loop gain, common-mode voltage rejection ratio, and power supply rejection ratio. The same approach is used to design clamps and limiting circuits which improve the performance of the amplifier outside of its linear operating region, such as slew rate enhancement, output short circuit current limitation, and input overload recovery.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.