springer new york springer new york sep 2010 (37 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware -Go-To Telescopes Under Suburban Skies is the first book specifically written for amateur astronomers who own, or who are about to purchase, a computer-controlled ¿go-tö telescope. The advantage of the ¿go-tö capability is enormous ¿ the telescope can be aimed at any object in the sky with great speed and accuracy ¿ which is why these instruments are so popular.Making the realistic assumption that the observer is using a relatively small telescope and is observing from a backyard in a suburban area, this book provides literally hundreds more targets beyond those offered by the built-in ¿nightly tours¿ that feature on the telescope¿s computer tours. And instead of wasting many pages on maps and coordinates, it leads the computer to locate the targets, and so has room to suggest many more fascinating deep-sky objects and provide detailed observing lists and information about what's being viewed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In 1609 Galileo first used his telescope to kick start the science of observational astronomy - an event that proved to be of enormous historic, scientific, and cultural importance. Galileo and 400 Years of Telescopic Astronomy will feature the life and achievements of Galileo, around which has pivoted the story of four centuries of telescopic astronomy. The book will detail how astronomy has progressed through four centuries and contain glimpses of future space research and astronomy goals. Uniquely, interwoven with the text will be a range of practical projects for backyard astronomers in which to participate, projects that serve to illustrate many of Galileo's scientific discoveries.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The square root of 2 is a fascinating number ¿ if a little less famous than such mathematical stars as pi, the number e, the golden ratio, or the square root of ¿1. (Each of these has been honored by at least one recent book.) Here, in an imaginary dialogue between teacher and student, readers will learn why v2 is an important number in its own right, and how, in puzzling out its special qualities, mathematicians gained insights into the illusive nature of irrational numbers. Using no more than basic high school algebra and geometry, David Flannery manages to convey not just why v2 is fascinating and significant, but how the whole enterprise of mathematical thinking can be played out in a dialogue that is imaginative, intriguing, and engaging. Original and informative, The Square Root of 2 is a one-of-a-kind introduction to the pleasure and playful beauty of mathematical thinking.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Comets have inspired wonder, excitement and even fear ever since they were first observed. But they are important members of the solar system, that contain material from early in the life of the system, held in deep-freeze. This makes them key in our understanding of the formation and evolution of many Solar System bodies.Recent ground- and space-based observations have changed much in our understanding of comets. Comets, and How to Observe Them gives a summary of our current knowledge and describes how amateur astronomers can contribute to the body of scientific knowledge of comets. This book contains many practical examples of how to construct comet light-curves, measure how fast a comet¿s coma expands, and determine the rotation period of the nucleus. All these examples are illustrated with drawings and photographs.Because of their unpredictable nature comets are always interesting and sometime spectacular objects to observe and image. The second part of the book therefore takes the reader through the key observing techniques that can be used with commercially available modern observing equipment, from basic observations to more scientific measurements.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Weird Astronomy appeals to all who are interested in unusual celestial phenomena, whether they be amateur or professional astronomers or science buffs who just enjoy reading of odd coincidences, unexplained observations, and reports from space probes that 'don¿t quite fit.' This book relates a variety of 'unusual' astronomical observations ¿ unusual in the sense of refusing to fit easily into accepted thinking, or unusual in the observation having been made under difficult or extreme circumstances. Although some of the topics covered are instances of 'bad astronomy,' most are not. Some of the observations recorded here have actually turned out to be important scientific breakthroughs.Included are some amusing anecdotes (such as the incident involving 'potassium flares' in ordinary stars and the story of Abba 1, the solar system¿s own flare star!), but the book¿s purpose is not to ridicule those who report anomalous observations, nor is it to challenge scientific orthodoxy. It is more to demonstrate how what's 'weird' often turns out to be far more significant than observations of what we expect to see.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Choosing and Using a Refracting Telescope has been written for the many amateur astronomers who already own, or are intending to purchase, a refracting telescope ¿ perhaps to complement their existing arsenal of larger reflecting telescopes ¿ or for the specialist who requires a particular refractor for serious astronomical applications or nature studies.Four hundred year ago, during the winter of 1609, a relatively unknown Italian scientist, Galileo Galilei designed a spyglass with two crude lenses and turned it skyward. Since then, refractors have retained their dominance over all types of reflector in studies of the Moon, planets and double stars because of the precision of their optics and lack of a central obstruction in the optical path, which causes diffraction effects in all commercially-made reflectors.Most mature amateur astronomers got started with a 60mm refractor, or something similar. Thirty years ago, there was little choice available to the hobbyist, but in the last decade long focus crown-flint achromats have moved aside for some exquisitely crafted apochromatic designs offered by leading commercial manufacturers. There has been a huge increase in the popularity of these telescopes in the last few years, led by a significant increase in the number of companies (particularly, William Optics, Orion USA, StellarVue, SkyWatcher and AstroTech) who are now heavily marketing refractors in the amateur astronomical magazines.In Choosing and Using a Refracting Telescope, well-known observer and astronomy writer Neil English celebrates the remarkable history and evolution of the refracting telescope and looks in detail at the instruments, their development and their use.A major feature of this book is the way it compares not only different classes of refractor, but also telescopes of each class that are sold by various commercial manufacturers. The author is perhaps uniquely placed to do this, having used and testedliterally hundreds of different refracting telescopes over three decades.Because it includes many diverse subjects such as imaging with consumer-level digital cameras, imaging with webcams, and imaging with astronomical CCD cameras ¿ that are not covered together in equal depth in any other single volume ¿ Choosing and Using a Refracting Telescope could become the ¿refractor bible¿ for amateur astronomers at all levels, especially those who are interested in imaging astronomical objects of every class.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -The eld of sensory science has grown exponentially since the publication of the p- vious version of this work. Fifteen years ago the journal Food Quality and Preference was fairly new. Now it holds an eminent position as a venue for research on sensory test methods (among many other topics). Hundreds of articles relevant to sensory testing have appeared in that and in other journals such as the Journal of Sensory Studies. Knowledge of the intricate cellular processes in chemoreception, as well as their genetic basis, has undergone nothing less than a revolution, culminating in the award of the Nobel Prize to Buck and Axel in 2004 for their discovery of the olfactory receptor gene super family. Advances in statistical methodology have accelerated as well. Sensometrics meetings are now vigorous and well-attended annual events. Ideas like Thurstonian modeling were not widely embraced 15 years ago, but now seem to be part of the everyday thought process of many sensory scientists. And yet, some things stay the same. Sensory testing will always involve human participants. Humans are tough measuring instruments to work with. They come with varying degrees of acumen, training, experiences, differing genetic equipment, sensory capabilities, and of course, different preferences. Human foibles and their associated error variance will continue to place a limitation on sensory tests and actionable results. Reducing, controlling, partitioning, and explaining error variance are all at the heart of good test methods and practices.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 624 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Fundamentals of Plasma Physics is a general introduction designed to present a comprehensive, logical and unified treatment of the fundamentals of plasma physics based on statistical kinetic theory, with applications to a variety of important plasma phenomena. Its clarity and completeness makes the text suitable for self-learning and for self-paced courses.Throughout the text the emphasis is on clarity, rather than formality, the various derivations are explained in detail and, wherever possible, the physical interpretations are emphasized. The mathematical treatment is set out in great detail, carrying out the steps which are usually left to the reader. The problems form an integral part of the text and most of them were designed in such a way as to provide a guideline, stating intermediate steps with answers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 704 pp. Englisch.

