development new triphasic oral (4 Ergebnisse)

Hardcover. Zustand: Fair. Unterschrift / Widmung ohne Bezug; Beschriftungen / Markierungen bis 20 %; Leichte Rillen / Abschürfungen / Risse / Knicke. R. B. GREENBLATT discusses the evolution of oral contraceptives, highlighting that early formulations contained higher doses of oestrogen (ethinyloestradiol or mestranol) and progestagen (norethynodrel or norethisterone) than necessary for effective conception control. Over time, there has been a trend towards reducing these dosages to minimize side effects while maintaining efficacy. However, lower dosages have led to increased instances of spotting and breakthrough bleeding in the initial months of use. The sequential pill, which aimed to align more closely with physiological principles, required larger doses of oestrogen to prevent ovulation, resulting in a higher pregnancy rate and making it less appealing. A new triphasic formulation has emerged that leverages the synergy between ethinyloestradiol and levonorgestrel, allowing for low doses of oestrogen and very low doses of progestagen to be used effectively. This preparation is associated with fewer side effects, adhering to the pharmacological principle of minimal dosing for desired outcomes. The regimen divides the cycle into three phases, using varying doses of oestrogen over 21 days, closely mimicking the natural hormonal fluctuations in the menstrual cycle.

Zustand: New. In.

Paperback. Zustand: Brand New. 1984 edition. 132 pages. 8.50x5.51x0.30 inches. In Stock.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - R. B. GREENBLATT The original oral contraceptives contained more oestrogen in the form of ethinyloestradiol or mestranol and progestagen in the form of norethynodrel or norethisterone than was necessary f(x conception control. There has been a trend over the years to reduce dosages of both components in order to minimize side eHects while ensuring eflcctiveness. However, as dosages were lowered, there has been an increase in spotting and break through bleeding during the first few months of their adminis tration. The sequential pill appeared more physiological in that it followed more closely physiological principles, but the need to employ large doses ofEE or EE3ME to inhibit O'ulation and the higher pregnancy rate made the sequential regimen less attrac ti'e or useful. A triphasic formulation has become available that takes advantage of the synergism between ethinyloestradiol and the potent levonorgestrel so that low doses of the oestrogen and very low doses of the progestagen could be employed with great effectiveness. Such a preparation is relatively free from side effects, partly because the basic pharmacological tenet of the minimal dose for the desired result and the division of'the cycle into three parts using 30 ,lIg ofEE for the first 6 days, then:) days of 40 ,lIg, followed by 30 ,fIg for 10 da ys, for a total of21 days, thus more or less mimicking the physiological rise and fall of 125 THE DEVELOP:'IE:-;T OF , :-;E' TRIPH. SIC OR.