removal diffusible substances circulating (5 Ergebnisse)

Zustand: New. In.

Taschenbuch. Zustand: Neu. Neuware.

Zustand: New.

J. Pharm. exp. Ther., 5/3. - 1914, pp.275-316, orig. Broschur. PRECURSOR TO THE MODERN DAY DIALYSIS MACHINE! Rare Offprint "Reprinted from The Journal of Pharmacology and Experimental Therapeutics."! "Received for publication, December 18, 1913". "Together with Leonard George Rowntree (1883-1859) and Benjamin Bernard Turner 1971-1945), John Jacob Abel (1857-1938) devised what they called a "vividiffusion" apparatus, consisting of a series of tubes surrounded by fluid. They first demonstrated the apparatus at the Physiological Congress in Groningen in 1914. By allowing arterial blood to enter at one end of the connection, and later return to circulation through the venous connection after dialysis, they were able to demonstrate the existence of free amino acids in blood. By isolating these amino acids from blood circulation, Abel conducted various subsequent researches on the structure of proteins in the blood. Not only did Abel use the apparatus for his research work, he also realized the great clinical potential such dialysis machine would have on managing the damaging effects of renal failure. The vividiffusion apparatus Abel devised is the precursor to the modern day dialysis machine." He summarized his work in a paper published in 1913, "On the Removal of Diffusable Substances from the Circulating Blood by Means of Dialysis" by Transfusion Science. John Jacob Abel (1857-1938) was an American biochemist and pharmacologist. He established the pharmacology department at Johns Hopkins University School of Medicine in 1893, and then became America's first full-time professor of pharmacology. During his time at Hopkins, he made several important medical advancements, especially in the field of hormone extraction. In addition to his laboratory work, he founded several significant scientific journals such as the Journal of Biological Chemistry and the Journal of Pharmacology and Experimental Therapeutics. Garrison & Morton No. 741.2.

Abel, John Jacob (1857-1938); Rowntree, Leonard G.; and Turner, B. B. On the removal of diffusible substances from the circulating blood of living animals by dialysis. Offprint from J. Pharm. & Exp. Therapeutics 5 (1914). 8vo. 275-316pp. Text illustrations. 267 x 182 mm. Original printed wrappers, slightly chipped at bottom edge. Very good copy. First Separate Edition. Garrison-Morton 741.2. Abel, a student of Carl Ludwig and Johns Hopkins's first professor of pharmacology, made significant contributions to the development of biochemistry and pharmacology in the United States. In 1912, while investigating the protein constituents of the blood, Abel suggested that an "artificial kidney" might be used to remove and study constituents of the blood that are present only in minute amounts. "An apparatus of coiled collodion tubes surrounded by a saline solution was soon devised and used for this purpose; arterial blood was shunted through these tubes and then returned to the experimental animal's vein. . . . Even at this time, Abel seems to have been aware of the clinical potential of what he called his 'vividiffusion' apparatus; it might, he suggested, prove useful in managing renal failure" (DSB). To prevent blood clotting in his experimental animals, Abel used an anticoagulant obtained from leeches (hirudin); however, this was difficult to prepare and unsuitable for human use. Heparin, an anticoagulant occurring naturally in mammals, was discovered in 1916, but the use of dialysis as a clinical tool had to wait until 1937, when methods were developed to prepare large quantities of purified heparin extract. .