springer new york springer new york jul 2009 (20 Ergebnisse)

Buch. Zustand: Neu. Neuware - Optimization: Structure and Applications presents selected contributions from renowned researchers in the fields of operations research and industrial engineering. The book is divided into two parts; the first focuses on mathematical structure, and the second, on real-world applications. The work includes recent developments in several optimization-related topics such as decision theory, linear programming, turnpike theory, duality theory, convex analysis, and queuing theory. The applications presented include, but are not limited to, data imaging, network capacity allocation, water system management, and materials design.The 21 self-contained chapters in this volume are devoted to the examination of modern trends and open problems in the field of optimization. This book will be a valuable tool not only to specialists interested in the technical detail and various applications presented, but also to researchers interested in building upon the book's theoretical results.

Taschenbuch. Zustand: Neu. Neuware -In 'Paving the Way for Apollo 11' David Harland explains the lure of the Moon to classical philosophers, astronomers, and geologists, and how NASA set out to investigate the Moon in preparation for a manned lunar landing mission. It focuses particularly on the Lunar Orbiter and Surveyor missions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - What do Tetra aquarium supplies, Elector-Nite sensors, and Nissha touch panels have in common They are typical 'hidden champions,' medium-sized, unknown companies (with annual revenues under $4 billion) that have quietly, under the radar, become world market leaders in their respective industries. Hermann Simon has been studying these hidden champions for over 20 years, and in this sequel to his worldwide bestseller, Hidden Champions, he explores the dramatic impact of globalization on these companies and their outstanding international success. Going deep inside more than a thousand hidden champions around the world, Simon reveals the common patterns, behaviors, and approaches that make these companies successful, and, in many cases, able to sustain world market leadership for generations, despite intense competition, financial pressures, and constantly evolving market dynamics. In the tradition of In Search of Excellence, Built to Last, and Good to Great, Simon identifies the factors in business operations, customer service and marketing, innovation, human resources management, organizational design, leadership, and strategy that separate these outstanding performers from the rest of the pack - and from the large corporations of the day. In the process, he provides a glimpse behind the curtains of many secretive companies who buck today's management fads, and succeed instead through such common-sense strategies as focusing on core capabilities, delivering real value to the customer, establishing long-term relationships, innovating continuously, rewarding employees for performance, decentralized operations, and developing an unparalleled global presence. Hidden champions teach us that good management means doing many small things better than the competition-quietly, with determination, commitment, and never-ending stamina. And in turbulent economic times, the hidden champions represent an antidote to the short-sightedand excessive practices that have brought many corporate giants crashing down. The hidden champions provide invaluable lessons for all stakeholders in the business community, from entrepreneurs to corporate managers, investors to employees, union organizers to regulators, advanced and emerging countries and may well serve as the new role models for sustainable economic growth in the globalized world of the future.

Taschenbuch. Zustand: Neu. Neuware -Mars Outpost provides a detailed insight into the various technologies, mission architectures, medical requirements, and training needed to send humans to Mars. It focuses on mission objectives and benefits, and the risks and complexities that are compounded when linked to an overall planet exploration program involving several expeditions and setting up a permanent presence on the surface.The first section provides the background to sending a human mission to Mars. Analogies are made with early polar exploration and the expeditions of Shackleton, Amundsen, and Mawson. The interplanetary plans of the European Space Agency, NASA, and Russia are examined, including the possibility of one or more nations joining forces to send humans to Mars. Current mission architectures, such as NASA¿s Constellation, ESA¿s Aurora, and Ross Tierney¿s DIRECT, are described and evaluated.The next section looks at how humans will get to the Red Planet, beginning with the preparation of the crew. The author examines the various analogues to understand the problems Mars-bound astronauts will face. Additional chapters describe the transportation hardware necessary to launch 4-6 astronauts on an interplanetary trajectory to Mars, including the cutting edge engineering and design of life support systems required to protect crews for more than a year from the lethal radiation encountered in deep space. NASA¿s current plan is to use standard chemical propulsion technology, but eventually Mars crews will take advantage of advanced propulsion concepts, such as the Variable Specific Impulse Magnetoplasma Rocket, ion drives and nuclear propulsion.The interplanetary options for reaching Mars, as well as the major propulsive maneuvers required and the trajectories and energy requirements for manned and unmanned payloads, are reviewed . Another chapter addresses the daunting medical problems andavailable countermeasures for humans embarking on a mission to Mars: the insidious effects of radiation on the human body and the deleterious consequences of bone and muscle deconditioning. Crew selection will be considered, bearing in mind the strong possibility that they may not be able to return to Earth. Still another chapter describes the guidance, navigation, and control system architecture, as well as the lander design requirements and crew tasks and responsibilities required to touch down on the Red Planet.Section 3 looks at the surface mission architectures. Seedhouse describes such problems as radiation, extreme temperatures, and construction challenges that will be encountered by colonists. He examines proposed concepts for transporting cargo and astronauts long distances across the Martian surface using magnetic levitation systems, permanent rail systems, and flying vehicles. In the penultimate chapter of the book, the author explains an adaptable and mobile exploration architecture that will enable long-term human exploration of Mars, perhaps making it the next space-based tourist location.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.

