Springer jan 1984 (5 Ergebnisse)
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Taschenbuch. Zustand: Neu. Neuware - It is often the case - perhaps more often than not - that new ideas arrive long before there is the me ans to clothe and deli ver them. We can think ofLeonardo da Vinci's drawings of helicopters and submarines among many other examples. Computer-Assisted Learning (CAL) is an example of an ide…a which has had a particularly long gestation. As I will illustrate early in the book, the principles of CAL were really first discovered by Socrates. As a formal method of teaching, the Socratic method disappeared for over two millennia until the 1950s. It was then revived in the form ofProgrammed Learning (PL) which resulted from the researches ofB. F. Skinner at Harvard University. Even then, PL was premature. In the 1950s and 60s, methods were devised, such as teaching machines and various sorts ofPL text books, and there was a mushrooming of PL publishing at that time. For a complex of reason- economic, logistical and technical-PL also largely disappeared from the mid- 60s, although it continued in a few specialized areas ofteaching and industrial training. However, during the same period, PL quietly transformed itselfinto CAL. But the computerized form was not capable of mass dissemination until recently hecause personal microcomputers did not have sufficient internal memory sizes. That situation has now changed very dramatically and 128K microcomputers are becoming cheap and widely available. Cheap memory chips of256K and 1024K cannot be far away, either.
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Taschenbuch. Zustand: Neu. Neuware - Opening Lecture.- 1 Attentuation in the Control of Gene Expression in Animal Viruses.- Reassortment of Viruses with Divided Genome.- 2 The Use of Reassortant Bunvaviruses to Deduce Their Coding and Pathogenic Potentials.- 3 Genetic Diversity of Buvnaviruses and Mechansisms of Genetic Variatio…n.- 4 Variations In Rift Valley Fever Virus.- Molecular Mechanisms In Acute, Persistent and Latent Infections.- 5 Pathogenic Aspects of Murine Coronavirus Infection In Rats.- 6 Persistent Paramvxovirus Infection In Vitro and In Vivo.- 7 Factors Involved In Measles Virus Persistence.- 8 Mechanism of Adeno-Associated Virus Latent Infection.- 9 Host Range Transition of Lymphotropic Minute Virus of Mice During Persistent Infection In L-Cells.- 10 Transplantation of Mouse Genes into Rat Cells Chronically Infected by Moloney Leukemia Virus (Mo-MuLV).- Promoters in Pathogenesis.- 11 Transforming Genes of Retroviruses and Cancer Cells.- 12 Control Elements for the Expression of DNA Tumor Viruses.- 13 Non-Expressed Tumor Virus Oncogenes Can Be Activated by Tumor Promoters.- 14 Rearrangement and Activation of a Cellular Oncogene.- 15 Pathogenicity of Vesicular Stomatitis Virus Is Potentially Mediated by Wild-Type Leader RNA which Inhibits Initiation of Transcription.- 16 Structural Features of Picornavirus RNA Involved in Pathogenesis: A Very High Affinity Binding Site for A Messenger RNA-Recognizing Protein.- 17 Molecular Approach to Virulence: Isolation and Characterization of Avirulent Mutants of Rabies Virus.- Cleavae of Glycoprotein In Pathogenesis.- 18 Studies on The Structure and Activities of Influenza Virus Haemagglutinin.- 19 On The Role of Viral Envelope Proteins in Pathogenesis.- 20 On The Pathogenicity of Avian Influenza Virus.- 21 Glycoproteins of Venezuelan Equine Encephalitis(VEE) Virus: Molecular Structure and Function in Virus Pathogenicity and Host Immunity.- Viral Enzymes In Pathogenesis.- 22 Isolation and Characterization of the Viral RNA Dependent RNA Polymerases from Cells Infected with Either the Mahoney or Sabin Attenuated (LSc,2ab) Strains of Poliovirus Type 1.- 23 Herpes Simplex Virus Type 1 Thymidine Kinase Controls Virus Pathogenesis and Latency in the Neivous System.- 24 Round Table Discussion.- Author Index.
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Buch. Zustand: Neu. Neuware - 1 Antibiotics associated with Clostridium difficile mediated diarrhoea and/or colitis.- 2 Spectrum of disease.- 3 Diagnosis and treatment of antimicrobial agent-associated diarrhea and colitis.- 4 Detection, isolation and identification of Clostridium difficile.- 5 Detection of Clostridium difficile… toxins.- 6 Epidemiology of antimicrobial agent-associated diarrhea and colitis.- 7 Typing Clostridium difficile.- 8 Clostridium difficile and colonization resistance.- 9 Characteristics of the toxins of Clostridium difficile.- 10 Interaction of Clostridium difficile toxin B (cytotoxin) with cultured cells.- 11 Animal models of Clostridium difficile infection.- 12 The pathology of antibiotic-associated colitis.- Concluding remarks The unanswered questions.- Reference section.
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Buch. Zustand: Neu. Neuware - THE PHILOSOPHY OF QUALITY ASSURANCE IN THE BLOOD BANK H. F. Taswell One year before this symposium, Cees Smit Sibinga and I began to discuss an approach to quality assurance in the blood bank which we felt would be both important and practical and could serve as the basis for the choice of subjects…to be presented in the symposium. As an introduction to this book, I would like to outline our approach, the subjects chosen and the rationale behind our choice. What is the fundamental purpose of a blood bank and trans fusion service Simply stated, the purpose of a blood bank and transfusion service and of a quality assurance program in blood banking is, for the one to provide and, the other to assure safe and effective transfusion therapy. This objective is in contrast to that of other clinical laboratories. The objective in a clinical chemistry laboratory is to produce accurate test results which will be meaningful to the clinician taking care of his patient. In most clinical laboratories, therefore, the goals of a quality assurance program are largely quantitative, that is, to assure accurate numerical test results. In contrast, in the blood bank, the goals of quality assurance are primarily qualitative, that is, to assure safe and effective transfusion. As a result, two somewhat different approaches to quality assurance are necessary.
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Buch. Zustand: Neu. Neuware - Many advances in vitamin D physiology and biochemistry have been made in recent years. Vitamin D metabolites and analogs have found increasing application in clinical medicine. The purpose of this text is to review what is known about vitamin D physiology and draw attention to areas of vitamin D res…earch that have changed within the last 2-3 years. Additionally, information concerning clinical aspects of vitamin D is also presented. More than 40 scientists have generously contributed chapters to this text; I thank them for their efforts. As might be expected, not everyone has the same point of view. Finally, I would like to acknowledge the secretarial and editorial efforts of Mrs. Cheryl Collins without whom this book would not have been completed. CONTRIBUTORS ETSUKO ABE, Department of Biochemistry, School of Dentistry, Showa University, 1-5-8, Hatanodai, Shinagawa-KU, Tokyo 142, Japan DAVID J. BAYLINK, Department of Medicine, Loma Linda University, Loma Linda, CA, and Pettis Veterans Hospital, 11201 Benton Street, Loma Linda, CA, 92357, USA NORMAN H. BELL, Department of Medicine, Medical University of South Carolina and Veterans Administration Medical Center, 109 Bee Street, Charleston, SC, 29403, USA WARNER M. BURCH, Jr. , Departments of Medicine and Physiology, Duke Univer sity Medical Center, Durham, NC, 27710, USA DAVID V. COHN, ICCRH, Inc. , 1238 Wyncrest Court, Arden Hills, MN, 55112, USA ROBERT A. CORRADINO, Department of Physiology, New York State College of Veterinary Medicine, Cornell University, 720 VRT, Ithaca, NY, 14853, USA HECTOR F.
