heterogeneity asthma (14 Ergebnisse)

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Taschenbuch. Zustand: Neu. Heterogeneity in Asthma | Allan R. Brasier | Taschenbuch | xiv | Englisch | 2016 | Springer US | EAN 9781489978295 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Asthma is a chronic relapsing airways disease that represents a major public health problemworldwide. Intermittent exacerbations are provoked by airway mucosal exposureto pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representingthe two most common precipitants. In this setting, inducible signaling pathwaysthe airway mucosa play a central role in the initiation of airway inflammationthrough production of antimicrobial peptides (defensins), cytokines, chemokinesand arachidonic acid metabolites that coordinate the complex processes ofvascular permeability, cellular recruitment, mucous hyper-secretion, bronchialconstriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into thesubmucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, itis well appreciated that asthma is a heterogeneous in terms of onset,exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focuson a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensionalprofiling in asthma. This book willoverview multidimensional profiling strategies and visualization approaches forphenotyping asthma. As an outcome, thiswork will facilitate the understanding of disease etiology, prognosis and/ortherapeutic intervention.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Asthma is a chronic relapsing airways disease that represents a major public health problemworldwide. Intermittent exacerbations are provoked by airway mucosal exposureto pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representingthe two most common precipitants. In this setting, inducible signaling pathwaysthe airway mucosa play a central role in the initiation of airway inflammationthrough production of antimicrobial peptides (defensins), cytokines, chemokinesand arachidonic acid metabolites that coordinate the complex processes ofvascular permeability, cellular recruitment, mucous hyper-secretion, bronchialconstriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into thesubmucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, itis well appreciated that asthma is a heterogeneous in terms of onset,exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focuson a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensionalprofiling in asthma. This book willoverview multidimensional profiling strategies and visualization approaches forphenotyping asthma. As an outcome, thiswork will facilitate the understanding of disease etiology, prognosis and/ortherapeutic intervention.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Asthma is a common chronic respiratory disease that causes substantial morbidity and has beenchallenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. Toupdate the fieldonthe rapid advances in this field,Precision Approaches to Heterogeneity in Asthmafollows its highly successful predecessor,Heterogeneity in Asthma.In this new volume, noted authorities AllanRBrasier and NizarNJarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Asthma is a common chronic respiratory disease that causes substantial morbidity and has beenchallenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. Toupdate the fieldonthe rapid advances in this field,Precision Approaches to Heterogeneity in Asthmafollows its highly successful predecessor,Heterogeneity in Asthma.In this new volume, noted authorities AllanRBrasier and NizarNJarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions.

Hardcover. Zustand: Brand New. 1st edition. 354 pages. 9.25x6.25x1.00 inches. In Stock.

Zustand: New. This book presents an overview on multidimensional profiling strategies and visualization approaches for phenotyping asthma. It includes cutting-edge methods and protocols and provides step-by-step detail essential for reproducible results. Editor(s): Brasier, Allan R. Series: Advances in Experimental Medicine and Biology. Num Pages: 368 pages, 8 black & white illustrations, 25 colour illustrations, biography. BIC Classification: MBGR; MJL. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 20. Weight in Grams: 563. . 2016. Softcover reprint of the original 1st ed. 2014. Paperback. . . . . Books ship from the US and Ireland.

Zustand: New. This book presents an overview on multidimensional profiling strategies and visualization approaches for phenotyping asthma. It includes cutting-edge methods and protocols and provides step-by-step detail essential for reproducible results. Editor(s): Brasier, Allan R. Series: Advances in Experimental Medicine and Biology. Num Pages: 368 pages, 8 black & white illustrations, 25 colour illustrations, biography. BIC Classification: MBGR; MFG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 25. Weight in Grams: 754. . 2013. Hardback. . . . . Books ship from the US and Ireland.

Hardcover. Zustand: Brand New. 428 pages. 9.25x6.10x1.18 inches. In Stock.