rsc publishing apr 2006 (6 Ergebnisse)

Buch. Zustand: Neu. Neuware - New techniques, improvements in understanding and changes in regulations relating to environmental analysis mean that students, technicians and lecturers alike need an up-to-date guide to practical environmental analysis. This unique book provides detailed instructions for practical experiments in environmental analysis. The comprehensive coverage includes the chemical analysis of important pollutants in air, water, soil and plant tissue, with experiments generally requiring only basic laboratory equipment and instrumentation. The principles behind each method are explained and the importance of various pollutants in the environment is discussed. Also included are suggestions for projects and worked examples, and appendices cover environmental standards, practical safety and good laboratory practice. Building on the foundations laid by the highly-acclaimed first edition, this revised and updated new edition is certain to be valued as an indispensable guide to practical environmental analysis by students and lecturers from a wide range of scientific disciplines. TOC:Introduction.- Rainwater Analysis.- Air Analysis.- Water Analysis.- Soil, Sludge Sediment and Dust Analysis.- Plant Analysis.- Appendices.

Buch. Zustand: Neu. Neuware - Contamination of water supplies and the immediate availability of appropriate emergency responses to chemical, biological, radiological or nuclear (CBRN) events which result in contaminated water are becoming increasingly relevant and significant issues in the water industry and in the wider world. Consequently, new strategies and technologies are being constantly evolved and refined by leading experts in the field in order to achieve rapid and effective responses to water contamination events.Water Contamination Emergencies: Enhancing our Response brings together contributions from leading scientists and experts from both academia and industry in the field of water contamination and emergency planning. The book covers a wide range of topics including responses to water contamination emergencies, impacts on public health and commerce, risk assessment, analysis and monitoring, emergency planning, control and planning and threats to the water industry.This book is ideal for specialists in the field of water contamination and emergency response planning, especially researchers and professionals in industry and government who require an authoritative and highly specialised resource on water contamination management. The reader will gain an appreciation of the activities supporting the development of responses to contamination events; emergency actions required in response to the contamination of drinking water; and incident management. Also discussed are the importance of communication between organisations and the public; consumer perceptions and the need for robust and rapid screening of samples to help answer the key question 'Is this water safe to drink '.

Buch. Zustand: Neu. Neuware - Structure-Based Drug Discovery is a collection of methods which exploit the ability to determine and analyse the three-dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of drug discovery.After an introductory overview of the principles and applications of structure-based methods in drug discovery, the essential features of the various methods are explored. Chapters on X-ray crystallography, NMR spectroscopy, computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high-throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening, and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories which demonstrate the major impact that structure-based methods have had on the drug discovery process.Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides useful scientific background for the non-expert reader. The book presents a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences. TOC:3D Structure and the Drug Discovery Process.- Structure Determination: Crystallography for Structure-based Drug Design.- Molecular Modelling.- Applications of NMR in Structure-based Drug Design.- Fragment Screening: An Introduction.- Iterative Structure-based Screening of Virtual Chemical Libraries and Factor Xa: Finding the Orally-Available Antithrombotic Candidate LY517717.- Anti-Influenza Drugs from Sialidase Inhibitors.- Isoform Specificity: The Design of Estrogen Receptor-Selective Compounds.

Buch. Zustand: Neu. Neuware - Trace element analysis has a key role to play in quality control of food and diet. This timely book introduces the subject in a practical way - from sampling and the techniques available for trace analysis, to procedures for specific elements and data analysis.Beginning with a brief introduction and discussion of statistical evaluation of data, the subsequent chapter looks at trace analysis in general, with its essentials and terminology. Another section introduces sampling and preparation of foodstuffs such as wheat, potato, vegetables and milk. This is followed by descriptions of the various spectrometric techniques (atomic absorption, atomic emission, atomic fluorescence) that are available. Plasma techniques for both optical emission and mass spectrometry are presented, as are nuclear activation analysis and X-ray methods. A comparison of the various analytical techniques is provided, and a separate chapter handles speciation analysis. Finally, procedures for determining essential and toxic elements such as arsenic, iron, selenium and zinc are suggested, using several recent references.Detailed explanations and a simple format will appeal to laboratory technicians and graduate students, as well as more experienced researchers. Comprehensive coverage, coupled with illustrations and a guide to relevant literature and manufacturers, will make Trace Element Analysis of Food and Diet a valuable source of information for anyone working on analysis of trace elements in food, diet or other biological or environmental samples - particularly food engineers, agricultural scientists and government testing agency employees. TOC:Introduction.- Trace Analysis.- Sampling and Sample Pretreatment.- Spectrochemistry for Trace Analysis,- Atomic Absorption Spectrometry.- Atomic Emission and Mass Spectrometry using Plasma Techniques.- Atomic Fluorescence Spectrometry.- Nuclear Activation Analysis.- X-Ray Methods.- Speciation Analysis, Comparison of Analytical Techniques.- Essentiality and Toxicity of some Trace Elements and their Determination.

Buch. Zustand: Neu. Neuware - Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own innovative processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry, while illustrating the basic approaches currently being used to effect receptor design.The combination of a biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally-occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry.Providing a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of this exciting research area. Fully-referenced and illustrated in colour, it is a welcome addition to the literature. TOC:Preface.- Introduction.- Classic Charged Non-Metallic Systems.- Protonated Expanded Porphyrins and Linear Analogues.- Neutral Non-Metallic Systems.- Neutral Pyrrole Systems.- Receptors for Ion Pairs.- Metal and Lewis Acid Based Receptors.- Sensors.- Anion Controlled Assembly and Template-based Synthesis.- Afterword.

Buch. Zustand: Neu. Neuware - Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays, this book provides a comprehensive overview of modern approaches to lead identification.Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines, will value the comprehensive and up-to-date coverage. TOC:Operational Developments in Chemistry: The Use of Polymer-assisted Solution-phase Synthesis and Automation for the High-throughput Preparation of Biologically Active Compounds.- Accelerated Chemistry: Microwave, Sonochemical, and Fluorous Phase Techniques.- Conceptual Advances in Synthesis Prospecting: Design of Discovery Libraries and the Search for Hits: Biosynthesis of 'Unnatural' Natural Products.- Combinatorial Synthetic Design: the Balance of Novelty and Familiarity.- Compound Collections: Acquisition, Annotation, and Access.- Chemical Diversity: Definition and Quantification.- Conceptual Advances in Synthesis Mining: Turning a Hit into a Lead: Focused Libraries: the Evolution in Strategy from Large Diversity Libraries to the Focused Library Approach.- Translating Peptides into Small Molecules.- Operational Developments in Screening and High Throughput Assays: High Density Plates, Microarrays, Microfluidics.- Fluorescence Technologies for the Investigation of Chemical Libraries.- The Use of Genetically Engineered Cell-based Assays in in-vitro Drug Discovery.- NMR Based Screening, a Powerful Tool in Fragment-based Drug Discovery.- Screening Chemical Microarrays: Methods and Applications.- Conceptual Advances in Lead Evaluation: Screen Early and Often: Screen/Counter-screen: Early Assessment of Selectivity.- Concepts for in-vitro Profiling - Drug Activity, Selectivity and Liability.- In silico Surrogates for in vivo Properties: Profiling for ADME and Toxicological Behavior.- Use of High Content Screening in Chemical Optimization.- Subject Index.