Buch. Zustand: Neu. Neuware - It is becoming increasingly evident that the deficiency of n-3 fatty acids in diet is not only associated with cardiovascular diseases, but also involved in stroke, epilepsy and other neurological and neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, and peroxisomal diseases.In his newest book, Beneficial Effects of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands on the status and therapeutic importance of n-3 fatty acids (major components of fish oil) and their mediators in normal brain and those with neurodegenerative and neuropsychiatric diseases. Farooqui presents the benefits of n-3 fatty acids on Western diet, which is enriched in n-6 fatty acids (major components of vegetable oil) and may promote the above neurological disorders. The book will present readers with cutting edge and comprehensive information on metabolism and roles of neural membrane n-3 fatty acids.

Buch. Zustand: Neu. Neuware - Significant progress has been made in the development of neural prostheses to restore human functions and improve the quality of human life. Biomedical engineers and neuroscientists around the world are working to improve design and performance of existing devices and to develop novel devices for artificial vision, artificial limbs, and brain-machine interfaces. This book, Implantable Neural Prostheses 1: Devices and Applications,ispart one of a two-book series and describes state-of-the-art advances in techniques associated with implantable neural prosthetic devices and their applications. Devices covered include sensory prosthetic devices, such as visual implants, cochlear implants, auditory midbrain implants, and spinal cord stimulators. Motor prosthetic devices, such as deep brain stimulators, Bion microstimu- tors, the brain control and sensing interface, and cardiac electro-stimulation devices are also included. Progress in magnetic stimulation that may offer a non-invasive approach to prosthetic devices is introduced. Regulatory approval of implantable medical devices in the United States and Europe is also discussed.

Buch. Zustand: Neu. Neuware - 39 One of the main challenges facing the member states of the European Union (EU) is 40 the fundamental need to accept the strategic importance of entrepreneurship as a force 41 for regional development and economic growth. Definition of this urgent objective 42 is set in the context of the European Council in Lisbon in March 2000, where there 43 was focus on other operational goals directed to improving performance in European 44 regions in terms of different variables indicating the level of economic activity, 45 particularly employment, real convergence, economic reform, and social cohesion. 46 In 2003, the European Commission (EC) initiated the public debate around the 47 need to strengthen entrepreneurship in the European Union, through publication of 48 the 'Green Paper on Entrepreneurship' in Europe which raised two fundamental 49 questions for reflection by policymakers, entrepreneurs, and individuals: (a) why 50 do so few Europeans set up their own business and (b) why are so few European 51 businesses growing 52 Later, in the context of the 2004 Spring European Council, the European 53 Commission launched the 'Entrepreneurship Action Plan' which aimed fundamen- 54 tally to: (1) change the way society views entrepreneurs, (2) create conditions to 55 encourage more individuals to become entrepreneurs, (3) allow SMEs and entre- 56 preneurs to be more competitive and assume a more important role in determining 57 growth, (4) improve conditions for access to finance by SMEs and entrepreneurs, 58.

