springer new york springer new york jan 2015 (38 Ergebnisse)

Buch. Zustand: Neu. Neuware -This book provides an introduction to incorporating preference information in Data Envelopment Analysis (DEA) with a special emphasis in Value Efficiency Analysis. In addition to theoretical considerations, numerous illustrative examples are included. Hence, the book can be used as a teaching text as well. Only a modest mathematical background is needed to understand the main principles. The only prerequisites are a) familiarity with linear algebra, especially matrix calculus; b) knowledge of the simplex method; and c) familiarity with the use of computer software.The book is organized as follows. Chapter 1 provides motivation and introduces the basic concepts. Chapter 2 provides the basic ideas and models of Data Envelopment Analysis. The efficient frontier and production possibility set concepts play an important role in all considerations. That's why these concepts are considered more closely in Chapter 3. Since the approaches introduced in this study are inspired by Multiple Objective Linear Programming, the basic concepts of this field are reviewed in Chapter 4. Chapter 5 also compares and contrasts Data Envelopment Analysis and Multiple Objective Linear Programming, providing some cornerstones for approaches presented later in the book. Chapter 6 discusses the traditional approaches to take into account preference information in DEA. In Chapter 7, Value Efficiency is introduced, and Chapter 8 discusses practical aspects. Some extensions are presented in Chapter 9, and in Chapter 10 Value Efficiency is extended to cover the case when a production possibility set is not convex. Three implemented applications are reviewed in Chapter 11.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Counterfeit products represent a growing problem for a wide range of industries. There are many estimates of the size of this problem most of which coalesce around $500-billion annually on a global basis. Overall, a wide range of industries agree that there is a severe problem with the global protection of intellectual property rights (IPR), yet, there have been virtually no attempts to describe all aspects of the problem. This book aims at giving the most complete description of various characteristics of the intellectual property rights (IPR) environment in a global context. The authors believe a holistic understanding of the problem must include consumer complicity to purchase counterfeit, actions of the counterfeiters (pirates) as well as actions (or inaction) by home and host governments, and the role of international organizations and industry alliances. Only after establishing how all the actors in the IPR environment relate to one another can we describe global protection of the intellectual property rights environment and the managerial response of IPR owners and/or industry associations to combat this ongoing problem. The bookconcludes with pragmatic recommendations for protecting intellectual property given the recent trends discussed in the previous chapters, making it of interest to practitioners and policy-makers alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Buch. Zustand: Neu. Neuware -In this volume expert researchers detail in silico methods widely used to study peptides. These include methods and techniques covering the database, molecular docking, dynamics simulation, data mining, de novo design and structure modeling of peptides and protein fragments. Chapters focus on integration and application of technologies to analyze, model, identify, predict, and design a wide variety of bioactive peptides, peptide analogues and peptide drugs, as well as peptide-based biomaterials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Computational Peptidology seeks to aid scientists in the further study into this newly rising subfield.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 352 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This Brief will review the methods that are currently available for the detection, isolation, and typing of pathogenic E. coli with a particular focus on foodborne diseases caused by the Shiga toxigenic E. coli group, which have been implicated in a number of significant outbreaks in recent years. Pathogenic forms of E. coli can cause a variety of diarrheal diseases in hosts due to the presence of specific colonization and virulence factors, and pathogenicity-associated genes, which are generally not present in other E. coli.Six pathotypes of pathogenic E. coli are recognized (Shiga toxigenic E. coli, Enteropathogenic E. coli, Enterotoxigenic E. coli, Enteroinvasive E. coli, Enteroaggregative E. coli and Diffusely Adherent E. coli) and certain strains among these groups are major public health concerns due to the severity of disease that they can cause. Methods to detect and isolate these pathogens from a variety of sources are constantly evolving. In addition, the accumulation of knowledge on these pathogens allows for improved intervention strategies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 116 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The Neolithic period is noted primarily for the change from hunter-gatherer societies to agriculture, domestication and sedentism. This change has been studied in the past by archaeologists observing the movements of plants, animals and people. But has not been examined by looking at the domestic architecture of the time. Along with tracking the movement of sedentism, Neolithic houses are also able to show researchers the beginnings of cultural identity, group representation through the construction and decoration of these structures. Additionally as agriculture moved west and north in this era, the architecture and material culture shows this change and its significance. Chapters are arranged chronologically so that authors can address differences and similarities of their region to neighboring ones. To ensure continuity, authors have framed the chapters around the following considerations: construction materials and architectural characteristics; how houses facilitated or perpetuaSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -¿Business process reengineering (BPR) focuses on redesigning the strategic and value-added processes which transcend the organizational boundaries. It is a cross-functional approach that requires support from almost all the departments of the organization. Business Process Reengineering: Automation Decision Points in Process Reengineering offers a new framework based process reengineering and links it to organization life cycle, process life cycle, and process management. Thisvolume describes the fundamental concepts behind business process reengineering and examines them through case studies, and should appeal to researchers and academics interested in business process reengineering, operations strategy, and organizational restructuring and design.