Caister academic press (584 Ergebnisse)

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1000grams, ISBN:9781904455509. …

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. Clean from markings. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1700grams, ISBN:9781904455004. …

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1400grams, ISBN:9781904455028.

Hardcover. Zustand: Fine. First Edition. Ding to front board bottom, else virtually As New condition, inside and out. Glossy pictorial cloth over boards. Contributions by the editor John T. Patton and by Hong Zhou, Polly Roy, Matthew L. Baker, Z. Hong Zhou and Wah Chiu, Jose R. Caston, Jose F. Rodriguez and Jose L. Carrascosa, Leslie A. Schiff, Philip R. Dormitzer, Leonard Minditch and many others. From the publisher's blurb, "The double-stranded (ds)RNA viruses represent a diverse group of viruses that vary widely in host range (humans, animals, plants, fungi, and bacteria), genome segment number (one to twelve), and virion organization (T-number, capsid layers, or turrets). Members of this fascinating group include the rotaviruses, renowned globally as the commonest cause of gastroenteritis in young children, and bluetongue virus, an economically important pathogen of cattle and sheep. In recent years, remarkable progress has been made in determining, at atomic and subnanometeric levels, the structures of a number of key viral proteins and of the virion capsids of several dsRNA viruses, highlighting the significant parallels in the structure and replicative processes of many of these viruses. By providing unique insights into fundamental aspects of structure-function relationships in virus particles, virus particle assembly, virus-cell interactions, and viral pathogenesis, approaches for the development of novel antiviral strategies and/or agents can be designed. This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase lambda; assembly of the retrovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x [2], 4-373 pp. plus then a long range of full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Paperback. Zustand: Good. No Jacket. Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less.

Zustand: Fair. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,900grams, ISBN:9781904455240.…

Zustand: New. In.

Zustand: Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition, suitable as a reading copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1050grams, ISBN:9781904455219.…

Zustand: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. Clean from markings. In good all round condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,950grams, ISBN:9781904455790. …

Zustand: New. In.

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear, bright and shiny pictorial covers in purple and white. Edited by James W.B. Moir and with contributions by him and by David Richardson, Jrg Simon, Marc Strous, Stephen Spiro, Shilpa Ball and Stuart J Ferguson, John W. Peters, Eric S. Boyd, Trinity Hamilton and Luis M. Rubio and many others. From a portion of the publisher's blurb, "This timely book aims to provide comprehensive reviews of current nitrogen cycle research and to give a broader perspective on the state of our understanding of this key biogeochemical cycle. With contributions from expert authors from around the world, topics covered include: the archaean N-cycle; redox complexes N-cycle; organisation of respiratory chains in N-cycle processes; Mo-nitrogenase; nitrogen assimilation in bacteria; alternative routes to dinitrogen; nitrite and nitrous oxide reductases; assembly of respiratory proteins; nitric oxide metabolism; denitrification in legume-associated endosymbiotic bacteria; nitrous oxide production in the terrestrial environment; bacterial nitrogen cycling in humans. This book will serve as a valuable reference work for everyone working in this field and will also be of interest to researchers studying symbioses, environmental microbiology, plant metabolism, infection events and other prokaryote-eukaryote interactions." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. vii [2], 2-250 pp. and with many black-and-white illustrations and photographs.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear, bright and shiny pictorial covers, illustrated. Apparently unread, spine still crackles. From the publisher's blurb, "Bacteria have evolved extraordinary abilities to regulate aspects of their behaviour (such as gene expression) in response to signals in the intracellular and extracellular environment. Key to this are the diverse macromolecules (proteins or RNA) that sense change through direct interactions with chemical or physical stimuli. In recent years there have been tremendous advances in our understanding of the structure and function of these signal receptors, and of how interaction with the signal triggers changes in their activity and downstream events. For some systems this understanding extends to the atomic level. In this unique book, an international team of experts reviews a selection of important model systems, providing a timely snapshot of the current state of research in the field. The book opens with an introductory chapter that reviews the diversity of signal recognition mechanisms, illustrating the breadth of the field. Subsequent chapters include descriptions of the sensing of ligands (?-ketoglutarate, adenylate energy charge, glutamine and xenobiotic compounds), chemoreceptors, iron-sulfur cluster-based sensors, metal-dependent and metal-responsive sensors, thiol-based sensors, and PDZ domains as sensors of other proteins. This book provides essential reading for everyone with an interest in sensory mechanisms, regulatory networks and responses to environmental stress in bacteria." Contributions from L. Aravind, Lakshminarayan M. Iyer and Vivek Anantharaman; H. Kneuper, P. Scheu, M. Etzkorn, M. Sevvana, P. Dünnwald, S. Becker, M. Baldus, C. Griesinger, and G. Unden; Alexander J. Ninfa and Peng Jiang; Víctor de Lorenzo, Rafael Silva-Rocha, Guillermo Carbajosa, Teca C. Galvão and Ildefonso Cases; Michael D. Manson; Jeffrey Green, Jason C. Crack, Adrian J. Jervis, David P. Dibden, Laura J. Smith, Andrew J. Thomson and Nick E. Le Brun; John D. Helmann; Haike Antelmann and Peter Zuber; Rebecca Kirk and Tim Clausen. vii [3], 2-267 pp. including notes, bibliography and index, followed by a range of full-color plates.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

hardcover. Zustand: Like New. Most items will be dispatched the same or the next working day. An apparently unread copy in perfect condition. Dust cover is intact with no nicks or tears. Spine has no signs of creasing. Pages are clean and not marred by notes or folds of any kind.

