rsc publishing jul 2011 (5 Ergebnisse)

Buch. Zustand: Neu. Neuware - Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed 'amyloid') in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitable pharmacological target. However, drugs aimed at simply removing excess metals or interfering in amyloid deposition were unsuccessful and scientists have been forced to review the classical hypothesis. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease. Furthermore, small molecules with the potential to control metal homeostasis, or metallostasis, are expected to provide the framework for the design of novel proteostasis regulators. This book provides an up-date on the latest developments in this fast moving field. Traditional views concerning the relationship between the physio-pathological cycles of copper, zinc, iron, aluminium and the evolution of life, are compared with emerging ideas in the neuroscience of metal ions. Topics covered emphasize the importance of metals and oxidation chemistry to neuroscientists as well as providing a wider, multidisciplinary background to chemists who are attracted by these fascinating subjects. The text starts with a chapter on chemical evolution, the brain and metallomics which describes the brain's natural defences to adverse conditions. It then goes on to cover the chemistry and biology of proteostasis, environmental factors, and the role played by membranes in protein misfolding. The remaining chapters cover the role of metals and oxidative stress in Alzheimer's Disease, Parkinsonism, ALS and other neurodegenerative diseases. The book is suitable for academics, those working in industry, and postgraduate students.

Buch. Zustand: Neu. Neuware - Membranes already have important applications in artificial organs, the processing of biotechnological products, food manufacture, waste water treatment, and seawater desalination. Their uses in gaseous mixture separations are, however, far from achieving their full potential. Separation of air components, natural gas dehumidification and sweeting, separation and recovery of CO2 from biogas, and H2 from refinery gases are all examples of current industrial applications. The use of membranes for reducing the greenhouse effect and improving energy efficiency has also been suggested. New process intensification strategies in the petrochemical industry have opened up another growth area for gas separation membrane systems and membrane reactors. This two volume set presents the state-of-the-art in membrane engineering for the separation of gases. It addresses future developments in carbon capture and utilization, H2 production and purification, and O2/N2 separation. Topics covered include the: applications of membrane gas separation in the petrochemical industry; implementation of membrane processes for post-combustion capture; commercial applications of membranes in gas separations; simulation of membrane systems for CO2 capture; design and development of membrane reactors for industrial applications; Pd-based membranes in hydrogen production; modelling and simulation of membrane reactors for hydrogen production and purification; novel hybrid membrane/pressure swing adsorption process for gas separation; molecular dynamics as a new tool for membrane design, and physical aging of membranes for gas separations. Volume 2 looks at problems combined with membrane reactors.

Buch. Zustand: Neu. Neuware - Concerns about environmental pollution, global climate change and hazards to human health have increased dramatically. This has lead to a call for change in chemical processes including those that are part of chemical analysis. The development of analytical chemistry continues and every new discovery in chemistry, physics, molecular biology, and materials science brings new opportunities and challenges. Yet, contemporary analytical chemistry does not consume resources optimally. Indeed, the usage of toxic chemical compounds is at the highest rate ever. All this makes the emerging field of green chemistry a 'hot topic' in industrial, governmental laboratories as well as in academia. This book starts by introducing the twelve principles of green chemistry. It then goes on to discuss how the principles of green chemistry can be used to assess the 'greenness' of analytical methodologies. The 'green profile' proposed by the ACS Green Chemistry Institute is also presented. A chapter on 'Greening' sample preparation describes approaches to minimizing toxic solvent use, using non-toxic alternatives, and saving energy. The chapter on instrumental methods describes existing analytical approaches that are inherently green and making non-green methods greener. The final chapter on signal acquisition describes how quantitative structure-property relationship (QSPR) ideas could reduce experimental work thus making analysis greener. The book concludes with a discussion of how green chemistry is both possible and necessary. Green Analytical Chemistry is aimed at managers of analytical laboratories but will also interest teachers of analytical chemistry and green public policy makers.

Buch. Zustand: Neu. Neuware - Research and literature on nanomaterials has exploded in volume in recent years. Nanotubes (both of carbon and inorganic materials) can be made in a variety of ways. Many of these properties, such as high mechanical strength and interesting electronic properties relate directly to potential applications. Nanowires have been made from a vast array of inorganic materials and provide great scope for further research into their properties and possible applications. This book provides a comprehensive and up-to-date survey of the research areas of carbon nanotubes, inorganic nanotubes and nanowires including: synthesis; characterisation; properties; applications. This fully revised and updated edition includes an extensive list of references and is ideal both for graduates needing an introduction to the field of nanomaterials as well as for professionals and researchers in academia and industry.

Buch. Zustand: Neu. Neuware - Petroleum-based fuels are well-established products that have served industry and consumers for more than one hundred years. However petroleum, once considered inexhaustible, is now being depleted at a rapid rate. As the amount of available petroleum decreases, the need for alternative technologies to produce liquid fuels that could potentially help prolong the liquid fuels culture and mitigate the forthcoming effects of the shortage of transportation fuels is being sought. The dynamics are now coming into place for the establishment of a synthetic fuels industry; the processes for recovery of raw materials and processing options have to change to increase the efficiency of oil production and it is up to various levels of government not only to promote the establishment of such an industry but to recognise the need for available and variable technology. This timely handbook is written to assist the reader in understanding the options that available for the production of synthetic fuel from biological sources. Each chapter contains tables of the chemical and physical properties of the fuels and fuel sources. It is essential that the properties of such materials be presented in order to assist the researcher to understand the nature of the feedstocks as well as the nature of the products. If a product cannot be employed for its hope-for-use, it is not a desirable product and must be changed accordingly. Such plans can only be made when the properties of the original product are understood. The fuels considered include conventional and unconventional fuel sources; the production and properties of fuels from biomass, crops, wood, domestic and industrial waste and landfill gas.