rsc publishing feb 2015 (3 Ergebnisse)

Buch. Zustand: Neu. Neuware - The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.

Buch. Zustand: Neu. Neuware - The efficient synthesis of heterocycles has become one of the main branches in organic chemistry due to their use in the synthesis of natural products and pharmaceuticals. Current sythentic strategies based on C-H activation methodologies are met with many problems like harsh reaction conditions and low reaction efficiency. Double functionalized chemicals offer a perfect alternative for the synthesis of heterocycles.

Buch. Zustand: Neu. Neuware - This Faraday Discussion focuses on one very fundamental issue of nanoparticle (NP) research: functionalisation specifically related to biomedical applications. Without the right functionalisation, NPs will be rendered useless, therefore how can NPs be synthesised with the desired functionality Nanotechnology, especially nanoparticle research, has played a very important role in many scientific discoveries, laying the foundation for its application in many aspects of our lives, such as healthcare, efficient energy and cleaner environments. The field is moving very quickly, with an ever-increasing number of researchers.This volume will promote deep discussion on a topic that has previously been neglected. The whole field would stand still without the availability of appropriate functionalisations for specific applications. The latest research and discussion presented here on this very important issue will help to harness the full potential of nanoparticle research.Topics covered in this volume include:. Noble metal NPs: novel syntheses of noble metal NPs and better understanding of their surface chemistry and the interactions between these NPs and ligands.