Buch. Zustand: Neu. Neuware -Biomaterials for Clinical Applications is organized according to the World Health Organization¿s report of the top 11 causes of death worldwide, and lays out opportunities for both biomaterials scientists and physicians to tackle each of these leading contributors to mortality. The introductory chapter discusses the global burden of disease. Each of the subsequent eleven chapters focuses on a specific disease process, beginning with the leading cause of death worldwide, cardiovascular disease. The chapters start with describing diseases where clinical needs are most pressing, and then envisions how biomaterials can be designed to address these needs, instead of the more technologically centered approached favored by most books in the field. This book, then, should appeal to chemical engineers and bioengineers who are designing new biomaterials for drug delivery and vaccine delivery, as well as tissue engineering.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient¿s survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and alleviate the disease.Typically, herbal preparations contain single or multiple plant ingredients, including a number of potential active components. Yet, they remain classified as food supplements and thus are exempt from regulations on quality control and proof of efficacy that govern standard pharmaceuticals. Clinical evidence for many preparations is often based on non-documented or anecdotal evidence. In consequence, several preparations with unproven efficacy are circulating in the market with the fear of interference with standard cancer therapies and/or severe toxicity that some can generate, in addition to the unjustified economical burden to patients. Despite inconsistent and conflicting clinical results single molecules have been isolated from herbal preparations and many are exploited to develop potential novel agents.This has fostered the need to organize a set of timely, in-depth and up-to-date review covering the latest developments in alternative cancer management from a scientific and clinical perspective dedicated to the medical community and health care providers, as well as to patients and their families. This book brings the latest comprehensive cancer information and practical recommendations on the best documented practice of alternativetherapies for cancer management put together by recognized experts in the fields of medical oncology, traditional medicine, and cancer pharmacology. It goes hand-in-hand with the patient¿s medical treatment options, quality of life issues, and more. The book is organized into four major sections: The first is an overview of the cancer syndrome by renowned medical oncologists from the USA and Europe. The second is a comprehensive description of traditional medicine by renowned experts from China and Germany. The third is an overview on the pharmacological impact of herb-based formulations on standard chemotherapy agents used in clinical practice. The fourth is a survey of cases reports from several hospitals with approved practice of alternative medicine.The book will feature simple definitions and essential information grouped in both medical and lay-term terminology, and straightforward illustrations related to human physiology, disease definition, scientific data on know and potential mechanisms of action, and preventive approaches.Finally, the book will feature collaboration of experts from China, India, USA, Canada, Germany, France, and other centres with recognized expertise in alternative/traditional medicine. This international cooperation is crucial to cover the complex topic of alternative therapies for cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 744 pp. Englisch.

