springer netherlands jul 2018 (33 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware -This volume is a critical exposition of the data and analyses from a full decade of rigorous research into how age-related changes at the individual level, along with other factors, contribute to morbidity, disability and mortality risks at the broader population level. After summarizing the state of our knowledge in the field, individual chapters offer enlightening discussion on a range of key topics such as age trajectory analysis in select and general populations, incidence/age patterns of major chronic illnesses, and indices of cumulative deficits and their use in characterizing and understanding the detailed properties of individual aging.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 484 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -NASA¿s Magnetospheric Multiscale (MMS) mission is a four-spacecraft Solar Terrestrial Probe mission to study magnetic reconnection, a fundamental plasma physical process in which energy stored in a magnetic field is converted into the kinetic energy of charged particles and heat. The driver of eruptive solar events such as flares and coronal mass ejections, magnetic reconnection is also the process by which energy is transferred from the solar wind to Earth¿s magnetosphere. Flying in a tetrahedral formation, the four identically instrumented MMS spacecraft measure the plasma, electric and magnetic fields, and energetic particles in the regions of geospace where magnetic reconnection is expected to occur. With interspacecraft distances varying from 400 km to 10 km and instruments capable of making extremely fast measurements (30 ms for electrons), MMS has the spatial and temporal resolution needed to resolve for the first time the microphysics of the electron diffusion region. Here,the magnetic field and the plasma become decoupled, allowing reconnection to occur. During the first of its two mission phases, MMS targets the dayside magnetopause, where the interplanetary and terrestrial magnetic fields reconnect. In the second phase, MMS increases its apogee from 12 RE to 25 RE and probes the nightside magnetosphere, where energy stored in the stretched field lines of the magnetotail is explosively released in magnetospheric substorms. Launched in March 2015 into a low-inclination elliptical orbit, MMS is now in Phase 1 of science operations.This volume, which describes the MMS mission design, observatories, instrumentation, and operations, is aimed at researchers and graduate students in magnetospheric physics and plasma physics. Researchers using the publicly available MMS data will find it particularly useful.Previously published in Space Science Reviews, Volume 199, Nos. 1-4, 2016.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 756 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book offers an introduction to the physics of nonlinear phenomena through two complementary approaches: bifurcation theory and catastrophe theory. Readers will be gradually introduced to the language and formalisms of nonlinear sciences, which constitute the framework to describe complex systems. The difficulty with complex systems is that their evolution cannot be fully predicted because of the interdependence and interactions between their different components.Starting with simple examples and working toward an increasing level of universalization, the work explores diverse scenarios of bifurcations and elementary catastrophes which characterize the qualitative behavior of nonlinear systems. The study of temporal evolution is undertaken using the equations that characterize stationary or oscillatory solutions, while spatial analysis introduces the fascinating problem of morphogenesis.Accessible to undergraduate university students in any discipline concerned with nonlinear phenomena (physics, mathematics, chemistry, geology, economy, etc.), this work provides a wealth of information for teachers and researchers in these various fields.Chaouqi Misbah is a senior researcher at the CNRS (National Centre of Scientific Research in France). His work spans from pattern formation in nonlinear science to complex fluids and biophysics. In 2002 he received a major award from the French Academy of Science for his achievements and in 2003 Grenoble University honoured him with a gold medal. Leader of a group of around 40 scientists, he is a member of the editorial board of the French Academy of Science since 2013 and also holds numerous national and international responsibilities.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 484 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The articles republished in this book survey and summarize recent research in helioseismology as well as studies of the interior structure, dynamics and magnetism of the solar interior that are being tested and refined using the helioseismic results.Helioseismology has in the last few decades become a highly productive technique for studying the Sun¿s interior from observations of the vibrations of its surface. The vibrations are manifestations of resonant modes of the Sun that are continuously excited by turbulent motions in the Sun¿s convection zone, and a plethora of data have been obtained from dedicated ground-based and space-based observing systems.The book will be of particular interest to researchers and graduate students in the fields of helioseismology, solar interior dynamics and the solar dynamo. It will also be of interest to researchers in