Verlag: LAP LAMBERT Academic Publishing, 2020
ISBN 10: 6202557079 ISBN 13: 9786202557078
Sprache: Englisch
Anbieter: moluna, Greven, Deutschland
EUR 45,45
Währung umrechnenAnzahl: Mehr als 20 verfügbar
In den WarenkorbZustand: New.
Verlag: LAP LAMBERT Academic Publishing Mai 2020, 2020
ISBN 10: 6202557079 ISBN 13: 9786202557078
Sprache: Englisch
Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
EUR 54,90
Währung umrechnenAnzahl: 2 verfügbar
In den WarenkorbTaschenbuch. Zustand: Neu. Neuware -The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).Books on Demand GmbH, Überseering 33, 22297 Hamburg 104 pp. Englisch.