Springer apr 2002 (16 Ergebnisse)
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Buch. Zustand: Neu. Neuware - The essays collected in this volume explore the multiple connections and parallels between the histories of the American south and the Italian south. Leading historians of the two regions consider the comparability of issues as diverse as the stereotypes relating to the two souths, the ideology of t…he landed elites, the treatment of labourers on large landed estates, the importance of gender in the understanding of social relations, and the connections between progressive political forces and between migratory movements across the two sides of the Atlantic.
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Buch. Zustand: Neu. Neuware - As Clinton left office there was little consensus even among Democrats as to the significance of his political legacy. He was keen to stress that enduring changes had been made to American society. Critics, however, were less convinced that Clintonism had developed an integrated vision of governance…. This book examines whether the Clinton experience does illustrate the value of the New Democrat and Third Way agenda.
Sprache: Englisch
Verlag: Springer Nature B.V. Apr 2002, 2002
Serie: Buch 189 von 260 - The Springer International Series in Engineering and Computer Science
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Buch. Zustand: Neu. Neuware - Java is an exciting new object-oriented technology. Hardware for supporting objects and other features of Java such as multithreading, dynamic linking and loading is the focus of this book. The impact of Java's features on micro-architectural resources and issues in the design of Java-specific archi…tectures are interesting topics that require the immediate attention of the research community. While Java has become an important part of desktop applications, it is now being used widely in high-end server markets, and will soon be widespread in low-end embedded computing.Java Microarchitectures contains a collection of papers providing a snapshot of the state of the art in hardware support for Java. The book covers the behavior of Java applications, embedded processors for Java, memory system design, and high-performance single-chip architectures designed to execute Java applications efficiently.
Sprache: Englisch
Verlag: Springer Nature B.V. Apr 2002, 2002
- Hardcover
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Buch. Zustand: Neu. Neuware - Because the search for safe and effective chemotherapeutic agents has been hindered by antimicrobial resistance and toxic harm, there is a growing need to understand how the immune system can be manipulated to control infections, particularly HIV. In Immunotherapy for Infectious Diseases, Jeffrey M.… Jacobson, md, and a group of leading researchers active in the field review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by using chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function. Also discussed are immunotherapy for other viral infections, virus-associated malignancies, bacterial infections and sepsis, tuberculosis, and fungal infections.Comprehensive and cutting-edge, Immunotherapy for Infectious Diseases reviews all the current state-of-the-art developments occurring in this rapidly evolving field and helps set the stage for the early development of better immunologically based therapies for infections.
Sprache: Englisch
Verlag: Springer Us Apr 2002, 2002
Serie: Buch 86 von 260 - The Springer International Series in Engineering and Computer Science
- Hardcover
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Buch. Zustand: Neu. Neuware - With the rapid growth of networking and high-computing power, the demand for large-scale and complex software systems has increased dramatically. Many of the software systems support or supplant human control of safety-critical systems such as flight control systems, space shuttle control systems, a…ircraft avionics control systems, robotics, patient monitoring systems, nuclear power plant control systems, and so on. Failure of safety-critical systems could result in great disasters and loss of human life. Therefore, software used for safety critical systems should preserve high assurance properties. In order to comply with high assurance properties, a safety-critical system often shares resources between multiple concurrently active computing agents and must meet rigid real-time constraints. However, concurrency and timing constraints make the development of a safety-critical system much more error prone and arduous. The correctness of software systems nowadays depends mainly on the work of testing and debugging. Testing and debugging involve the process of de tecting, locating, analyzing, isolating, and correcting suspected faults using the runtime information of a system. However, testing and debugging are not sufficient to prove the correctness of a safety-critical system. In contrast, static analysis is supported by formalisms to specify the system precisely. Formal verification methods are then applied to prove the logical correctness of the system with respect to the specification. Formal verifica tion gives us greater confidence that safety-critical systems meet the desired assurance properties in order to avoid disastrous consequences.
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Buch. Zustand: Neu. Neuware - Landscape ecology and conservation biology are rapidly developing disciplines, and a current synthesis of principles and applications in these two fields is needed under one cover. Many managers are not applying principles of landscape ecology in efforts to conserve biota, yet the loss of biological… diversity could be reduced if broad-scale processes and patterns were consistently considered in management and conservation decisions. Bringing together insights from leaders in landscape ecology and conservation biology, this book explains how our knowledge about landscape ecology can help us understand, manage and maintain biodiversity. Beyond explaining pertinent concepts of landscape ecology and biological conservation and describing examples of their use in management, research and planning, this book also distills principles for applying landscape ecology in conservation, identifies gaps in current knowledge and provides research approaches to fill those voids. The book is divided into five parts: the first part introduces the book and discusses what landscape ecology is and why it is important to biological conservation. The second deals with multiple scales, connectivity and organism movement. The third part discusses landscape change and how this affects biodiversity, and the fourth part covers conservation planning. The final part presents a synthesis that identifies overarching principles, pervasive constraints and realistic prospects for applying landscape ecology in biological conservation. Conservationists, land-use planners, and ecologists will find this book to be an essential resource.
