Mouse brain development (13 Ergebnisse)
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Sprache: Englisch
Verlag: Springer, 2000
Serie: Buch 32 von 66 - Results and Problems in Cell Differentiation
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Zustand: Good. Your purchase helps support Sri Lankan Children's Charity 'The Rainbow Centre'. Ex-library, so some stamps and wear, but in good overall condition. Our donations to The Rainbow Centre have helped provide an education and a safe haven to hundreds of children who live in appalling conditions.
Sprache: Englisch
Verlag: Springer, 2000
Serie: Buch 32 von 66 - Results and Problems in Cell Differentiation
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Zustand: Very Good. 339 pp., hardcover, very good. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - In this project we bred together PDGF-B retention motif knockout (PDGF- Bret) mice and PDGF-C knockout mice for the first time to investigate the effect of combined PDGF-B and PDGF-C deficiency on mouse development and brain vasculature.PDGF-Bret/ret…;PDGF-C-/- double knockout mice were born dead and alive, but none survived weaning. Though severe oedema and haemorrhage was observed, they did not show any specific macroscopic malformation. The brain vasculature of new born (P0) PDGF-Bret/ret;PDGF-C-/- double knockout mice seemed to present a lower density and a more distorted architecture compared to PDGF-Bret/ret;PDGF-C+/-,PDGF-Bret/ret mice, but no significant changes could be shown.Comparing the brain vasculature of adult PDGF-Bret/ret;PDGF-C+/- and PDGF-Bret/ret mice we could not show significant differences of vascular density, but we were able to detect significant higher perimeter and length of the vessels in some parts of the brain. Looking at mural cells we could not show significant changes in pericyte architecture, but our observations suggest a thicker vSMC coverage of big vessels in PDGF-Bret/ret;PDGF-C+/- mice, an effect already described in PDGF-C-/-mice (Fredriksson et al., 2012).In conclusion, our data suggests that combined PDGF-B and PDGF-C deficiency in mice allows a normal macroscopic embryonic development, but limits surviving after birth presumably also due to severe malfunctions of the angiogenic system. Our histopathologic analysis of the brain vasculature underlines the described effect of PDGF-B and PDGF-C on the neurovascular unit, but suggests that the interaction and redundancy of these two PDGFs is not sufficiently distinct for a partial deficiency leading to extreme phenotypic changes.
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Taschenbuch. Zustand: Neu. The effect of combined PDGF-B and PDGF-C deficiency on mouse development and brain vasculature | Dissertationsschrift | Amrei Aufderheide | Taschenbuch | Deutsch | epubli | EAN 9783745058079 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]pre…igu[dot]de | Anbieter: preigu.
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Taschenbuch. Zustand: Neu. Parthenogenetic stem cell brain development in mouse embryos | Simone Margot Grieß-Porsch | Taschenbuch | Englisch | 2025 | Our Knowledge Publishing | EAN 9786208910617 | Verantwortliche Person für die EU: SIA OmniScriptum Publishing, Brivibas Gatve 197, 1039 RIGA, LETTLAND, customerservice[at]vdm-vsg[…dot]de | Anbieter: preigu.
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Taschenbuch. Zustand: Neu. The role of the Hr gene in brain, gut and thymus development in the mouse | Gene Hr (Hairless) | Olga Tacius (u. a.) | Taschenbuch | Englisch | 2021 | Our Knowledge Publishing | EAN 9786203500004 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[a…t]preigu[dot]de | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, 2012
Serie: Buch 32 von 66 - Results and Problems in Cell Differentiation
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics…. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Sprache: Englisch
Verlag: Springer, 1998
Serie: Buch 142 von 173 - Advances in Anatomy, Embryology and Cell Biology
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Zustand: New. In.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, 1998
Serie: Buch 142 von 173 - Advances in Anatomy, Embryology and Cell Biology
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The Reeler Mouse as a Model of Brain Development
Lambert de Rouvroit, Catherine (Author)/ Goffinet, Andre M. (Author)
Sprache: Englisch
Verlag: Springer, 1998
Serie: Buch 142 von 173 - Advances in Anatomy, Embryology and Cell Biology
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Paperback. Zustand: Brand New. 108 pages. 9.50x6.25x0.25 inches. In Stock.
Sprache: Englisch
Verlag: Springer, Springer Spektrum, 1998
Serie: Buch 142 von 173 - Advances in Anatomy, Embryology and Cell Biology
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of…enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation 'reeler is reelin' has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.
