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Verlag: Humana Press, 1996
ISBN 10: 0896034607ISBN 13: 9780896034600
Anbieter: moluna, Greven, Deutschland
Buch
Zustand: New.
Verlag: Humana Press, 1996
ISBN 10: 0896034607ISBN 13: 9780896034600
Anbieter: Rheinberg-Buch Andreas Meier eK, Bergisch Gladbach, Deutschland
Buch
Gebundene Ausgabe. Zustand: Gebraucht. Gebraucht - Sehr gut Leichte Lagerspuren -Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. 'Screening' remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism. 451 pp. Englisch.
Verlag: Springer, 2010
ISBN 10: 1617370460ISBN 13: 9781617370465
Anbieter: bookmarathon, Emmendingen, BW, Deutschland
Buch
Zustand: Sehr gut. 464 Seiten Leichte Lagerspuren! Sie erhalten eine Rechnung mit der darin ausgewiesenen MwSt. Sprache: Englisch Gewicht in Gramm: 2015 17,8 x 2,7 x 25,4 cm, Taschenbuch Auflage: Softcover reprint of the original 1st ed. 1997.