Buch. Zustand: Neu. Neuware - As the study of Palaeolithic technologies moves towards a more analytical approach, it is necessary to determine a consistent procedural framework. The contributions to this timely and comprehensive volume do just that. This volume incorporates a broad chronological and geographical range of Palaeolithic material from the Lower to Upper Palaeolithic. The focus of this volume is to provide an analysis of Palaeolithic technologies from a quantitative, empirical perspective.As new techniques, particularly quantitative methods, for analyzing Palaeolithic technologies gain popularity, this work provides case studies showcasing these new techniques.Employing diverse case studies, and utilizing multivariate approaches, morphometrics, model-based approaches, phylogenetics, cultural transmission studies, and experimentation, this volume provides insights from international contributors at the forefront of recent methodological advances.

Taschenbuch. Zustand: Neu. Neuware -This volume, which is completely dedicated to continuous bivariate dist- butions, describes in detail their forms, properties, dependence structures, computation, and applications. It is a comprehensive and thorough revision ofanearliereditionof¿ContinuousBivariateDistributions,Emphasizing- plications¿ by T.P. Hutchinson and C.D. Lai, published in 1990 by Rumsby Scienti c Publishing, Adelaide, Australia. It has been nearly two decades since the publication of that book, and much has changed in this area of research during this period. Generali- tions have been considered for many known standard bivariate distributions. Skewed versions of di erent bivariate distributions have been proposed and appliedtomodeldatawithskewnessdepartures.Byspecifyingthetwocon- tional distributions, rather than the simple speci cation of one marginal and one conditional distribution, several general families of conditionally spe- ed bivariate distributions have been derived and studied at great length. Finally, bivariate distributions generated by a variety of copulas and their exibility (in terms of accommodating association/correlation) and str- tural properties have received considerable attention. All these developments andadvancesnecessitatedthepresentvolumeandhavethusresultedinas- stantially di erent version than the last edition, both in terms of coverage and topics of discussion.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 724 pp. Englisch.

Buch. Zustand: Neu. Neuware -The transition to adulthood involves, for most individuals, moving from school to work, establishment of long-term relationships, possibly parenting, and a number of other psychosocial transformations. Now more than ever, there is a concern within popular and research literature about children growing up too soon or too late or failing to realize changes associated with being adult. With this in mind, the book intends to answer a series of timely questions in regard to transition to adulthood and propose a wholly new approach to counseling that enables youth to engage fully in their lives and achieve their best.Active Transition to Adulthood: A New Approach for Counseling will discuss the authors¿ work on the transition to adulthood (including early and late adolescence) from an entirely innovative perspective ¿ action theory. Over a period of 10-15 years the authors have collected substantial data on adolescents and youth in transition, and will present an approach to counseling based on these data and cases. The action theory perspective in which the authors have grounded their work addresses the intentional, goal-directed behavior of persons and groups that is expressed through particular actions, longer-term projects, and life-encompassing careers. In this book, both transition to adulthood and counseling will be covered in the language of goal-directed action. In this way both transition and counseling reflect and capture the action, projects, and careers in which families, youth, and clients are engaged and use to construct on-going identity and other narratives.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Buch. Zustand: Neu. Neuware -Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 364 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The book will synthesize and integrate better what are often disparate ideas, themes, and methods across substantive areas of white-collar crime and criminology and criminal justice.The book also puts together critical and emerging topics within criminology and criminal justice that have important implications for the study of white-collar crime and criminology/criminal justice more generally.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 404 pp. Englisch.