solar physics, solar activity, stellar physics, astrophysical fluid dynamics and asteroseismology.Originallypublished in Space Science Reviews, Volume 196, Issue 1-4, December 2015Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book offers a ready solution for those who wish to learn more about this fascinating part of our water history and makes accessible to the wider world the traditional knowledge gained from building and maintaining qanats for more than 2,500 years. There is much more here than a summary of the nature and distribution of qanats, and a more extensive journey through the philosophy, methods, tools, and terminology of qanat design and digging than previously assembled.Where does one begin to dig to ensure that the qanat tunnel will flow with water How are practical considerations of landscape factored into the design How are water quality and discharge measured How does excavation proceed through bedrock and unconsolidated soil and how is this knowledge of geology and pedology acquired How are vertical wells and tunnels excavated to maintain proper air supply, light, and water flow How does one deal with special problemslike tunnel collapse, the accumulation of gasses and vapors, and the pooling of water during construction How are tools and gauges designed, maintained, and used How have qanats been incorporated into other structures like watermills, reservoirs, ice houses, and irrigation networks And how are qanats cleaned, extended, maintained through the ages, and incorporated into modern water supplies The great contribution of this work is the story it tells of the ingenuity and practical skills of the qanat masters who for centuries and generations have cut an uncountable number of tunnels through bedrock and alluvium using hand tools and homespun solutions to problems that would vex the most experienced university-trained engineers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 200 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book primarily summarizes the imaging characteristics and theory of parasitic disease, offering a clinical guide and practical approach to understanding, preventing and diagnosing parasitic disease. Through imaging diagnosis and cross-research of imaging with autopsy and pathology, it highlights the chief characteristics and evolution of imaging, which provides primary scientific data for the understanding and research of parasitic disease. Divided into 9 chapters, this volume is fully illustrated with DR, CT and MRI images of different kinds of parasitic diseases, providing a valuable resource for radiologists in this field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 268 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book captures the state of the art of the durability of fibre-reinforced strain-hardening cement-based composites (SHCC) and the durability of structures or structural elements manufactured in full or in part with this class of modern construction materials. Highlights include: Reflection on durability performance of existing applications in patch repair, a water reservoir and highway bridges. Guidelines for tensile testing towards durability assessment of cracked SHCC.- New crack pattern related ingress rate indices for water and chloride into cracked SHCC. The influence of low and high temperatures on SHCC durability performance. The mechanism of crack control reducing ASR and corrosion rate, and results on chloride-induced corrosion of embedded steel reinforcement.- Self-healing of cracks in SHCC. A conceptual durability design framework for SHCC and R/SHCC structures andmembers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book offers readers a comprehensive overview, and an in-depth understanding, of suitable methods for quantifying and characterizing saline aquifers for the geological storage of CO2. It begins with a general overview of the methodology and the processes that take place when CO2 is injected and stored in deep saline-water-containing formations. It subsequently presents mathematical and numerical models used for predicting the consequences of CO2 injection.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 576 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This is a practical book with clear descriptions of the most commonly used nonmarket methods. The first chapters of the book provide the context and theoretical foundation of nonmarket valuation along with a discussion of data collection procedures. The middle chapters describe the major stated- and revealed-preference valuation methods. For each method, the steps involved in implementation are laid out and carefully explained with supporting references from the published literature. The final chapters of the book examine the relevance of experimentation to economic valuation, the transfer of existing nonmarket values to new settings, and assessments of the reliability and validity of nonmarket values.