rsc publishing nov 2011 (18 Ergebnisse)

Buch. Zustand: Neu. Neuware - Precise and accurate nomenclature is a vital aspect of chemistry. IUPAC nomenclature provides unequivocal names for all kinds of chemical structures. This requires a rational basis from which comprehensible names can be developed. Written by leading world authorities, Principles of Chemical Nomenclature enables teachers and students to obtain a sound training in IUPAC nomenclature. It outlines IUPAC recommendations for application in the principle branches of chemistry: organic, inorganic, organometallic, and polymer. It also includes some basic biochemical nomenclature. The book clearly explains the fundamental principles of nomenclature methods and enables the reader to apply them accurately and with confidence. The book is replete with examples for guidance and there are extensive tables to direct the reader to information quickly. The new edition takes a slightly different approach to the original. Discussions of other nomenclatures used in specific industries have been added. These include the IUPAC International Chemical Identifier (InChI) and the Preferred IUPAC Names (PINs). Nomenclature, just like chemistry, is a subject that develops continually. New classes of compound require new adaptations of nomenclature and IUPAC tries to provide these. The changes in IUPAC recommendations since publication of the first edition have been incorporated. This expansion of coverage required additional expertise so the writing of the new edition has been divided amongst a group of specialist writers. Aimed at chemistry teachers and students at all levels, this book advises on the best presentation of formulae and chemical graphics. Although rather advanced for school pupils, their teachers will find it useful.

Taschenbuch. Zustand: Neu. Neuware - One of the most important parts of British heavy industry today is our railway system. Its constant appearances in news bulletins, its enormous appeal to fans or 'enthusiasts', its permanent role in the lives of most of us, and its economic significance today, all underline its importance. This book describes the vital relationship between chemistry and the railway industry, all very recently discovered. It shows that the railway system would simply have not been possible without chemical inputs. This discovery about a huge revenue-earning industry in Britain came from rare documents recently unearthed and other archival material and the book contains many rare illustrations and vast amounts of previously unpublished material. A great many engineers contributed to the enormous technological development which occurred in the railway industry between 1830 and 1923, but working alongside the engineers were the chemists, and in certain critical areas their contribution to this development was vital. It is a contribution which up until now has not been adequately recognised, and this book puts the record straight.

Taschenbuch. Zustand: Neu. Neuware - The sun provides solar energy which is clean and environmentally friendly and can be directly used to produce thermal as well as electrical power. It is also directly the main source of all renewable energy sources discussed in this book. Due to global industrialization and the sharp increase of CO2, there is an increasing need to develop less polluting renewable energy sources for our long term survival and to balance the ecological system. This book is a unique and complete book covering renewable energy resources and contains a detailed analysis of energy and exergy, CO2 mitigation, and CO2 credit of various renewable energy sources. It is an ideal reference for teaching renewable energy to engineering and science students, as well as a reference book for scientists and professionals doing self study on the subject.

Taschenbuch. Zustand: Neu. Neuware - This book is a practical, easy to use guide for readers with limited experience of molecular modelling. It will provide students at the undergraduate and early postgraduate chemistry level with a similar entry to modelling. The needs of independent readers are catered for by the inclusion of instructions for acquiring and setting up a suitable computer. Unlike many other textbooks in this field, the authors avoid extensive discussion around complex mathematical foundations behind the methods, choosing instead to provide the reader with the choice of methods themselves. To further these aims of the book, compact discs are included that provide a comprehensive suite of modelling software and datasets. The continuing interest of the pharmaceutical industry in molecular modelling in early stage drug design is recognized by the inclusion of chapters Medicinal Chemistry and Drug Discovery. There is a chapter on modelling of the solid state, a subject that is also of importance for pharma, where problems due to polymorphism in the crystalline forms of drugs are often encountered in the later design stages.

Buch. Zustand: Neu. Neuware - CD and MCD spectroscopy can provide key information about the conformations and electronic states of chromophore containing molecules. However, the theory has remained too challenging and inaccessible for many organic chemists and biochemists and only a few researchers have carried out detailed quantitative analyzes of their spectral data. This is not surprising as people who excel at spectroscopic theory usually lack the skills set required to design and synthesize the molecules that would be most appropriate for describing and explaining the theory of CD and MCD spectroscopy. Most of the books that have been written on the subject have, therefore, been based on very dense sets of mathematical equations. This timely book rectifies that situation by summarizing the relationship between the different types of spectra and by describing in detail the qualitative and quantitative methods which can readily be used to analyze CD and MCD spectral data. During the last decade the authors have successfully synthesized several molecules to illustrate key points related to the theory of CD and MCD spectroscopy, resulting in this definitive book providing key practical knowledge in a readily accessible style. It is aimed primarily at organic chemists and biochemists and provides the required reading for researchers active in the field. In the introduction, the book describes the types of information that can be derived from CD and MCD spectroscopy. After a detailed explanation of the theory of electronic absorption spectroscopy, it then provides practical in depth examples of the various analytical methods that can be carried out with CD and MCD spectral data. This makes the theory of these techniques much more accessible for researchers who do not specialize in physical chemistry.

