Springer apr 1988 (5 Ergebnisse)

Buch. Zustand: Neu. Neuware - Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.…

Buch. Zustand: Neu. Neuware - The field of catheter ablation has grown In a rather helter-skelter fashion. Ablative techniques were applied in patients before basic bioelectric and cellular electrophysiologic effects were fully defined. Since the introduction of this technique into clinical medicine in 1982, happily, a wealth of basic information has become available, and it was thought prudent to summarize existing data in the form of a text. The purpose of this text is to provide for a concise summary of both the basic and clinical experiences to date. It was simply not possible to include chapters from many workers who have made outstanding contributions in this area. For this, I offer my profound apolo gies. I do wish, however, to acknowledge the outstanding work of Drs. Bharati and Lev who provided us with a sound understanding of the histolo gic effects of various energy delivery systems. Their seminal observations allowed us to bring this technique to clinical fruition.…

Buch. Zustand: Neu. Neuware - It is our conviction - based on many years of teaching and practical experience - that professional skill in forestry will develop more rea dily and more efficiently if forestry students are presented with a clear understanding, at an early stage, of the impact of the physical factors that both enhance and inhibit forestry activities. Tnis know ledge is best aquired by adressing the physical world of forestry with a set of analytical tools through which an almost infinite number of variables can be listed in order, be measured and their interaction be explored and resolved. This is the main purpose of this joint effort, presented in two volumes, Part I and Part II. Part I is analytic, written as a basic text for undergraduates in cour ses such as logging, transport, forest engineering and even forest ma nagement. It deals with the fundamentals of technology in forestry as determined by the physical environment. Briefly it can be visualized as the application of forestry wi thin the parameters: space, time and energy. Forestry is a process with a long time horizon. Free solar energy creates biomass which, with the aid of other forms of energy, is converted into products and services. A knowledge of the dependecies and interactions is indiGpensible for the forestry profession. The analytic approach serves two purposes: to bring about a clear un derstanding of the real world of forest and to develop tools through which efficiency and productivity can be explored and improved.…

Taschenbuch. Zustand: Neu. Neuware - As noted in the Foreword, this report is the second of several volumes resulting from this study of future health care technology. The purpose of the study, as formulated by the STG, was to analyze future health care technology. Part of the task was to develop an 'early warning system' for health care technology. The primary goal of the project was to develop a list or description of a number of possible and probable future health care technologies, as well as information on their importance. Within the limits of time and money, this has been done. This report is the description of anticipated future health care technologies. However, given the vast number of possible future health care technologies, complete information on the importance of each area could not be developed in any depth for all technology. Therefore, four specific technologies were chosen and were prospectively assessed. These future technologies were examined in more depth, looking particularly at their future health and policy implications. Subsequently, the project was extended to September 1987, and two additional technologies are being assessed.…

Buch. Zustand: Neu. Neuware - In recent years there has been a growing interest in and concern for the development of a sound spatial statistical body of theory. This work has been undertaken by geographers, statisticians, regional scientists, econometricians, and others (e. g. , sociologists). It has led to the publication of a number of books, including Cliff and Ord's Spatial Processes (1981), Bartlett's The Statistical Analysis of Spatial Pattern (1975), Ripley's Spatial Statistics (1981), Paelinck and Klaassen's Spatial Economet~ics (1979), Ahuja and Schachter's Pattern Models (1983), and Upton and Fingleton's Spatial Data Analysis by Example (1985). The first of these books presents a useful introduction to the topic of spatial autocorrelation, focusing on autocorrelation indices and their sampling distributions. The second of these books is quite brief, but nevertheless furnishes an eloquent introduction to the rela tionship between spatial autoregressive and two-dimensional spectral models. Ripley's book virtually ignores autoregressive and trend surface modelling, and focuses almost solely on point pattern analysis. Paelinck and Klaassen's book closely follows an econometric textbook format, and as a result overlooks much of the important material necessary for successful spatial data analy sis. It almost exclusively addresses distance and gravity models, with some treatment of autoregressive modelling. Pattern Models supplements Cliff and Ord's book, which in combination provide a good introduction to spatial data analysis. Its basic limitation is a preoccupation with the geometry of planar patterns, and hence is very narrow in scope.…