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 516 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery.This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book comprises 26 articles on the EChO science cases, mission pre-assessment and assessment, phase-studies, the payload, the instrumentation and software. They are reprints of articles published in a special issue on EChO ¿ Exoplanet Characterisation Observatory of the journal Experimental Astronomy.Originally published in Experimental Astronomy, Volume 40, Nos. 2-3 (2015)Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 524 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This is the first publication ever focusing strictly on the creep behaviour in cracked sections of Fibre Reinforced Concrete (FRC). These proceedings contain the latest scientific papers about new testing methodologies, results and conclusions of multiple experimental campaigns and recommendations about significant factors of long-term behaviour, experiences from more than ten years of creep testing and some reflections about future perspectives on this topic. This book is an essential reference for all researchers of creep behaviour on FRC.This volume is the result of the efforts of the RILEM TC 261-CCF, that has been working since 2014 to develop standardized methodologies and guidelines to compare results from different laboratories and get a better understanding of the significant parameters related to creep of FRC.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 264 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The reader will discover a comprehensive and multifaceted overview of the history of the development of anticancer drugs deeply influenced by the cell concept of cancer and future directions for the development of new anticancer drugs. First, this book documents the scientific progress in biological science over the last 70 years and the influence this progress had in cancer research. Summaries and charts of important discoveries complete this overview. Furthermore, this book outlines the process of anticancer drug development with a focus on the characteristic drug groups of each era, related to advancements of chemistry and biological sciences. This book also provides brief mechanism of action of drugs, illustrated by comprehensive timelines and conceptual cartoons. This book finally sums up the limitations of the current anticancer drug development and seeks new directions for anticancer drug discovery, considering under the systemic view of cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Physicochemical Properties of Ionic Liquid Mixtures is a useful handbook that contains the following features: - the physicochemical properties and property models of mixtures containing ionic liquids - supplemented by a comprehensive database of properties listing ionic liquid systems collected from more than 800 dependable literature sources - over 60,000 data entries on 39 types of physicochemical properties for 1388 mixtures, including binary, ternary, quaternary and other mixtures.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 1132 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book links tropical agri-chain dynamics ¿ with which CIRAD and AFD have been involved for decades ¿ to that of sustainable development. Increased environmental and social concerns urge agri-chain actors and development practitioners to design innovations, and public and private actors to invent regulations in connection with agri-chains to improve sustainability.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 384 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume addresses major evolutionary changes that took place during the Ediacaran and the Paleozoic. These include discussions on the nature of Ediacaran ecosystems, as well as the ichnologic signature of evolutionary radiations, such as the Cambrian explosion and the Great Ordovician biodiversification event, the invasion of the land, and the end-Permian mass extinction.This volume set provides innovative reviews of the major evolutionary events in the history of life from an ichnologic perspective. Because the long temporal range of trace fossils has been commonly emphasized, biogenic structures have been traditionally overlooked in macroevolution. However, comparisons of ichnofaunas through geologic time do reveal the changing ecology of organism-substrate interactions. The use of trace fossils in evolutionary paleoecology represents a new trend that is opening a window for our understanding of major evolutionary radiations and mass extinctions. Trace fossils provide crucial evidence for the recognition of spatial and temporal patterns and processes associated with paleoecologic breakthroughs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 376 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book systematically and comprehensively discusses the biological, epidemiological and clinical characteristics of the hepatitis E virus (HEV). It presents current knowledge of HEV and explores experimental methods, treatment and prevention of HEV. First identified in the 1980s and cloned in 1990, HEV is the causative agent of Hepatitis E, which mainly occurs in developing regions, such as Southeast Asia, Middle East and Africa, and significantly affects the health of the people in these areas. It is estimated that a third of the world¿s population has been infected with HEV, which is transmitted via the fecal-oral route and can infect both human and animals.The book provides an overview of HEV from benchside to bedside. It is a valuable resource for researchers in the field and those in the pharmaceutical industry developing HEV vaccines, as well as physicians involved in identifying and treating those infected with the virus.