Crc press dez 2021 (6 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I-II Clinical Trials describes how phase I-II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.…

Taschenbuch. Zustand: Neu. Neuware - Pharmaceutical product development is a multidisciplinary activity involving extensive efforts in systematic product development and optimization in compliance with regulatory authorities to ensure the quality, efficacy and safety of resulting products.Pharmaceutical Product Development equips the pharmaceutical formulation scientist with extensive and up-to-date knowledge of drug product development and covers all steps from the beginning of product conception to the final packaged form that enters the market and lifecycle management thereof.Applications of core scientific principles for product development are also thoroughly discussed in conjunction with the latest approaches involving design of experiment and quality by design with comprehensive illustrations based on practical case studies of several dosage forms.The book presents pharmaceutical product development information in an easy-to-read mode with simplified theories, case studies and guidelines for students, academicians and professionals in the pharmaceutical industry. It is an invaluable resource and hands-on guide covering managerial, regulatory and practical aspects of pharmaceutical product lifecycle management.…

Taschenbuch. Zustand: Neu. Neuware - Atlas of Terrestrial Mammal Limbs is the first comprehensive and detailed anatomy book on a broad phylogenetic and ecological range of mammals. This extraordinary new work features more than 400 photographs and illustrations visualizing the limb musculature of 28 different species. Standardized views of the dissected bodies and concise text descriptions make it easy to compare the anatomy across different taxa. It provides tables of nomenclature and comparative muscle maps (schematic drawings on the origins and insertions of the muscles onto bones) in a diversity of animals. Atlas of Terrestrial Mammal Limbs is a reliable reference and an indispensable volume for all students and professional researchers in biology, paleontology, and veterinary medicine.Key Features: - Provides an overview of the anatomy of the mammalian limb - Includes osteological correlates of the limb muscles - Illustrates anatomy in 2D - Guides dissection - Documents anatomical diversity in mammalian limbs Related Titles:D. L. France. Human and Nonhuman Bone Identification: A Color Atlas. (ISBN 978-1-4200-6286-1)S. N. Byers. Forensic Anthropology Laboratory Manual, 4th Edition (ISBN 978-1-1386-9073-8)S. N. Byers. Introduction to Forensic Anthropology, 5th Edition (ISBN 978-1-1381-8884-6)R. Diogo, et al. Muscles of Chordates: Development, Homologies, and Evolution (ISBN 978-1-1385-7116-7).…

Taschenbuch. Zustand: Neu. Neuware - The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified-natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics.Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: - Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, - The tremendous potentiality of metabolic engineering of natural products biosynthesis - The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism - The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity - Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.…

Taschenbuch. Zustand: Neu. Neuware - To succeed in the lab, it is crucial to be comfortable with the math calculations that are part of everyday work. This accessible introduction to common laboratory techniques focuses on the basics, helping even readers with good math skills to practice the most frequently encountered types of problems. Basic Laboratory Calculations for Biotechnology, Second Edition discusses very common laboratory problems, all applied to real situations. It explores multiple strategies for solving problems for a better understanding of the underlying math. Primarily organized around laboratory applications, the book begins with more general topics and moves into more specific biotechnology laboratory techniques at the end. This book features hundreds of practice problems, all with solutions and many with boxed, complete explanations; plus hundreds of 'story problems' relating to real situations in the lab. Additional features include: - Discusses common laboratory problems with all material applied to real situations - Presents multiple strategies for solving problems help students to better understand the underlying math - Provides hundreds of practice problems and their solutions - Enables students to complete the material in a self-paced course structure with little teacher assistance - Includes hundreds of 'story problems'that relate to real situations encountered in the laboratory.…

Taschenbuch. Zustand: Neu. Neuware - Cutaneous Cryosurgery is an invaluable practical guide for the management of benign, premalignant, and malignant skin lesions. The book provides practitioners with all the information needed to add cryosurgery to their surgical repertoire. For practitioners already using cryosurgery, many pearls are provided to expand the use of cryosurgery for new indications along with helpful tips for the use of cutting-edge cryosurgical equipment.This new edition of an established reference uses an evidence-based approach, including a chapter reviewing the evidence for using cryosurgery to treat viral warts, actinic keratosis, and basal cell carcinoma. It also discusses patient consent, aftercare, side effects, and complications. In addition, the book reviews other low-temperature systems used for therapeutic tissue destruction.With nearly 300 clinical color photographs, the book is an outstanding resource for dermatologists, family physicians, other primary care physicians, nurse practitioners, physician assistants, podiatrists, plastic surgeons, head and neck surgeons, and oculoplastic surgeons alike.…