Mdpi ag aug 2017 (2 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - In recent years, studies in the field of thyroid cancer have been performed in order to identify and verify thyroid specific biomarkers, as well as cancer-specific changes in gene expression patterns and alterations of the protein content. Furthermore, new drugs, small molecules and antibodies were developed and tested in vitro and in vivo. Trials investigated the ratio between therapeutic and adverse effects. Tyrosine kinase inhibitors (TKI) have become a new therapeutic option of both differentiated thyroid cancer and medullary thyroid cancer. In the last few years, new substances for targeted systemic therapy have been approved after their efficacy was demonstrated in Phase III trials. Most of them show a moderate response. However, adverse effects are common. TKI are used in patients with advanced metastatic thyroid cancer that is radioiodine (RAI)-refractory.In this Special Issue, original studies on the pathophysiology, diagnosis, and therapy of thyroid cancer, including genetics, proteomics, metabolomics, molecular and cell biology, will be published. It will also cover reports on patients, providing novel mechanistic insights into the underlying pathogenesis or new aspects that may impact clinical therapy, and recent study results in order to review the current status of new therapy options in thyroid cancer. …

Taschenbuch. Zustand: Neu. Neuware - Pig production is the fastest growing segment of the global livestock sector. Intensification of pig production has resulted in significant changes to traditional pig husbandry practices. Combined with urbanization and ease of travel and transport, these changes have led to an environment conducive to increased emergence and spread of viral diseases. The past decade alone has seen the global emergence and re-emergence of porcine viruses with devastating consequences: For example, in 2006, highly pathogenic porcine reproductive and respiratory syndrome viruses (PRRSV) spread rapidly across Southeast Asia killing millions of animals; since its introduction into the Caucasus in 2007, the African swine fever virus has steadily spread to Eastern Europe; and in 2013-14, over 8 million pigs died when virulent porcine epidemic diarrhea virus (PEDV) swept North America. In this special issue we will explore our understanding of porcine viruses and how this may be exploited to improve the control of these pathogens of economic and agricultural significance.…