Hardcover. Zustand: As New. First Edition. Genome Analysis is a fine, then definitive survey of current procedures and applications, edited by Maria S. Poptsova and with contributions by her and by Suzanne S. Sindi and Benjamin J. Raphael, Paul Zumbo and Christopher E. Mason, Thomas J. Hardcastle, Ivan V. Kulakovskiy and Vsevolod J. Makeev, Dongwon Lee and Michael A. Beer, Ilya Ioshilkhens, Marta Sanchez-Carbayo, Laurent Modolo and Emmanuelle Lerat, Pieter De Maayer, Angel Valverde and Dona A. Cowan, Atsushi Ogura, James W.J. Anderson and several others. Fine-looking, structurally sound hardcover, little discernible wear to the glossy pictorial cloth over boards, bright interior, unmarked.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Hardcover. Zustand: Fine. First Edition. Fine-looking, structurally sound hardcover, little discernible wear to the glossy pictorial cloth over boards beyond a ding to front panel bottom near spine, bright interior, unmarked. Stated First Edition, First Printing, with "1" or "a" in "number" line present. Contributions by the editor, Diana Marco, and by Dominic W.S. Wong, Karen E. Nelson and Bryan A. White, and many others. Hundreds of charts, tables, illustrations and photographs. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. ix [3], 2-212 pp. plus a range of full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Fine-looking, structurally sound hardcover, little discernible wear to the glossy pictorial cloth over boards, bright interior, unmarked. Contributions by the editor, Diana Marco, and by Robert L. Dorit and Margaret A. Riley, Liping Zhao and Jian Shen, Vincent Montoy, Charles Y. Chiu and Patrick Tang, and many others. Hundreds of charts, tables, illustrations and photographs. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. 291 pp. plus a range of full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny dust jacket, protected. Contributions by the editor, Pei-Yong Shi, and by Duane J. Gubler, Richard J. Kuhn, Scott B. Halstead, and many other acknowledged experts in the field of virology and flaviviruses. Dozens of tables, graphs, illustrations. From the publisher's blurb, "Flaviviruses are a diverse group of small RNA enveloped viruses, many of which are important human and animal pathogens. The best known include dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. These viruses are endemic in many tropical and sub-tropical regions of the world. Dengue virus alone infects over 100 million people annually. In recent years, research on flaviviruses has progressed at a remarkable rate, leading to significant advances in our understanding of virus biology. This should ultimately lead to the development of better vaccine and antiviral strategies. This up-to-date and cutting-edge anthology contains contributions from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators who have dedicated their careers to flavivirus research with those from newcomers who have recently made significant contributions to the flavivirus field. The book is divided into two sections: Molecular Virology and Virus Prevention. The first section on Molecular Virology covers: virion structure * virus replication * the NS1 glycoprotein * the NS3 protein * the NS5 protein * innate immunity and flavivirus infection * host responses to flavivirus infection * flavivirus fitness and transmission. The Virus Prevention section includes: vaccines * antibody therapy * small molecule antiviral development * flavivirus diagnostics * vector-virus interactions * vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. It is a recommended text for all virology libraries." [11], 12-358 pp., followed by a range of full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear, bright and shiny interior, clean and unmarked. Glossy pictorial cloth over boards. Augmented with many score illustrations and photographs, in 14 chapters, contributions by the two editors, Ralf G. Dietzgen and Ivan V. Kuzmin, and by Luis L. Rodriguez and Steven J. Pauszek, Ivan V. Kuzmain and Noel Tordo, Gael Kurath, Peter J. Walker, Kim R. Blasdell and D. Albert Jourbert, Aneta Gubala, and many others. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. [11], 2-276 pp. then followed by a range of full-page, full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Fine-looking, structurally sound hardcover, little discernible wear to the glossy pictorial cloth over boards, bright interior, unmarked. Contributions by the editor, Kevin V. Morris, and by Harris Soiter, Isidore Rigoutsos, Yoichi R. Fujii and Nitin K. Saksena, Lena J. Chin and Frank J. Slack and many others. From the publisher's blurb, "The role of RNA in regulating gene expression has become a topic of intense interest. In this book, internationally recognized experts in RNA research explore and discuss the methods whereby RNA can regulate gene expression with examples in yeast, Drosophila, mammals, and viral infection, as well as highlight the application of this knowledge in therapeutics and research. Topics include: gene silencing and gene activation, the hammerhead ribozyme, epigenetic regulation, RNAi, microRNA, and pyknons. This comprehensive publication is intended for readers with teaching or research interests in RNA, the regulation of gene expression, genetics, genomics, and molecular biology." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. vii [3], 4-228 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Asgari, Sassan and Karyn Johnson, and with contributions by the editors and by two dozen acknowledged experts in the field. From the publisher's blurb, "Fuelled by the application of omics and reverse genetics technologies, impressive progress has been achieved in the field of molecular and cellular biology of Bunyaviridae in recent years. In this book, a panel of international experts review the most important findings, providing a timely and coherent overview of the field. All five genera i.e. Orthobunyavirus, Hantavirus, Nairovirus, Plebovirus and Tospovirus, are covered in seperate chapters. Genetics and evolution of hantaviruses is given a special treatment in chapter 3 while current advances in diagnostics are reviewed in detail in chapter 7. The book closes with an excellent overview of the remaining challenges and future prospects in this fascinating field. The book is essential reading for everyone working on bunyaviruses and related viruses. A recommended text for all virology libraries." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x [1], 2-435 pp., followed by a long range of full-color plates, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Zhaomin Yang and Penelope I. Higgs, and with contributions by the editors and by two dozen acknowledged experts in the field. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. xi [1], 2-235 pp. and with a range of full-color plates following, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Reid, Christopher W., Susan M. Twine and Anne N. Reid, and with contributions by the editors and by two dozen acknowledged experts in the field. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x [1], 2-270 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x [1], 2-436 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Baltasar Mayo and Douwe van Sinderen, and with contributions by the editors and by two dozen acknowledged experts in the field. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. xii [1], 2-259 pp. and with a range of full-color plates following, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Siba K. Samal, and with contributions by the editor and by two dozen acknowledged experts in the field. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. vii [2], 2-409 pp. and with a range of full-color plates following, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards. Apparently unread, spine still crackles. From the publisher's blurb, "Microbial biodegradation of non-metals pollutants plays a pivotal role in the bioremediation of contaminated soil and groundwater sites. Such pollutants include chloroethenes, steroids, organophosphorus compounds, alkanes, PAHs and PCBs. In this important new book, expert international authors exhaustively review this topic from a biochemical and genetic viewpoint, providing a timely overview of current research. Topics covered include: enzymatic biodegradation reactions; the impact of bioturbation on hydrocarbon dynamics in marine sediments; the structure, function and biodiversity of ring-hydroxylating dioxygenases involved in PAH biodegradation; strategies to engineer PCB-degrading bacteria; PCB-degrading plant-microbe systems strategies; the structure, regulation and diversity of microbial genes encoding biodegradative enzymes. In addition there are excellent reviews detailing the application of the state-of-the-art molecular technologies to study biodegradative processes. Technologies covered are community fingerprinting, molecular detection of degradative genes, and metagenomics for the analysis and monitoring of microorganisms in situ. These are complemented well by the fascinating reviews of the catabolic plasmids and mobile genetic elements involved in bioremediation, including discussions on the origin and evolution of these catabolic pathways to different genera. In addition the best procedures for the evaluation and design of relevant in situ remediation strategies are examined and classical ex-situ technologies such Landfarming, Composting, Biopiling and Slurry-phase bioremediation are described. This book is a vital reference resource for research scientists, graduate students, and other specialists interested on microbial bioremediation of organic pollutants and is recommended reading for environmental microbiologists, chemists and engineers." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x [1], 2-279 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Salvatore T. Butera and with a Foreword by Robert Schooley. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. x 1-309 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, bright and shiny, clean, unmarked interior. First Edition, First Printing. Replete with many score graphs, tables, charts, illustrations and photographs in black-and-white and full-color. Edited by Karen Mossman. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. vii [2], 2-265 pp. and with a range of full-color plates following, printed on high-gloss paper.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear to the glossy pictorial cloth over boards, apparently unread, spine still crackles. Double-column texts for ease of reading, a score of scientific papers by the two editors, Elisabeth Carniel and B. Joseph Hinnebusch, the editors, and by other recognized experts. From the publisher's blurb, "Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This and the emergence of antibiotic resistant Y. pestis in recent years highlight the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host and of the host response to a Yersinia infection; proteome analysis of the bacterial and host responses; treatment and antibiotic resistance; vaccines; surveillance and control. Essential reading for everyone working on Yersinia and related organisms and recommended reading for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence." Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. vii [3], 4-245 pp.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets. …

Hardcover. Zustand: As New. First Edition. Superior copy, gift-quality condition, inside and out, no discernible wear, bright and shiny dust jacket, apparently unread, spine still crackles. Contrbutions by the two edtors, Jeffrey M. Craig and Nicholas C. Wong, and by Moshe Szyf, Anne K. Voss and Tim Thomas, Brian P. Chadwick, Hongchang Cui, Samson Mani and Zdenko Herceg, Justin A. Fincher and Jonathan H. Dennis, Emma L. Northrop and Lee H. Wong, Sandra N. Oliver and E. Jean Finnegan and several others. Volume contains scholarly apparatus in the form of, e.g., notes, index, and bibliography. xii [2], 4-449 pp. plus a full-page, full-color plate.Member, I.O.B.A., C.B.A., and adherent to the highest ethical standards. Additional postage may be required for oversize or especially heavy volumes, and for sets.…