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Toward the late 1990s, several research groups independently began developing new, related theories in mathematical finance.These theories didaway with the standard stochastic geometric diffusion ¿Samuelson¿ market model (also known as the Black-Scholes model because it is used in that most famous theory), instead opting for models that allowed minimax approachesto complement or replace stochastic methods.Among the most fruitful models were those utilizing game-theoretic tools and the so-called interval market model. Over time, these models have slowly but steadily gained influence in the financial community, providing a useful alternative to classical methods.A self-contained monograph, The Interval Market Model in Mathematical Finance: Game-Theoretic Methodsassembles some of the most important results, old and new, in this area of research. Written by seven of the most prominent pioneers of the interval market model and game-theoretic finance, the work provides a detailed account of several closely relatedmodeling techniquesfor an array of problems in mathematical economics. The book isdivided into five parts, which successively address topics including: probability-free Black-Scholes theory; fair-price interval of an option; representation formulas and fast algorithms for option pricing; rainbow options; tychastic approach of mathematical finance based upon viability theory.This book providesa welcome addition to the literature, complementing myriad titles on the market that take a classical approach to mathematical finance. Itis a worthwhile resource for researchers in applied mathematics and quantitative finance,and has also beenwritten in a manneraccessible to financially-inclined readers with a limited technical background.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 364 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book provides a guide to businesses on how to use analytics to help drive from ideas to execution. Analytics used in this way provides ¿full lifecycle support¿ for business and helps during all stages of management decision-making and execution.The framework presented in the book enables the effective interplay of business, analytics, and information technology (business intelligence) both to leverage analytics for competitive advantage and to embed the use of business analytics into the business culture. It lays out an approach for analytics, describes the processes used, and provides guidance on how to scale analytics and how to develop analytics teams. It provides tools to improve analytics in a broad range of business situations, regardless of the level of maturity and the degree of executive sponsorship provided.As a guide for practitioners and managers, the book will benefit people who work in analytics teams, the managers and leaders who manage, use and sponsor analytics, and those who work with and support business analytics teams.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 176 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs. Chapters focus on exploring recent studies that reveal how certain long non protein-coding RNAs accumulate in specific nuclear bodies and regulate the function of the bodies by serving as architectural components or controlling the dynamics of associating protein components. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Nuclear Bodies and Noncoding RNAs: Methods and Protocols serves as a guideline for further study into the sophisticated regulation of gene expression.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 364 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 476 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume seeks to enable the discovery of tools in chemical biology by providing readers with various techniques ranging from initial chemical genetic screening to target identification. To successfully highlight the essential components of the chemical biology tool discovery process, the book is organizes into four parts that focus on platforms for molecular discovery in in vitro cellular systems, in vivo chemical genetic screening protocols, and methods used to discover functional protein targets. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Practical and informative, Chemical Biology: Methods and Protocols seeks to improve the success rate of the chemical biology field through the dissemination of detailed and experiential knowledge.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume provides an overview of modern and emerging methods for production, analysis, and utility of peptide libraries. Chapter focus on methods and techniques for synthesis, genetic expression, hybrid synthesis-expression, examples of modern utility of these libraries, de novo discovery of reactions, hybrid organic-inorganic materials and, emerging tools for the analysis of these libraries by method of genetic selection and next-generation sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Peptide Libraries: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume discusses the many ways to prevent, identify and control hypertension in African Americans, a common and potent risk factor for virtually all forms of cardiovascular-renal diseases. Comprehensive chapters address modifiable risk factors, such as lifestyle changes, especially sodium restriction, and appropriate combination pharmacotherapy. Emerging devices and evidence-based approaches that may also enhance effective blood pressure control and decrease the disparate cardiovascular disease risks, including MI, stroke, HF, and cardiorenal metabolic syndrome and diabetesare also discussed in detail.Written by a wide-range of experts in the field, Hypertension in High Risk African Americans: Current Concepts, Evidence-based Therapeutics and Future Considerations is a valuable resource for clinicians, researchers, health administrators and public health policy leaders to better understand the best practices and unique aspects of risk assessment and treatment of hypertension and co-morbid conditions in African Americans.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 292 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound¿s efficacy. New discoveries in the field, along with the widely recognized need for better and safer pharmaceutical drugs constitute the main motivation for this book. Readers, both beginners and experienced researchers, will receive an updated overview of not only the established, but also the innovative technologies that promise to advance GPCR drug research. This book is organized into two major parts: the introductory part discusses the necessary foundations for the understanding of GPCR action and the rationale behind the design of the available screening assays; and part two provides detailed protocols for different screening approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.Practical and innovative, G Protein-Coupled Receptor Screening Assays: Methods and Protocols reaches out to everyone involved in the discovery of GPCR-active drugs, and provides a transversal overview of the different levels of GPCR signaling addressable in the different screening strategies and presents practical examples of how current assay technologies are contributing to new paradigms in GPCR drug research.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 308 pp. Englisch.