Buch. Zustand: Neu. Neuware -The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Zustand: Neu. Neuware -Current Ornithology publishes authoritative, up-to-date, scholarly reviews of topics selected from the full range of current research in avian biology. Topics cover the spectrum from the molecular level of organization to population biology and community ecology. The series seeks especially to review (1) fields in which an abundant recent literature will benefit from synthesis and organization, or (2) newly emerging fields that are gaining recognition as the result of recent discoveries or shifts in perspective, or (3) fields in which students of vertebrates may benefit from comparisons of birds with other classes. All chapters are invited, and authors are chosen for their leadership in the subjects under review.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Buch. Zustand: Neu. Neuware -Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene¿environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world¿s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 536 pp. Englisch.

Buch. Zustand: Neu. Neuware -Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis ¿ vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

Buch. Zustand: Neu. Neuware -Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers.The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Buch. Zustand: Neu. Neuware -Alladi Ramakrishnan (1923¿2008) was an eminent scientist who had a wide range of research interests in theoretical and mathematical physics. Professor Ramakrishnan made signi cant contributions to probability and statistics, elem- tary particle physics, cosmic rays and astrophysics, matrix theory, and the special theory of relativity. Ramakrishnan believedstrongly that in addition to doing fun- mental research, one must contribute to the advancementof the profession. Inspired by his visit to the Institute for Advanced Study in Princeton in 1957¿1958, he returned to Madras and began the Theoretical Physics Seminar at his family home Ekamra Nivas. These seminars were ultimately responsible for the creation of MATSCIENCE, The Institute of Mathematical Sciences in 1962. This institute, of which he was the Director for its rst 21years, has grown steadily in size and stature, and is his monumental contribution to the profession. In a distinguished scienti c life that has spanned more than ve decades, Professor Ramakrishnan has come into close contact with, and was in uenced by, several eminent mathema- cians and physicists, and has moulded the careers of his several students and young researchers. This volume, which is a tribute to his great legacy, not only deals with his signi cant contributions to research and the profession, but also contains a ne collection of research and survey papers by leading physicists and mathematicians that cover a broad range of areas in the mathematical sciences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 596 pp. Englisch.

Buch. Zustand: Neu. Neuware - In the late 1970s and early 1980s, our nation began to grapple with the legacy of past disposal practices for toxic chemicals. With the passage in 1980 of the Comprehensive Envir- mental Response, Compensation, and Liability Act (CERCLA), commonly known as Sup- fund, it became the law of the land to remediate these sites. The U. S. Department of Defense (DoD), the nation's largest industrial organization, also recognized that it too had a legacy of contaminated sites. Historic operations at Army, Navy, Air Force, and Marine Corps facilities, ranges, manufacturing sites, shipyards, and depots had resulted in widespread contamination of soil, groundwater, and sediment. While Superfund began in 1980 to focus on remediation of heavily contaminated sites largely abandoned or neglected by the private sector, the DoD had already initiated its Installation Restoration Program in the mid-1970s. In 1984, the DoD began the Defense Environmental Restoration Program (DERP) for contaminated site assessment and remediation. Two years later, the U. S. Congress codified the DERP and directed the Secretary of Defense to carry out a concurrent program of research, development, and demonstration of innovative remediation technologies. As chronicled in the 1994 National Research Council report, 'Ranking Hazardous-Waste Sites for Remedial Action,' our early estimates on the cost and suitability of existing techn- ogies for cleaning up contaminated sites were wildly optimistic. Original estimates, in 1980, projected an average Superfund cleanup cost of a mere $3.

