Cold spring harbor laboratory press aug 2012 (3 Ergebnisse)

Buch. Zustand: Neu. Neuware - Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture. …

Buch. Zustand: Neu. Neuware - First described as 'the shaking palsy' in 1817 by James Parkinson, Parkinson's disease is a disabling neurodegenerative disorder that is common among the elderly. It involves the gradual depletion of brain cells that control balance and movement, causing trembling, muscle rigidity, and difficulty walking. Characteristic brain changes -- such as the formation of Lewy bodies and the degeneration of dopamine-producing neurons -- have been identified, but diagnostic tests and therapeutic options remain limited. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Parkinson's disease, from its neuropathological and clinical bases to the diagnostic challenges and therapeutic interventions. Contributors discuss the mutations in genes encoding proteins such as synuclein, parkin, and LRRK2 that cause Parkinson's disease; the roles of mitochondria, autophagy, protein quality control, and programmed cell death in disease progression; and the chemistry and anatomy of the basal ganglia that are affected. The use of functional neuroimaging and experimental models to probe the neurobiology of Parkinson's disease are also described. Blending both the clinical and basic science of Parkinson's disease, this volume is a vital reference for neurobiologists, cell biologists, and pathologists pursuing the biological basis of Parkinson's disease, as well as scientists and clinicians interested in its diagnosis and treatment. …

Buch. Zustand: Neu. Neuware - The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including 'ribosomopathies.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.…