Buch. Zustand: Neu. Neuware -This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 476 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Written by leaders in the field, the third edition of Common Surgical Diseases: An Algorithmic Approach to Problem Solving, provides surgical residents andmedical studentswith a current, concise and algorithmic approach to frequently encountered clinical challenges. Each chapter details every common surgical disease in the form of a succinct text coupled with step-by-step algorithm. It also walks the reader through the evaluation, diagnosis, treatment and follow-up of the most common surgical problems. Thoroughly updated and revised, the third edition focuses on problems most frequently encountered by general surgeons and their residents and students. More factual information is included in the form of charts and tables for quick and easy reference. The section on critical care is updated and expanded. The section on pre-operative considerations has new chapters on how to best manage patient's medications before surgery (anticoagulants, anti-platelet drugs) and prophylaxis of deep venous thrombosis. Other new chapters include access for hemodialysis, adrenal incidentaloma, esophageal cancer, pancreatic cancer, management of abdominal wall defects, hyperglycemia, necrotizing soft tissue infections and SIRS/sepsis. Especially pertinent in todays' medical environment is an understanding of the genetic component of certain cancers and chapters are devoted to screening and treating patients with genetic predispositions to colorectal and breast cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 396 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume reflects the considerable new developments that have taken place in the area of applied neurogenomics, particularly with the rapid progress in next generation sequencing. Beginning with an introduction to the technologies relevant to neurogenomics with an emphasis on next generation sequencing, the book also covers detailed methods relevant to the genomics of neurodegenerative diseases, particularly Alzheimer¿s disease and Huntington¿s disease, targeted sequencing of psychiatric disorders, as well as the role of genomics in the development of personalized neurology. Written in the popular Neuromethods series format, chapters provide the kind of practical description and implementation advice necessary to consistently produce successful results in the lab.Timely and convenient, Applied Neurogenomics serves as an invaluable reference for researchers working in this expanding, dynamic field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 172 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume opens by covering two main types of approaches widely used to determine essential genes: single-gene knockouts and transposon mutagenesis, in both prokaryotes and Candida albicans. Given the significant advancement in the computational predictions of microbial essential genes, the second half of the book examines four main types of approaches: comparative genomics, supervised machine learning, constraint-based methods, and corrections of transposon mutagenesis data, as well as databases and servers that are often used in studying gene essentiality. Written in the highly successful Methods in Molecular Biology series format, chapters include an introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, Gene Essentiality: Methods and Protocols will aid researchers who wish to further our knowledge in this vital field of study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 260 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume provides in-depth protocols for protein labeling techniques and applications, with an additional focus on general background information on the design and generation of the organic molecules used for the labeling step. Chapters provide protocols for labeling techniques and applications, with an additional focus on general background information on the design and generation of the organic molecules used for the labeling step. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Site-Specific Protein Labeling: Methods and Protocols provides a comprehensive overview on the most relevant and established labeling methodologies, and helps researchers to choose the most appropriate labeling method for their biological question.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -¿Over the millennia, from stone tools among early foragers to clays toprized metals and mineral pigments used by later groups, mineral resources have had a pronounced role in the Andean world. Archaeologists have used a variety of analytical techniques on the materials that ancient peoples procured from the earth. What these materials all have in common is that they originated in a mine or quarry. Despite their importance, comparative analysis between these archaeological sites and features has been exceptionally rare, and even more so forthe Andes.Mining and Quarrying in the Ancient Andes focuses on archaeological research at primary deposits of minerals extracted through mining or quarrying in the Andean region. While mining often begins with an economic need, it has important social, political, and ritual dimensions as well. The contributions in this volume place evidence of primary extraction activities within the larger cultural context in which they occurred. This important contribution to the interdisciplinaryliteraturepresents research and analysison the mining and quarrying of various materials throughout the region and through time. Thus, rather than focusing on one material type or one specific site,Mining andQuarrying in the Ancient Andesincorporates a variety of all the aspects of mining, by focusing on the physical, social, and ritual aspects of procuring materials from the earth in the Andean past.