Buch. Zustand: Neu. Neuware -Prostate cancer is the most common noncutaneous prostate cancer. Research has revealed several distinct malignancy and the second leading cause of cancer mechanisms of castration-resistant disease that may deaths among men in the United States. It is a critical converge in patients with disease progression on public health problem and remains incurable in the ADT. Many approaches are currently being evaluated metastatic setting with mortality that usually occurs as to improve the treatment of this condition and these a result of castration-resistant disease. fndings have identifed several potential targets for Since Huggins and Hodges¿ report of the dra- therapeutic intervention. These include drugs that are matic clinical effects of suppressing serum testos- more active or less toxic chemotherapy agents; drugs terone levels in men with advanced prostate cancer that induce androgen deprivation; drugs that target in 1941, hormone therapy (also called androgen the androgen receptor and/or androgen synthesis; deprivation therapy [ADT]) has become widely drugs that target specifc pathways, including ang- accepted as the mainstay of therapy for the treat- genesis and tyrosine kinase inhibitors, endothelin ment of advanced prostate cancer. ADT combined antagonists and matrix metalloproteinase inhibitors; with radiation therapy is a standard of care in the and immunologic approaches. Many of these agents treatment of men with locally advanced prostate seem promising and the rationale and effcacy of cancer on the basis of evidence that shows improved these emerging therapies remain to be validated in survival. The role of ADT in the management of future clinical trials.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 448 pp. Englisch.

Buch. Zustand: Neu. Neuware -The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed ¿immune surveillance¿ in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 788 pp. Englisch.

Buch. Zustand: Neu. Neuware -Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ¿drivers¿ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered.This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 556 pp. Englisch.

Buch. Zustand: Neu. Neuware -Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Buch. Zustand: Neu. Neuware -Since the first works introducing the aluminum intercalated clay family in the early 1970s, interest in the synthesis of pillared interlayered clays has increased tremendously, especially research into the properties and applications of new synthesis methods. The need for solids that could be used as cracking catalysts with larger pores than zeolitic materials has spurred the synthesis of new porous materials from clays. Pillared Clays and Related Catalysts reviews the properties and applications of pillared clays and other layered materials used as catalysts, focusing on:the acidity of pillared clays and the effect it has on catalytic performancethe use of pillared clays as supports for catalytically active phases, and the use of the resulting solids in environmentally friendly reactionsthe applications of the selective reduction of NOxthe comparison between the reactions of pillared clays and anionic clays.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 540 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book aims to bring to the forefront a field that has been developing since the late 1990s called the STAR pathway for Signal Transduction and Activation of RNA. It is a signaling pathway that targets RNA directly; in contrast to the canonical signal¿kinase cascade¿transcription factor¿DNA¿RNA. It is proposed to allow quick responses to environment changes such as those necessary in many biological phenomenona such as the nervous system, and during development. The pathway is diagramed in Chapter 1, Figure1. This chapter is a historical introduction and general review with some new data on theoretical miRNAs binding sites and STAR mRNAs. In Chapter 2, Feng and Banks address the accumulating evidence that the RNA-binding activity and the homeostasis of downstream mRNA targets of STAR proteins can be regulated by phosphorylation in response to various extracellular signals. Then Ryder and Massi review the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets. Next Claudio Sette offers an overview of the post-translational modifications of STAR proteins and their effects on biological functions, followed by two chapters dedicated to in depth review of STAR function in spermatogenesis and in mammalian embryonic development. Chapters 7 and 8 discuss what can be learned from STAR proteins in non-mammalian species; in Drosophila and Gld-1 and Asd-2 in C. elegans. Next Rymond discusses the actual mech- ics of splicing with mammalian SF1.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Buch. Zustand: Neu. Neuware -Agriculture is one of the few industries that has been creating resources conti- ously from nature. Sustainability of this industry is a crucial issue at now-a-days. Agricultural technologies are important to feed the growing world population. Agricultural engineering has been applying scienti c principles for the optimal use of natural resources in agricultural production for the bene t of humankind. The role of agricultural engineering is increasing in the coming days at the forthcoming challenges of producing more food with less water coupled with climate uncertainty. I am happy to know that a book entitled 'Fundamentals of Irrigation and On-farm Water Management', written by Engr. Dr. M. H. Ali, is going to be p- lished by Springer. The book is designed to cover the major elds of agricultural and environmental engineering such as weather, plant, soil, water, and basics of on-farm water management. The book will be quite useful for the students of agricultural engineering. Students of other related branches of engineering s- ences, and engineers working in the eld and at research institutes will also be beni ted. The book may serve as a text book for the students and as a practical hand-book for the practitioners and researchers in the eld of irrigation and on-farm water management. Utilization of the recent literature in the area and citation of relevant journals / reports have added a special value to this book. Considering the topics covered, engineers, scientists, practitioners, and educators will nd this book as a valuable resource.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 584 pp. Englisch.