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide.This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book covers both classical and modern analytical methods in nonlinear systems. A wide range of applications from fundamental research to engineering problems are addressed. The book contains seven chapters, each with miscellaneous problems and their detailed solutions. More than 100 practice problems are illustrated, which might be useful for students and researchers in the areas of nonlinear oscillations and applied mathematics. With providing real world examples, this book shows the multidisciplinary emergence of nonlinear dynamical systems in a wide range of applications including mechanical and electrical oscillators, micro/nano resonators and sensors, and also modelling of global warming, epidemic diseases, sociology, chemical reactions, biology and ecology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book includes topics in nanophysics, nanotechnology, nanomaterials, sensors, biosensors, security systems, and CBRN agents detection. There have been many significant advances in the past two years and some entirely new directions of research are just opening up.Recent developments in nanotechnology and measurement techniques now allow experimental investigation of the physical properties of nanostructured materials.The book presents new methods for the detection of chemical, biological, radiological and nuclear (CBRN) agents using chemical and biochemical sensors. Identification, protection and decontamination are the main scientific and technological responses for the modern challenges of CBRN agents.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 372 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book includes topics in nanophysics, nanotechnology, nanomaterials, sensors, biosensors, security systems, and CBRN agents detection. There have been many significant advances in the past two years and some entirely new directions of research are just opening up.Recent developments in nanotechnology and measurement techniques now allow experimental investigation of the physical properties of nanostructured materials.The book presents new methods for the detection of chemical, biological, radiological and nuclear (CBRN) agents using chemical and biochemical sensors. Identification, protection and decontamination are the main scientific and technological responses for the modern challenges of CBRN agents.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 372 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The main objective of this book is to present the distribution and diversity of major soil types in Serbia. It focuses on giving a detailed description of the physical, chemical and biological properties of soil and their geomorphological forms, as well as the geological characteristics of parent material. An integrative approach is used to study the interaction between climate, vegetation and geology in soil formation. Special attention is paid to human-induced soil degradation due to the erosion and contamination of soils in Serbia. The book includes a harmonization of national soil classification systems, with the FAO, WBR and ESD systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This is the first comprehensive science-based textbook on the biology and ecology of the Baltic Sea, one of the world¿s largest brackish water bodies. The aim of this book is to provide students and other readers with knowledge about the conditions for life in brackish water, the functioning of the Baltic Sea ecosystem and its environmental problems and management. It highlights biological variation along the unique environmental gradients of the brackish Baltic Sea Area (the Baltic Sea, Belt Sea and Kattegat), especially those in salinity and climate.pt;font-family:'Arial','sans-serif'; color:#262626'>The first part of the book presents the challenges for life processes and ecosystem dynamics that result from the Baltic Seäs highly variable recent geological history and geographical isolation. The second part explains interactions between organisms and their environment, including biogeochemical cycles, patterns of biodiversity, genetic diversity and evolution, biological invasions and physiological adaptations. In the third part, the subsystems of the Baltic Sea ecosystem ¿ the pelagic zone, the sea ice, the deep soft sea beds, the phytobenthic zone, the sandy coasts, and estuaries and coastal lagoons ¿ are treated in detail with respect to the structure and function of communities and habitats and consequences of natural and anthropogenic constraints, such as climate change, discharges of nutrients and hazardous substances. Finally, the fourth part of the book discusses monitoring and ecosystem-based management to deal with contemporary and emerging threats to the ecosystem¿s health.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 716 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book elucidates how cyberGIS (that is, new-generation geographic information science and systems (GIS) based on advanced computing and cyberinfrastructure) transforms computation- and data-intensive geospatial discovery and innovation. It comprehensively addresses opportunities and challenges, roadmaps for research and development, and major progress, trends, and impacts of cyberGIS in the era of big data. The book serves as an authoritative source of information to fill the void of introducing this exciting and growing field. By providing a set of representative applications and science drivers of cyberGIS, this book demonstrates how cyberGIS has been advanced to enable cutting-edge scientific research and innovative geospatial application development. Such cyberGIS advances are contextualized as diverse but interrelated science