Buch. Zustand: Neu. Neuware - The books describe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume Two describes human biomonitoring of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress, and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei, and individual susceptibility.

Buch. Zustand: Neu. Neuware - When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause encrustation, plaque formation and aseptic loosening on the surface. These problems contribute to the patient's trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions, although this is often masked by other factors. This book describes the fundamental principles of this phenomenon before providing a more detailed scientific background. It covers the development of the relevant technologies and their applications in therapeutic devices such as MRSA-resistant fabrics, cardiovascular and urological stents, orthopaedic implants, and grafts. Academic and graduate students interested in producing a selective biological response at the surface of a given biomaterial will find the detailed coverage of interactions at the nanometre scale useful. Practitioners will also benefit from guidance on how to pre-screen many inappropriate designs of biomedical devices long before any expensive, animal or potentially risky clinical trials. Enhanced by the use of case studies, the book is divided in to four topical sections. The final section is dedicated to the application of related topics making the book unique in its pragmatic approach to combining high end interdisciplinary scientific knowledge with commercially viable new technologies. Contributing to the newly emerging discipline of 'nanomedicine', the book is written not only by experts from each relevant specialty but also by practitioners such as clinicians and device engineers from industry.

Buch. Zustand: Neu. Neuware - Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine or blood. The analytical methods for detection of substances in biological media have been considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two-volume handbook provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books describe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume One describes current human biomonitoring activities in Germany, Romania, France, Canada, India, and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern related to adverse effects from exposures to endocrine disruptors and genotoxic compound. The book also includes chapters on biomarkers of specific exposures in a range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, lead, PAHs, dioxins, mercury and arsenic.

Buch. Zustand: Neu. Neuware - Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.

Buch. Zustand: Neu. Neuware - This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.

Buch. Zustand: Neu. Neuware - Immobilization of chiral catalysts is an important tool for improving the overall efficiency of catalytic processes. However, heterogeneous catalysts often suffer from decreased activities and supported, but still homogeneous catalysts can help overcome this issue. This book covers the most important concepts of homogeneous supported catalysis with an emphasis on enantioselective processes. It describes the state-of-the-art and latest developments in each area while critically evaluating the strengths and weaknesses of this important method. The book encompasses ionically-tagged catalysts, supported organocatalysts, supported ionic liquid phases, catalysis using soluble polymers, catalytic dendrimers, fluorous catalysts, water soluble catalysts and non-covalent immobilization methods. Potential developments and ideas for the future are also highlighted. There is a growing demand for effective and recyclable catalysts so this book, covering all the important methods in the field of supported homogeneous catalysis, will appeal to many researchers in academia and industry.

Buch. Zustand: Neu. Neuware - This book is the proceedings of the World Conference on 'New developments in Acacia Gums Research and Products' held in September 2010. Dealing with the latest information on polysaccharide gum research, particularly focused on gum Arabic, this book covers the production, identification, classification and application of these important carbohydrate polymers. Written by the world's leading experts, bringing together all the latest information in the field, it will be an essential reference for researchers in industry and academia interested in the continued advances in this area.

Buch. Zustand: Neu. Neuware - Naturally occurring or manufactured through chemical and/or physical processes, particulate materials are substances consisting of individual particles which have significance to the global economy, society and environments. Due to the diversity and intrinsic nature, manufacturing, handling and processing of particulate materials still face numerous challenges. Aimed at addressing these challenges, this book contains a selection of papers discussing the state-of-the-art research in particulate materials science that were presented at the UK-China Particle Technology Forum III held at Birmingham, UK in 2011. Classified into four distinct topics namely synthesis, characterisation, processing and modelling, the chapters showcase the advances in these areas including a range of advanced synthesis methods for example, spray-pyrolysis, supercritical fluid synthesis assisted with ultrasound, continuous synthesis using supercritical water, hydrothermal synthesis of nano-particulate materials and jet milling. For characterisation, various methods for characterising particulate materials at both particle and system levels are introduced and how these properties affect the behaviour of particulate materials in various processes, such as inhalation, filling, and consolidation, are discussed. In the processing section, recent advances such as capsule filling, micro-dosing, dry granulation, roll compaction, milling, and more are presented. The last section concerns mathematical and numerical modelling in particulate materials, for which the book includes both analytical methods and advanced numerical methods, such as discrete element methods (DEM), computational fluid dynamics (CFD), lattice Boltzmann methods (LBM), coupled DEM/CFD and DEM/LBM, and their applications.Particulate Materials is aimed at research communities dealing with these diverse materials, and scientists and engineers in powder handling industries, such as pharmaceutical, food, fine chemical and detergents.