Buch. Zustand: Neu. Neuware - George Bush's 1988 campaign pledge, 'Read my lips: no new taxes,' has become a mantra for those who distrust politicians and bureaucrats. The gulf between what political leaders say and do seems to be widening, and in democratic societies around the world, contributing to an atmosphere of cynicism and apathy among the citizenry. Understanding the characteristics and functions of speech in policy processes is a requirement for trying to overcome this problem; indeed, politicians and bureaucrats spend a good proportion of their time and resources discoursing, i.e., writing, speaking, and publishing. However, there has been scant analysis of political discourse; the aim of this book is to fill this analytical gap, by exploring political speech from a variety of perspectives, including normative, epistemological, and empirical. Incorporating insights from economics, political science, philosophy, and law, and evidence from the United States, Canada, France, Italy, Turkey, and the EU, the book addresses a wide variety of timely issues, including:.Fiscal discipline in speeches vs budget balance: Is an improvement (deterioration) of the budget balance preceded by a more (less) fiscally disciplined discourse Revenues and spending forecasted in budget speeches vs realised budget outcomes: Is there a systematic bias If so, how can we explain it Electoral pledges vs actual realisations: Do governments follow up on their electoral pledges Ideological stance in party publications vs spending and revenues of party governments: Do parties of the right and the left speak different languages How can we validly classify a government as of the left or of the right Is there a systematic difference between governments of the right and of the left in terms of their policy Speeches by central bank officers vs monetary policy: Can changes in monetarypolicy be predicted by official speeches The political business cycle: How can taking into consideration the speech-action relationship strengthen (or threaten) our knowledge about electoral and partisan cycles in public spending Other questions explored include: Should policy makers always tell the truth and all the truth What are the benefits and the costs of transparency How can we resolve the apparent contradiction between the democratic demand for transparency and the efficiency requirement of secrecy in many policy areas (budget preparation, monetary policy, foreign policy, security, etc.) Under which conditions is secrecy acceptable in a democratic society To what extent may deception and lies lead to a breach of trust or to power abuse What are the most efficient institutional mechanisms to prevent such abuse Collectively, the authors present new insights for understanding political process and government activity, and suggest avenues for further research.

Buch. Zustand: Neu. Neuware -Quantitative trait locus (QTL) mapping is used to discover the genetic and molecular architecture underlying complex quantitative traits. It has important applications in agricultural, evolutionary, and biomedical research. R/qtl is an extensible, interactive environment for QTL mapping in experimental crosses. It is implemented as a package for the widely used open source statistical software R and contains a diverse array of QTL mapping methods, diagnostic tools for ensuring high-quality data, and facilities for the fit and exploration of multiple-QTL models, including QTL x QTL and QTL x environment interactions. This book is a comprehensive guide to the practice of QTL mapping and the use of R/qtl, including study design, data import and simulation, data diagnostics, interval mapping and generalizations, two-dimensional genome scans, and the consideration of complex multiple-QTL models. Two moderately challenging case studies illustrate QTL analysis in its entirety.The book alternates between QTL mapping theory and examples illustrating the use of R/qtl. Novice readers will find detailed explanations of the important statistical concepts and, through the extensive software illustrations, will be able to apply these concepts in their own research. Experienced readers will find details on the underlying algorithms and the implementation of extensions to R/qtl. There are 150 figures, including 90 in full color.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Buch. Zustand: Neu. Neuware -The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 468 pp. Englisch.

Buch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware -Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.

Buch. Zustand: Neu. Neuware -Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 508 pp. Englisch.

Buch. Zustand: Neu. Neuware -Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 712 pp. Englisch.