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Buch. Zustand: Neu. Neuware - In the past dozen years, the field of international mental health has been transformed from a sub-discipline that attracted only a handful of anthropologists, psychiatrists, and psychologists, into a field that has now become a major concern in international public health. The World Mental Health Ca…sebook will serve as a resource for those engaged in the widening efforts to address the burden of mental disorders in low-income countries. The case studies contained here describe: the 'Shanghai Model' of psychiatric rehabilitation for persons with schizophrenia, an extraordinary mental health program for poor patients in Lima, Peru who are undergoing treatment for multi-drug resistant tuberculosis, how Guatemalan refugee women in Mexico were trained to become mental health promoters, the development of mental health services in primary care settings in Nepal, the attempts to improve the lives of women in India through literacy programs, the radical reform of psychiatric services in Trieste, Italy, and research from Fiji and Hong Kong that shows how traditional practices can lower the prevalence of post-partum depression. Each case history, through concrete and pragmatic examples, offers lessons that can inform the functioning of services elsewhere. In general, the Casebook, will also encourage others to undertake careful documentation and evaluation of programs so that the mistakes of the past can be avoided, and the successes replicated.
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Buch. Zustand: Neu. Neuware - In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QT…L). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis. Statistical methods for the analysis of quantitative trait locus (QTL), in conjunction with genome-wide screening technologies, are today yielding exciting results in the study of human disease, experimental organisms, and agriculture. In Quantitative Trait Loci: Methods and Protocols, Drs. Nicola Camp and Angela Cox have assembled a highly experienced panel of statistical geneticists who demonstrate in a step-by-step fashion how to use this powerful methodology and associated software for the detection and fine mapping of quantitative trait loci. Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and useful variations and/or extensions to standard methods are included that ease the reader toward understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov chain Monte Carlo method for joint linkage and segregation analysis. Up-to-date and highly practical, Quantitative Trait Loci: Methods and Protocols makes available to nonmathematical investigators a step-by-step guide to the productive use today of all the latest techniques for localizing genes involved in complex quantitative traits.
Sprache: Englisch
Verlag: Springer Nature B.V. Apr 2002, 2002
Serie: Buch 13 von 96 - Cancer Drug Discovery and Development
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Buch. Zustand: Neu. Neuware - Recent scientific discoveries concerning therapeutically relevant protein targets that contribute to cancer pathology have opened new possibilities in the search for effective cancer treatments. In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading…basic researchers, pharmaceutical scientists, and clinical oncologists provide, in an easy-to-understand format, a detailed account of these latest research developments and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell and including recently elucidated enzymes involved with chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene and chromatin control targets, and angiogenesis. Among the targets considered are E2F, Myc oncoproteins, hypoxic signaling pathways, Mdm2 and ARF, the AP-1 family of transcription factors, histone deacetylase, histone acetyl transferase, apoptin, and nuclear ß-catenin signaling.Up-to-date and insightful, Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins shows clearly how our new understanding of critical molecular targets in cancer cells can be applied to cancer drug discovery to provide new drug discovery platforms both for future development and for new target-based medicines for cancer patients.
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Buch. Zustand: Neu. Neuware - PCR Cloning Protocols, Second Edition, updates and expands Bruce White's best-selling PCR Cloning Protocols (1997) with the newest procedures for DNA cloning and mutagenesis. Here the researcher will find readily reproducible methods for all the major aspects of PCR use, including PCR optimization,…computer programs for PCR primer design and analysis, and novel variations for cloning genes of special characteristics or origin, with emphasis on long distance PCR and GC-rich template amplification. Also included are both conventional and novel enzyme-free and restriction site-free procedures to clone PCR products into a range of vectors, as well as state-of-the-art protocols to facilitate DNA mutagenesis and recombination, and to clone the challenging uncharacterized DNA flanking a known DNA fragment. In the post-genomic era, PCR has become the method of choice not only for cloning existing genes, but also for generating a wide array of novel genes by mutagenesis and/or recombination within the genes of interest. PCR Cloning Protocols, Second Edition, updates and expands Bruce White's best-selling PCR Cloning Protocols (1997) with the newest procedures for DNA cloning and mutagenesis. Here the researcher will find readily reproducible methods for all the major aspects of PCR use, including PCR optimization, computer programs for PCR primer design and analysis, and novel variations for cloning genes of special characteristics or origin, with emphasis on long-distance PCR and GC-rich template amplification. Also included are both conventional and novel enzyme-free and restriction site-free procedures to clone PCR products into a range of vectors, as well as state-of-the-art protocols to facilitate DNA mutagenesis and recombination and to clone the challenging uncharacterized DNA flanking a known DNA fragment. Powerful applications of PCR in library construction and sublibrary generation and screening are also presented. Authoritative and up-to-date, PCR Cloning Protocols, Second Edition, constitutes a gold-standard collection of the fastest, simplest, and most popular methods for isolating genes from all biological samples and creating novel genes from them by mutagenesis/recombination-essential methods for today's study of functional genomics, gene expression, protein structure-function relationships, protein engineering, and molecular evolution.
