Elsevier bv jan 2000 (3 Ergebnisse)
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EUR 121,28
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Buch. Zustand: Neu. Neuware - Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, str…oke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.
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EUR 288,16
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Buch. Zustand: Neu. Neuware - The International Conference on Mechanical Design and Production has over the years established itself as an excellent forum for the exchange of ideas in these established fields. The first of these conferences was held in 1979. The seventh, and most recent, conference in the series was held in Cair…o during February 15-17, 2000. International engineers and scientists gathered to exchange experiences and highlight the state-of-the-art research in the fields of mechanical design and production. In addition a heavy emphasis was placed on the issue of technology transfer. Over 100 papers were accepted for presentation at the conference. Current Advances in Mechanical Design & Production VII does not, however, attempt to publish the complete work presented but instead offers a sample that represents the quality and breadth of both the work and the conference. Ten invited papers and 54 ordinary papers have been selected for inclusion in these proceedings. They cover a range of basic and applied topics that can be classified into six main categories: System Dynamics, Solid Mechanics, Material Science, Manufacturing Processes, Design and Tribology, and Industrial Engineering and its Applications.
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EUR 341,11
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Buch. Zustand: Neu. Neuware - This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease ar…e especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.