Buch. Zustand: Neu. Neuware - In recent years, several new concepts have emerged in the field of stratospheric ozone depletion, creating a need for a concise in-depth publication covering the ozone-climate issue. This monograph fills that void in the literature and gives detailed treatment of recent advances in the field of stratospheric ozone depletion. It puts particular emphasis on the coupling between changes in the ozone layer and atmospheric change caused by a changing climate. The book, written by leading experts in the field, brings the reader the most recent research in this area and fills the gap between advanced textbooks and assessments.

Buch. Zustand: Neu. Neuware - With the rapidly escalating costs of drug discovery and development together with spiralling delivery, quantitative approaches hold the promise of shifting the balance of success, to enable drug discovery to maintain its economic viability. Drug Design Strategies: Quantitative Approaches will provide a useful summary of the current state-of-the-art in quantitative approaches to drug design, and future opportunities. It will provide an inspiration to drug design practitioners to apply careful design, to make best use of the quantitative methods that are currently available, while continuing to improve them. The book begins with a comprehensive overview of quantitative approaches to drug design and describes the development of key concepts such as 'drug-like properties', quantitative structure-activity relationships and molecular modelling, and in particular, structure-based design approaches to guide lead optimisation. How you manage and describe chemical structures, underpins all quantitative approaches to drug design and these are described in Chapters 6-8. The value of a quantitative approach, and also the challenge, is to describe the confidence in any prediction, and methods to assess predictive model quality are described in chapter 9. The later chapters describe the application of quantitative approaches to describing and optimising potency, selectivity, drug metabolism and pharmacokinetic properties and toxicology, and the design of chemical libraries to feed the screening approaches to lead generation that underpin modern drug discovery. Finally the impact of bioinformatics, current status of predicting ligand affinity direct from the protein structure, and the application of quantitative approaches to predicting environmental risk are also discussed. The book will be essential reading for medicinal and computational chemists, and all those involved in drug discovery and development in the pharmaceutical industries.

Buch. Zustand: Neu. Neuware - Metal phosphonate chemistry is a highly interdisciplinary field, as it encompasses several other areas, such as materials chemistry, gas storage, pharmaceutics, corrosion control, classical chemical synthesis, X-ray crystallography, powder diffraction, etc. It has also acquired additional significance due to 'Metal-Organic Frameworks', as evidenced by the hundreds of papers published each year. This book fills the gap in the literature by summarising, in a concise way, the latest developments in the field. Metal phosphonate chemistry has seen impressive growth in the last 15-20 years and there is a clear need to systematize and organize all this growth. This unique book accomplishes just that need - edited by two experts, it includes contributions from other experienced researchers and organises, categorises and presents in an attractive way the latest hot topics in metal phosphonate chemistry and related applications. With an extensive bibliography, it is a great reference for academic and industrial researchers as well as students working in the field and will act as a starting point for further exploration of the literature. It is also of great interest to scientists working in the broader area of metal-organic frameworks and their applications.

Buch. Zustand: Neu. Neuware - There are ~8 million deaths every year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. The aim of this book is to present a state-of-the-art review of drug discovery in respect of NTDs and to highlight best practice to guide ongoing drug discovery effort, to raise awareness and promote debate in neglected disease areas that still have unmet medical need. Neglected Diseases and Drug Discovery, details nearly all of the key diseases that fall into this class. It sets out to make a critical appraisal of ongoing research with a focus on the key science that has led to breakthroughs, especially from a medicinal chemistry perspective. The book covers in great depth current efforts in the malaria, trypanosomatid, flavivirus and tuberculosis fields, wherein an upsurge in research efforts has been evident in recent times. Additionally, there is some focus on the 'neglected' neglected diseases, notably diarrhea, helminths, HIV (in worldwide terms) and lower respiratory tract infections. In respect of the more publicised disease areas such as malaria there is a review of each disease and established compounds, mechanistic classes and new horizons. In the more under-publicised areas the chapters seek to highlight the pressing need for better and more widely available treatments Written by a team of experienced experts the book will prove to be an invaluable guide to successful practice in NTDs highlighting ongoing and new drug discovery efforts in this field. It will aid both researchers and the general reader, by summarising the key learning to date and provide a clear overview of the challenges that remain.

Buch. Zustand: Neu. Neuware - The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.