Protein coupled receptors structure function (15 Ergebnisse)

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Zustand: As New. Unread book in perfect condition.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Paperback. Zustand: Brand New. 336 pages. 9.50x6.50x1.00 inches. In Stock.

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Hardcover. Zustand: Brand New. 1st edition. 548 pages. 9.30x6.30x1.30 inches. In Stock.

Buch. Zustand: Neu. Neuware - G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.…

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Zustand: As New. Unread book in perfect condition.

Gebunden. Zustand: New. Structure-Function Analysis of G Protein-Coupled Receptors edited by Juergen Wess.G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, playing key roles in a remarkably large number of physiological and pathophysiological.

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Hardcover. Zustand: Brand New. 1st edition. 412 pages. 10.50x7.50x1.00 inches. In Stock.

Buch. Zustand: Neu. Neuware - G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters. Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes: \* An overview of mutagenesis techniques \* Examples of molecular modeling techniques \* Using peptides as tools for the study of GPCR interactions \* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin \* A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals \* The use of nuclear magnetic resonance techniques to study GPCR structure; Uber 40 Prozent der gegenwartig von Pharmakonzernen untersuchten pharmakologischen Targets stehen im Zusammenhang mit G-Protein-gekoppelten Rezeptoren (GPCRs). Bei der Untersuchung von Struktur, Eigenschaften und Funktion der GPCRs hilft dieser Band, der die aktuellsten molekulargenetischen, biochemischen und biophysikalischen Methoden zusammenfa t. Die erfahrenen Autoren bewerten jedes vorgestellte Verfahren im Hinblick auf verschiedene Anwendungen. (08/99).…

Zustand: New. G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Editor(s): Wess, Jurgen. Series: Receptor Biochemistry & Methodology. Num Pages: 432 pages, Illustrations (some col.). BIC Classification: PHVN; PSBC; PSD. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 254 x 179 x 31. Weight in Grams: 932. . 1999. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.…

Hardcover. Zustand: Brand New. 1st edition. 315 pages. 9.25x6.25x0.75 inches. In Stock.