Elsevier bv okt 1997 (4 Ergebnisse)

Buch. Zustand: Neu. Neuware - Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.…

Buch. Zustand: Neu. Neuware - Lipobiology is a rapidly evolving interdisciplinary field which incorporates critical aspects of lipid and lipoprotein chemistry into the disciplines of cell biology and physiology. This series focuses on salient aspects of the role of lipids in metabolic regulation and cellular activation.…

Buch. Zustand: Neu. Neuware - This is the fourth volume in the series, aimed at those wishing to stay abreast of developments in the mechanisms and synthetic applications of 1,3-dipolar cycloaddition reactions.

Buch. Zustand: Neu. Neuware - In the last two decades, the field of time-frequency analysis has evolved into a widely recognized and applied discipline of signal processing. Besides linear time-frequency representations such as the short-time Fourier transform, the Gabor transform, and the wavelet transform, an important contribution to this development has undoubtedly been the Wigner distribution (WD) which holds an exceptional position within the field of bilinear/quadratic time-frequency representations.The WD was first defined in quantum mechanics as early as 1932 by the later Nobel laureate E. Wigner. In 1948, J. Ville introduced this concept in signal analysis. Based on investigations of its mathematical structure and properties by N.G. de Bruijn in 1967, the WD was brought to the attention of a larger signal processing community in 1980. The WD was soon recognized to be important for two reasons: firstly, it provides a powerful theoretical basis for quadratic time-frequency analysis; secondly, its discrete-time form (supplemented by suitable windowing and smoothing) is an eminently practical signal analysis tool.The seven chapters of this book cover a wide range of different aspects of the WD and other linear time-frequency distributions: properties such as positivity, spread, and interference term geometry; signal synthesis methods and their application to signal design, time-frequency filtering, and signal separation; WD based analysis of nonstationary random processes; singular value decompositions and their application to WD based detection and classification; and optical applications of the WD. The size of the chapters has been chosen such that an in-depth treatment of the various topics is achieved.…