Springer jun 2004 (12 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - In Walking in Space: Development of Space Walking Techniques, David Shayler provides a comprehensive overview and analysis of EVA techniques, available for the first time in a readable form - other than NASA publications. The author draws on original documentation, personal interviews of astronauts with experience of EVAs, and accounts by those involved in suit design, EVA planning and operations. Moving on from the pioneering of EVA techniques during the Gemini programme, the author describes the basic requirements in terms of the equipment that every spacewalker needs, the development of training techniques - currently all completed on Earth - the surface explorations of the Moon by the Apollo astronauts and the numerous activities performed by Shuttle astronauts and those aboard the Salyut and Mir Space Stations, such as satellite servicing, equipment upgrading and repair missions. He also describes the development of techniques for ensuring crew safety during EVAs and looks ahead to future EVAs from the International Space Station and the development of new technology, including robotic assistance.…

Taschenbuch. Zustand: Neu. Neuware - The NATO Advanced Research Workshop, 'Effective Scientific Communication Related to Recent Challenges and Activities in the Military Sector,' was the result of close collaboration between defense and environmental officials in the United States and the Slovak Republic. It was recognized that effective solutions to environmental problems are achieved through the proper application of science, including the communications and the social sciences. Workshop was co-directed by Messrs. Ronald A. Kreizenbeck of US EPA and Lubomir Kusnír of Slovak Ministry of Defense. Workshop topics were grouped into five major topic areas including 1) Environmental Policy Perspectives, 2) Environmental Management Systems and Public Participation, 3) Environmental Security, 4) Environmental Decision Support, and 5) Protection of Nature and Natural Systems. Delegates from nineteen countries assembled to explore these topics at the Hotel Danube in Bratislava from April 22-26, 2003. A total of forty six delegates were in attendance, twenty from NATO countries and twenty six from Partners for Peace countries. The final program included technical sessions using a presentation and dialog format, work groups, field trips, and networking sessions. There were twenty nine technical presentations divided into seven sessions, and these form the basis for these proceedings. xiii Acknowledgments The organizers of this Advanced Research Workshop acknowledge the support of two major financial sponsors, the NATO Science Programme and the U. S. Department of Defense (USDOD) under the Partners for Peace Program (PfP).…

Buch. Zustand: Neu. Neuware - Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders. For example, the CGG repeat is expanded in fragile X syndrome at the 5' untranslated region (UTR) of its causal gene. In myotonic dystrophy, it is the CTG repeat that is expanded at the 3' UTR of its causal gene. The CAG repeat was also found expanded in coding regions of the genes responsible for X-linked spinal and bulbar muscular atrophy, Huntington's disease, spinocerebellar ataxia, and other disorders. On the other hand, expansion of the GAA repeat was identified in the intron of the gene responsible for the Friedreich's ataxia. For these trinucleotide repeat diseases, the longer the trinucleotide expansion, the earlier the age of onset and the more severe the syndrome. Thus, these findings that showed the intriguing link between a particular trinucleotide expansion and its associated neurological disorders have led to a new field of intensive study. Active research addressing the underlying mechanisms for trinucleotide repeat diseases has employed various approaches ranging from DNA biochemistry to animal models for the diseases. In particular, animal models for the triplet repeat diseases have provided excellent resources not only for understanding the mechanisms but also for exploring therapeutic interventions. …

Buch. Zustand: Neu. Neuware - Carrying on the high standards of the much-praised first edition of Nitric Oxide Protocols, Aviv Hassid has brought together a panel of expert researchers and clinician scientists to describe in step-by-step detail the latest methodologies for the measurement of nitric oxide--and the enzyme that produces it-in biological tissues and fluids. The authors take advantage of the latest methodologies for the quantitation of biological fluids and tissues, including capillary electrophoresis, microcoaxial electrodes, in vivo measurement of nitric oxide in exhaled air, confocal microscopy, gas chromatography, in situ hybridization, and real-time polymerase chain reaction. Chapters on the measurement of the novel products of nitric oxide, such as nitrated proteins, S-nitrosylated proteins, and dioxygen-dependent NO metabolism, are also included. Additional chapters address the expression of nitric oxide synthase via the use of viral vectors in gene therapy for erectile dysfunction and cancer, as well as in retrovirus, adenovirus, or adenoassociated virus-mediated expression of nitric oxide synthase in vivo. The protocols follow the successful Methods in Molecular Biology(TM) series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Nitric Oxide Protocols, 2nd ed., offers investigators and clinican/scientists a gold-standard collection of readily reproducible analytical techniques for measuring levels of nitric oxide and determining its manifold functions and effects.…

Buch. Zustand: Neu. Neuware - A masterly survey of the last 13 years of Very Long Baseline Interferometry, reviewed in light of the most advanced astronomical observations. Topics covered include: Nonthermal emission from extragalactic radio sources; Principles of synchrotron emission in relation to astrophysics; Theory of relativistic jets; Young, powerful radio sources and their evolution; Scintillation in extragalactic radio sources; Radio and optical interferometry; Radio polarimetry; Unified schemes; Deep fields; Tropospheric and ionospheric phase calibration; Supernovae; VLBI for geodesy and geodynamics.…

Buch. Zustand: Neu. Neuware - In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available.This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression. …