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Buch. Zustand: Neu. Neuware -Nolan Wallach's mathematical research is remarkable in both its breadth and depth. His contributions to many fields include representation theory, harmonic analysis, algebraic geometry, combinatorics, number theory, differential equations, Riemannian geometry, ring theory, and quantum information theory. The touchstone and unifying thread running through all his work is the idea of symmetry. This volume is a collection of invited articles that pay tribute to Wallach's ideas, and show symmetry at work in a large variety of areas.The articles, predominantly expository, are written by distinguished mathematicians and contain sufficient preliminary material to reach the widest possible audiences. Graduate students, mathematicians, and physicists interested in representation theory and its applications will find many gems in this volume that have not appeared in print elsewhere.Contributors:D. Barbasch, K. Baur,O. Bucicovschi,B. Casselman, D. Ciubotaru, M. Colarusso, P. Delorme,T. Enright, W.T.Gan,A Garsia,G. Gour,B. Gross,J. Haglund, G. Han,P. Harris, J. Hong, R. Howe, M. Hunziker, B. Kostant, H. Kraft, D. Meyer, R. Miatello, L. Ni, G. Schwarz, L. Small, D. Vogan, N. Wallach, J. Wolf, G. Xin, O. Yacobi.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 568 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book provides a unified mechanics and materials perspective on polymers: both the mathematics of viscoelasticity theory as well as the physical mechanisms behind polymer deformation processes. Introductory material on fundamental mechanics is included to provide a continuous baseline for readers from all disciplines. Introductory material on the chemical and molecular basis of polymers is also included, which is essential to the understanding of the thermomechanical response. This self-contained text covers the viscoelastic characterization of polymers including constitutive modeling, experimental methods, thermal response, and stress and failure analysis. Example problems are provided within the text as well as at the end of each chapter.New to this edition: One new chapter on the use of nano-material inclusions for structural polymer applications and applications such as fiber-reinforced polymers and adhesively bonded structures Brings up-to-date polymer production and sales data and equipment and procedures for evaluating polymer characterization and classification The work serves as a comprehensive reference for advanced seniors seeking graduate level courses, first and second year graduate students, and practicing engineersSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 500 pp. Englisch.

Buch. Zustand: Neu. Neuware -This is a thorough revision of the 2007 publication, and includes five new chapters andbrings all existing chapters completely up to date. There have been many advances in hydropower and renewable technologies since the original publication, and Europe, and particularly Scandinavia, plan many more in the coming years.From a review of the original edition: ¿¿ it is important to note that the author deals well with his selected topics. ¿ I recommend this book to all readers who wish to learn more about the economics of hydroelectric power.' (Amitrajeet A. Batabyal, Interfaces, Vol. 39 (1), January-February, 2009)Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This is the second edition of this proceedings. Contributors include leading names in the field of research, addressing mutiple topics, which were covered at the last Osteoimmunology conference.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -What happens when a chemical is released into the environment It diffuses, disperses, adsorbs, reacts, and/or changes state. To predict and analyze this process, the mathematics of diffusion is applied to lakes, rivers, groundwater, the atmosphere, the oceans, and transport between these media. A sustainable world requires a deep understanding of the transport of chemicals through the environment and how to address and harness this process. This volume presents a succinct and in-depth introduction to this critical topic. Featuring authoritative, peer-reviewed articles from the Encyclopedia of Sustainability Science and Technology, Transport and Fate of Chemicals in the Environment represents an essential one-stop reference for an audience of researchers, undergraduate and graduate students, and industry professionals.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 384 pp. Englisch.

Buch. Zustand: Neu. Neuware -This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 508 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume represents a valuable collection of mobile health (mHealth) emerging technologies. Chapters focus on three main areas of mHealth: technologies for in vitro and environmental testing, mHealth technologies for physiological and anatomical measurements and mHealth technologies for imaging. This book is designed to make mHealth more accessible and understandable to engineers, medical professionals, molecular biologists, chemical, and physical science researchers developing mHealth technologies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, technical information about materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Mobile Health Technologies : Methods in Molecular Biology aims to improve access to medical procedures including early detection, diagnostics and treatment through the development of new portable and accessible devices, and that this will lead to improved health technologies.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 528 pp. Englisch.

Buch. Zustand: Neu. Neuware -This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs.The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volumeprovides an overview of RNA bioinformatics methodologies, including basic strategies to predict secondary and tertiary structures, and novel algorithms based on massive RNA sequencing. Interest in RNA bioinformatics has rapidly increased thanks to the recent high-throughput sequencing technologies allowing scientists to investigate complete transcriptomes at single nucleotide resolution. Adopting advanced computational technics, scientists are now able to conduct more in-depth studies and present them to you in this book. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and equipment, step-by-step, readily reproducible bioinformatics protocols, and key tips to avoid known pitfalls.Authoritative and practical, RNA Bioinformatics seeks to aid scientists in the further study of bioinformatics and computational biology of RNA.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 428 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.