Arcade publishing okt 2018 (2 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - Winner of the Shirley Jackson Award. Named One of the Top 10 Thrillers to Read This Summer by Time Magazine. Misery meets The Vegetarian in this psychological thriller about loneliness and the dark truths we try to bury.In this tense, gripping novel by a star of Korean literature, Oghi has woken from a coma after causing a devastating car accident that took his wife's life and left him paralyzed and badly disfigured. His caretaker is his mother-in-law, a widow grieving the loss of her only child. Oghi is neglected and left alone in his bed. His world shrinks to the room he lies in and his memories of his troubled relationship with his wife, a sensitive, intelligent woman who found all of her life goals thwarted except for one: cultivating the garden in front of their house.But soon Oghi notices his mother-in-law in the abandoned garden, uprooting what his wife had worked so hard to plant and obsessively digging larger and larger holes. When asked, she answers only that she is finishing what her daughter started.A bestseller in Korea, The Hole is a superbly crafted and deeply unnerving novel about the horrors of isolation and neglect in all of its banal and brutal forms. As Oghi desperately searches for a way to escape, he discovers the difficult truth about his wife and the toll their life together took on her.…

Taschenbuch. Zustand: Neu. Neuware - 'A must-read for a 'behind the scenes' look at new drug development." Madelyn Fernstrom, PhD, NBC News Health Editor. The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter.The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity by chewing, brewing, and snortingsome Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances.Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes of drug hunters from the US, UK, Germany, and other nations.Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.…