Buch. Zustand: Neu. Neuware -During the last decade, a number of novel biophysical methods have been developed that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at the fundamental level of sensitivity, that of a single molecule, has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them.Editorial Advisory Board: Daniel Müller, Cheng Zhu, Claus Seidel, Xiaowei Zhuang, Thomas Schmidt, Nynke Dekker.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 652 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book consists of a number of papers regarding the thermodynamics and structure of multicomponent systems that we have published during the last decade. Even though they involve different topics and different systems, they have something in common which can be considered as the ¿signature¿ of the present book. First, these papers are concerned with ¿difficult¿ or very nonideal systems, i. e. systems with very strong interactions (e. g. , hyd- gen bonding) between components or systems with large differences in the partial molar v- umes of the components (e. g. , the aqueous solutions of proteins), or systems that are far from ¿normal¿ conditions (e. g. , critical or near-critical mixtures). Second, the conventional th- modynamic methods are not sufficient for the accurate treatment of these mixtures. Last but not least, these systems are of interest for the pharmaceutical, biomedical, and related ind- tries. In order to meet the thermodynamic challenges involved in these complex mixtures, we employed a variety of traditional methods but also new methods, such as the fluctuation t- ory of Kirkwood and Buff and ab initio quantum mechanical techniques. The Kirkwood-Buff (KB) theory is a rigorous formalism which is free of any of the - proximations usually used in the thermodynamic treatment of multicomponent systems. This theory appears to be very fruitful when applied to the above mentioned ¿difficult¿ systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Buch. Zustand: Neu. Neuware -Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma.The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -Starting in 1995 numerical modeling of the Earth¿s dynamo has ourished with remarkable success. Direct numerical simulation of convection-driven MHD- ow in a rotating spherical shell show magnetic elds that resemble the geomagnetic eld in many respects: they are dominated by the axial dipole of approximately the right strength, they show spatial power spectra similar to that of Earth, and the magnetic eld morphology and the temporal var- tion of the eld resembles that of the geomagnetic eld (Christensen and Wicht 2007). Some models show stochastic dipole reversals whose details agree with what has been inferred from paleomagnetic data (Glatzmaier and Roberts 1995; Kutzner and Christensen 2002; Wicht 2005). While these models represent direct numerical simulations of the fundamental MHD equations without parameterized induction effects, they do not match actual pla- tary conditions in a number of respects. Speci cally, they rotate too slowly, are much less turbulent, and use a viscosity and thermal diffusivity that is far too large in comparison to magnetic diffusivity. Because of these discrepancies, the success of geodynamo models may seem surprising. In order to better understand the extent to which the models are applicable to planetary dynamos, scaling laws that relate basic properties of the dynamo to the fundamental control parameters play an important role. In recent years rst attempts have been made to derive such scaling laws from a set of numerical simulations that span the accessible parameter space (Christensen and Tilgner 2004; Christensen and Aubert 2006).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.

Buch. Zustand: Neu. Neuware -Terrestrial carbon balance is uncertain at the regional and global scale. A significant source of variability in mid-latitude ecosystems is related to the timing and duration of phenological phases. Spring phenology, in particular, has disproportionate effects on the annual carbon balance. However, the traditional phenological indices that are based on leaf-out and flowering times of select indicator species are not universally amenable for predicting the temporal dynamics of ecosystem carbon and water exchange.Phenology of Ecosystem Processes evaluates current applications of traditional phenology in carbon and H2O cycle research, as well as the potential to identify phenological signals in ecosystem processes themselves. The book summarizes recent progress in the understanding of the seasonal dynamics of ecosystem carbon and H2O fluxes, the novel use of various methods (stable isotopes, time-series, forward and inverse modeling), and the implications for remote sensing and global carbon cycle modeling.Each chapter includes a literature review, in order to present the state-of-the-science in the field and enhance the book¿s usability as an educational aid, as well as a case study to exemplify the use and applicability of various methods. Chapters that apply a specific methodology summarize the successes and challenges of particular methods for quantifying the seasonal changes in ecosystem carbon, water and energy fluxes. The book will benefit global change researchers, modelers, and advanced students.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book aims to give a user friendly tutorial of an interdisciplinary research topic (fronts or interfaces in random media) to senior undergraduates and beginning grad uate students with basic knowledge of partial differential equations (PDE) and prob ability. The approach taken is semiformal, using elementary methods to introduce ideas and motivate results as much as possible, then outlining how to pursue rigor ous theorems, with details to be found in the references section. Since the topic concerns both differential equations and probability, and proba bility is traditionally a quite technical subject with a heavy measure theoretic com ponent, the book strives to develop a simplistic approach so that students can grasp the essentials of fronts and random media and their applications in a self contained tutorial. The book introduces three fundamental PDEs (the Burgers equation, Hamilton¿ Jacobi equations, and reaction¿diffusion equations), analysis of their formulas and front solutions, and related stochastic processes. It builds up tools gradually, so that students are brought to the frontiers of research at a steady pace. A moderate number of exercises are provided to consolidate the concepts and ideas. The main methods are representation formulas of solutions, Laplace meth ods, homogenization, ergodic theory, central limit theorems, large deviation princi ples, variational principles, maximum principles, and Harnack inequalities, among others. These methods are normally covered in separate books on either differential equations or probability. It is my hope that this tutorial will help to illustrate how to combine these tools in solving concrete problems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 172 pp. Englisch.