Capricorn publishing (32 Ergebnisse)

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Taschenbuch. Zustand: Neu. Neuware - Elizabeth Wilson believed the greatest risk she had ever taken was leaving England behind and marrying Alexander Mackintosh, the Highlander who offered her freedom when she had almost lost hope.But beginning a new life in the Scottish Highlands brings challenges neither of them expected.As Elizabeth settles into the warmth and chaos of the Mackintosh family, she discovers a world far removed from the life she once knew. Surrounded by unfamiliar customs, new friendships, and the rugged beauty of the Highlands, she begins to understand what it truly means to belong.Yet the past has not finished with them.Danger still follows Alex and Elizabeth, and when their journey becomes entwined with that of a young boy who has known far too little kindness, the choices they make will change more than one life forever.Through danger, loss, laughter, and love, Alex and Elizabeth must learn that building a home is about more than finding a place to live. It is about the people they choose to bring into it.Set against the dramatic landscape of seventeenth-century Scotland, The House of Mackintosh is a story of family, resilience, romance, and finding home where you least expected it.The second book in The Rosethorne and Highlands Saga.…

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Soft Cover. First Edition. 4to. original printed paper wraps (a trifle rubbed); pp. viii (last blank), 72, with illustrations. A fine copy.

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Zustand: New. pp. 358.

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Taschenbuch. Zustand: Neu. Neuware - There were studied the characteristics of spontaneous and induced chromatin restructuring of neutrophilic granulocytes of peripheral blood in healthy people and patients with various diseases. It was found that the levels of the restructurization of nucleus chromatin of neutrophilic granulocytes were differ in healthy people and in patients with different variants of pathologies. The levels of the restructurization of nucleus chromatin of neutrophilic granulocytes were associated with the nature and severity of the disease process. So in duodenal ulcer complicated by stenosis, there was a pronounced of the restructurization of nucleus chromatin of neutrophilic granulocytes. In patients with rheumatoid arthritis the levels of the restructurization of the nucleus chromatin of neutrophilic granulocytes indicated significant hyperactivation of neutrophilic granulocytes of peripheral blood and of synovial fluid. It was also found that the neutrophilic granulocytes of purulent discharge in patients with the acute phlegmon of the maxillofacial region were exhibited the high levels of the restructurization of nucleus chromatin, which were decreased in according with the positive changing of reparative processes in the wound. In acute destructive pancreatitis and in leptospirosis the levels of the restructurization of chromatin of neutrophilic granulocytes were also very high, but in the cases of the very severe acute destructive pancreatitis and leptospirosis the restructurization of the chromatin of neutrophilic granulocytes were decreased. In neoplastic diseases such as colorectal cancer and were the contrary in respect to each other. So in chronic myelogenous leukemia the levels of the restructurization of nucleus chromatin of neutrophilic granulocytes were very high and in colorectal cancer it was observed decreasing neutrophilic granulocytes and its total blockage of response after induction.Thus, developed new approaches to the assessment of the functioning of the neutrophilic granulocytes using the new methods of testing the restructurization of nucleus chromatin of neutrophilic granulocytes in healthy people and in patients with different variants of pathologies. These data can be used in the future as diagnostic and prognostic criteria in the assessment of the functioning of the neutrophilic granulocytes in healthy individuals and different diseases.…

Zustand: New. pp. 368.

Taschenbuch. Zustand: Neu. Neuware - In recent decades, the interest of researchers to study the amazing cells of the immune system of neutrophilic granulocytes (NG) has increased significantly worldwide. Modern research convincingly shows that NG are not just quick reaction cells - 'professional killers' that destroy aggressive bacteria, viruses, fungi, but also key effector and regulatory cells, both innate and adaptive immunity, through various mechanisms, and, at the same time, play a crucial role in immunopathogenesis of a wide range of diseases, both infectious and inflammatory, and autoimmune, allergic and oncological. The team of authors of this book is engaged in the study of various aspects of NG functioning, both in norm and in various pathological conditions for more than 30 years. The monograph presents a modern analysis of scientific data obtained by both domestic and foreign researchers. In addition, we describe the most interesting, from our point of view, studies conducted by our team during the last decade. They are devoted to the detection of various subpopulations of NG, changes in their phenotype and functional activity in various atypically infectious and inflammatory diseases, both in children and in adult patients, and in oncopathology, - colorectal cancer, in adult patients. At the same time, both diagnostic and prognostic significance of the detection of various subpopulations of NG and the transformation of their phenotype was demonstrated. Peculiarities of the NG phenotype and their functional properties demonstrate the presence of NG subpopulations with different possibilities: different receptor equipment, ability to restructure chromatin, express cytokine genes and secrete cytokines, realize the contents of the granular apparatus, produce active forms of oxygen, perform cytotoxicity, form NET. A modern classification of NG subpopulations is given. NG dysfunction: quantitative or functional defects, lack of adequate response - blockade of functions lead to the development of sluggish, not responding to traditional therapy of acute or chronic infectious and inflammatory diseases, hyperactivation of NG occurs in autoimmune diseases and other immunodeficient processes. Remodeling of NG dysfunctions is the key to new immunotherapeutic strategies. We believe that the monograph will be of interest not only to clinical immunologists and allergologists, but also infectious disease specialists, pediatricians, therapists, otolaryngologists, researchers, teachers, graduate students, students of medical universities and university biological faculties.…