- Hardcover
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Buch. Zustand: Neu. Neuware - Discusses how new digital art work can be developed, and looks at the implications for art and future technologies.
Sprache: Englisch
Verlag: Springer Nature B.V. Apr 2002, 2002
Serie: Buch 225 von 241 - NATO Science Series II: Mathematics, Physics and Chemistry
- Hardcover
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Buch. Zustand: Neu. Neuware - A review of the electrical properties, performance and physical mechanisms of the main silicon-on-insulator (SOI) materials and devices. Particular attention is paid to the reliability of SOI structures operating in harsh conditions. The first part of the book deals with material technology and desc…ribes the SIMOX and ELTRAN technologies, the smart-cut technique, SiCOI structures and MBE growth. The second part covers reliability of devices operating under extreme conditions, with an examination of low and high temperature operation of deep submicron MOSFETs and novel SOI technologies and circuits, SOI in harsh environments and the properties of the buried oxide. The third part deals with the characterization of advanced SOI materials and devices, covering laser-recrystallized SOI layers, ultrashort SOI MOSFETs and nanostructures, gated diodes and SOI devices produced by a variety of techniques. The last part reviews future prospects for SOI structures, analyzing wafer bonding techniques, applications of oxidized porous silicon, semi-insulating silicon materials, self-organization of silicon dots and wires on SOI and some new physical phenomena.
Sprache: Englisch
Verlag: Springer Nature B.V. Apr 2002, 2002
Serie: Buch 40 von 241 - NATO Science Series II: Mathematics, Physics and Chemistry
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Buch. Zustand: Neu. Neuware - Recent advances in electrochemistry and materials science have opened the way to the evolution of entirely new types of energy storage systems: rechargeable lithium-ion batteries, electrochroms, hydrogen containers, etc., all of which have greatly improved electrical performance and other desirable…characteristics. This book encompasses all the disciplines linked in the progress from fundamentals to applications, from description and modelling of different materials to technological use, from general diagnostics to methods related to technological control and operation of intercalation compounds. Designing devices with higher specific energy and power will require a more profound understanding of material properties and performance. This book covers the status of materials and advanced activities based on the development of new substances for energy storage.
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Buch. Zustand: Neu. Neuware - Animal cell technology is a growing discipline of cell biology, which aims not only to understand structures, functions, and behaviours of differentiated animal cells but also to ascertain their ability to be used for industrial and medical purposes. The goal of animal cell technology includes accom…plishments of clonal expansion of differentiated cells with useful ability, optimisation of their culture conditions, modulation of their ability for production of medically and pharmaceutically important proteins, and the application of animal cells to gene therapy, artificial organs, and functional foods. This volume gives the reader a complete review of the present state of the art in Japan and other countries where this field is well advanced. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers, and other disciplines related to animal cell culture, working in either academic environments or in industries of biotechnology and pharmacy.
Sprache: Englisch
Verlag: Springer Apr 2002, 2002
Serie: Buch 77 von 151 - Solid Mechanics and Its Applications
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Buch. Zustand: Neu. Neuware - This volume constitutes the Proceedings of the IUTAM Symposium on 'Analytical and Computational Fracture Mechanics of Non-homogeneous Materials', held in Cardiff from 18th to 22nd June 2001. The Symposium was convened to address and place on record topical issues in analytical and computational aspe…cts of the fracture of non-homogeneous materials as they are approached by specialists in mechanics, materials science and related fields. The expertise represented in the Symposium was accordingly very wide, and many of the world's greatest authorities in their respective fields participated. Given the extensive range and scale of non-homogeneous materials, it had to be focussed to enhance the quality and impact of the Symposium. The range of non-homogeneous materials was limited to those that are inhomogeneous at the macroscopic level and/or exhibit strain softening. The issues of micro to macro scaling were not excluded even within this restricted range which covered materials such as rock, concrete, ceramics and composites on the one hand, and, on the other, those metallic materials whose ductile fracture is strongly influenced by the presence of inhomogeneities. The Symposium remained focussed on fundamental research issues of practical significance. These issues have many common features among seemingly disparate non-homogeneous materials.
Sprache: Deutsch
Verlag: Springer Berlin Heidelberg, Springer Berlin Heidelberg Apr 2002, 2002
- Softcover
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Taschenbuch. Zustand: Neu. Neuware - Das 7. Heidelberger Symposium über Hämostaseologie in der Anästhesiologie hatte als zentrales Thema die disseminierte Gerinnungsaktivierung, wie sie bei Sepsis im Rahmen der Verbrauchskoagulopathie immer noch ein wichtiges klinisches Problem ist. Die disseminierte Gerinnungsaktivierung stellt… sich immer wieder mit zwei Gesichtern dar: Zum einen ist sie ein Paradepferd der wissenschaftlichen Hämostaseologie, das Modell, an dem die Gerinnung erforscht wird, zum anderen ist sie immer wieder für Enttäuschungen und Überraschungen gut, denn kaum meint man, ein Molekül und seine Wirkung verstanden zu haben, so lehrt die klinische Erfahrung, dass dies nicht so einfach ist, wie man ursprünglich dachte.