Buch. Zustand: Neu. Neuware - The present volume contains the presentations of a NATO advanced Research Workshop (ARW) entitled 'The invasion of the Black, Mediterranean and Caspian Seas by the American Ctenophore, Mnemiopsis leidyi Agassiz: a multidisciplinary perspective and a comparison with other aquatic invasions', held on 24 - 26 June 2002 in Baku (Azerbaijan). The meeting was nanced by the NATO Division for Scienti c and Environmental Affairs (Brussels); substantial logistic support was provided by the CEP (Caspian Environmental Program) of the GEF in Baku. The Mediterranean, Black, and Caspian Seas represent three fragments of the former Tethys Sea, and are thus of great interest to understanding the evolution of the entire region where Eurasia, Africa and the Arabian Peninsula meet. While the Mediterranean is a typical marine environment, with salinity even a little above the world ocean's, the Black Sea is a brackish meromictic lake, and the Caspian is a lake with a saline gradient extending from a freshwater basin in the North to a brackish water basin in the South. Intense shing activity takes place in all three seas, while maritime traf c through the Dardanelles and Bosporus, and via the Lenin Canal (between the Don and Volga rivers) to the Caspian Sea has become greatly intensi ed in the course of the last few decades.…

Buch. Zustand: Neu. Neuware - The 21st century will witness the unprecedented marketing of therapeutic drugs developed from cannabinoids and the endocannabinoid system. Cannabinoids is a timely volume, which represents a comprehensive review of the most important issues in cannabinoid research as well as those of most likely therapeutic relevance. For the first time, the multi-faceted aspects of cannabinoid chemistry, biology and medicine are presented in one volume. Key topics of discussion: -major families of phytocannabinoids; -pharmacological activity of phytocannabinoids; -interactions of phytocannabinoids with their proposed molecular target; -components of the endocannabinoid system; -molecular mechanisms of the endocannabinoid system; -Physiological and pathological role of endocannabinoids; -industrial applications of studies on the cannabinoids; -therapeutic uses of agonists and antagonists of cannabinoids receptors. This book is a must for graduate and pre- and post-doctoral students in disciplines ranging from organic and natural product chemistry, pharmacology, biochemistry and medicine.…

Buch. Zustand: Neu. Neuware - This book is the proceedings of the Falk Symposium No. 138 on 'State of the Art of Hepatology: Molecular and Cell Biology' (part of the XII International Falk Liver Week 2003 in honour of Hans Popper's 100th birthday, held on October 20--11, 2003), and reflects the tremendous advances in the science of hepatology both at the molecular as well as the cellular level. The book comprises four major sections. In Section I, the basic aspects of liver cell biology are covered, including RNA metabolism, regeneration, transport and metabolic functions, as well as fibrogenesis and malignant transformation. In Section II, the novel field of stem cell plasticity and cell therapy for liver diseases is discussed in detail, including stem cell biology, hepatocyte transdifferentiation from extrahepatic stem cells and their therapeutic use for liver cell repopulation, as well as hepatocyte transplantation. In Section III, novel therapeutic strategies for liver cirrhosis and hepatocellular carcinoma are presented, including the reversal of liver fibrosis, oncolytic biotherapy and different concepts of gene therapy for hepatocellular carcinoma. In Section IV, novel aspects of gene therapy and prevention of liver diseases are addressed, including small interfering RNAs, ribozymes, antisense oligonucleotides, as well as DNA vaccination. An international faculty of outstanding scientists from different research areas presents the state of the art on these most important aspects of hepatology and their perspectives for future developments. Molecular and cell biology are at the very centre of research developments in modern hepatology and are of interest and importance to both basic scientists as well as clinicians involved in patient care.…

Buch. Zustand: Neu. Neuware - Complementarity, duality, and symmetry are closely related concepts, and have always been a rich source of inspiration in human understanding through the centuries, particularly in mathematics and science. The Proceedings of IUTAM Symposium on Complementarity, Duality, and Symmetry in Nonlinear Mechanics brings together some of world's leading researchers in both mathematics and mechanics to provide an interdisciplinary but engineering flavoured exploration of the field's foundation and state of the art developments. Topics addressed in this book deal with fundamental theory, methods, and applications of complementarity, duality and symmetry in multidisciplinary fields of nonlinear mechanics, including nonconvex and nonsmooth elasticity, dynamics, phase transitions, plastic limit and shakedown analysis of hardening materials and structures, bifurcation analysis, entropy optimization, free boundary value problems, minimax theory, fluid mechanics, periodic soliton resonance, constrained mechanical systems, finite element methods and computational mechanics. A special invited paper presented important research opportunities and challenges of the theoretical and applied mechanics as well as engineering materials in the exciting information age. Audience: This book is addressed to all scientists, physicists, engineers and mathematicians, as well as advanced students (doctoral and post-doctoral level) at universities and in industry. …

Taschenbuch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware - There is a growing understanding that the progress of the conventional silicon technology will reach its physical, engineering and economic limits in near future. This fact, however, does not mean that progress in computing will slow down. What will take us beyond the silicon era are new nano-technologies that are being pursued in university and corporate laboratories around the world. In particular, molecular switching devices and systems that will self-assemble through molecular recognition are being designed and studied. Many labora tories are now testing new types of these and other reversible switches, as well as fabricating nanowires needed to connect circuit elements together. But there are still significant opportunities and demand for invention and discovery be fore nanoelectronics will become a reality. The actual mechanisms of transport through molecular quantum dots and nanowires are of the highest current ex perimental and theoretical interest. In particular, there is growing evidence that both electron-vibron interactions and electron-electron correlations are impor tant. Further progress requires worldwide efforts of trans-disciplinary teams of physicists, quantum chemists, material and computer scientists, and engineers.…