and technology frontiers. The book also emphasizes several important social dimensions of cyberGIS such as for empowering deliberative civic engagement and enabling collaborative problem solving through structured participation. In sum, this book will be a great resource to students, academics, and geospatial professionals for leaning cutting-edge cyberGIS, geospatial data science, high-performance computing, and related applications and sciences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -It is an edited book with chapters written by multi-disciplinary specialists in their specific subject areas. It covers development of IPM components and packaging them for individual vegetable crops specifically targeted to tropical countries. Scientific background for IPM components or tactics will be included. There will be case studies of IPM packages developed and implemented in different countries. The concept of IPM has been in existence for the past six decades; however, a practical holistic program has not been developed and implemented for vegetable crops, in the developing countries. Currently the IPM adoption rate in the tropics is minimal and there is a need for implementation of IPM technologies that are environmentally safe, economical, and socially acceptable. We believe that adoption and implementation of IPM provided in this book will lead to significant reduction in crop losses and mitigate adverse impacts of pesticide use in the tropics. This book is an outcome 20 years of research, development and implementation of the IPM CRSP, a project supported by USAID and administered by Virginia Tech in several developing countries along the tropical belt in Africa, Asia, Latin America and the Caribbean. ¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The work of the RILEM Technical Committee (TC -236 BBM) was dedicated to the study of construction materials made from plant particles. It considered the question whether building materials containing as main raw material recyclable and easily available plant particles are renewable.This book includes a state-of-the-art report and an appendix. The state-of-the-art report relates to the description of vegetal aggregates. Then, hygrothermal properties, fire resistance, durability and finally the impact of the variability of the method of production of bio-based concrete are assessed. The appendix is a TC report which presents the experience of a working group. The goal was to define testing methods for the measurement of water absorption, bulk density, particle size distribution, and thermal conductivity of bio aggregates. The work is based on a first round robin test of the TC-BBM where the protocols in use by the different laboratories (labs) are compared. p>Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 300 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book addresses nearly every aspect of Y. pestis, approaching it from a new perspective. Topics covered include the history, epidemiology, physiology, ecology, genome, evolution, pathogenesis, host-pathogen interaction, big-data-driven research, vaccines, clinical aspects and future research trends. For centuries, scientists have sought to determine where Y. pestis, the most well-known bacterium and one that has caused a number of high-mortality epidemics throughout human history, comes from, what it is and how it causes the disease. This book works to answer these questions with the help of cutting-edge research results. It not only describes the history of plagues, but also stresses plagues¿ effects on human civilization and explores the interaction of Y. pestis with hosts, vectors and the environment to reveal the evolution and pathogenesis. The book offers a valuable guide for researchers and graduate students studying Y. pestis, and will also benefit researchers from other fields, such as infectious diseases, other pathogens and system biology, sharing key insights into bacterial pathogen studies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 400 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume addresses major evolutionary changes that took place during the Mesozoic and the Cenozoic. These include discussions on major evolutionary radiations and ecological innovations on land and at sea, such as the Mesozoic marine revolution, the Mesozoic radiation of vertebrates, the Mesozoic lacustrine revolution, the Cenozoic radiation of mammals, the evolution of paleosol biotas, and the evolution of hominins. The roles of mass extinctions at the end of the Triassic and at the end of the Cretaceous are assessed.This volume set provides innovative reviews of the major evolutionary events in the history of life from an ichnologic perspective. Because the long temporal range of trace fossils has been commonly emphasized, biogenic structures have been traditionally overlooked in macroevolution. However, comparisons of ichnofaunas through geologic time do reveal the changing ecology of organism-substrate interactions. The use of trace fossils in evolutionary paleoecology represents a new trend that is opening a window for our understanding of major evolutionary radiations and mass extinctions. Trace fossils provide crucial evidence for the recognition of spatial and temporal patterns and processes associated with paleoecologic breakthroughs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins.The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously.This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 520 pp. Englisch.