Epfl press jul 2016 (2 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - Lipidomics forms part of the field of metabolomics, which in turn follows on from genomics, transcriptomics, and proteomics, in a top-down manner. It is the study of hydrophobic molecules called lipids; however, lipid molecular species are so numerous that investigators tend to subdivide global lipidomics into targeted lipidomic approaches.This book focuses on structural and mediator lipidomics, with a particular emphasis on their functional aspects. This includes lipids deserving of special interest for their structures (especially as parts of cell membranes or plasma lipoprotein particles) and lipids known for their biological activities, which mediate the action of cell agonists (for example, hormones, growth factors, etc.). The oxygenated metabolites of the major functional w6 and w3 polyunsaturated fatty acids in mammals, in particular arachidonic and docosahexaenoic acids, are presented, with special attention paid to their structure-function relationships. These metabolites are very active, and their biological relevance was recognized early on with a Nobel Prize in Physiology and Medicine in 1982. Finally, general principles for the high performance analysis and characterization of lipid species are also presented. The book has been written for undergraduate students and scientists interested in the field of lipids. Clinicians will also be able to find useful information, due to the numerous references to pathophysiology.…

Taschenbuch. Zustand: Neu. Neuware - Integrated transport and land use models are an increasingly used tool for evaluation of urban policy and large scale projects. Although there is a well-built theoretical background supporting the existing models, there are few exhaustive descriptions of the methodological implications and implementation efforts behind these tools.This handbook describes the modeling effort, methodological contributions, and results of the SustainCity project. SustainCity, financed by the European Union, implemented integrated microsimulation models for European cities, generating a quantitative tool for policy evaluation, specially focused on sustainability issues. The book describes the implementation of an improved, UrbanSim-based platform for three European cities: Brussels, Paris, and Zurich. The analysis is focused on the methodological contributions that resulted from the modeling effort and the practical aspects of microsimulation models as policy evaluation tools.…