Analysis aggregates particles protein (6 Ergebnisse)

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Zustand: New. In English.

Hardcover. Zustand: Brand New. 1st edition. 443 pages. 9.75x6.75x1.00 inches. In Stock.

Buch. Zustand: Neu. Neuware - This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy. Enables researchers to better detect, measure, and characterize aggregates and particles during protein drug developmentFeaturing contributions from leading pharmaceutical investigators around the world, this text enables researchers to choose the most appropriate analytical methods in order to detect and characterize the full spectrum of protein aggregates and particles that can be present in a protein pharmaceutical. Moreover, the authors provide detailed examples of how these methods can be applied during both process and formulation development, helping researchers better manage the problem of protein instability as they seek to develop protein drugs.The text begins with an introduction to aggregates and particles, focusing on their potential immunogenicity. Next, it covers:Methods to detect and measure soluble aggregates based on separation, light scattering, and new technologyMethods to detect and measure insoluble aggregates and both sub-visible and visible particlesSpectroscopic techniques such as UV/VIS, fluorescence, infrared and Raman spectroscopy, and microscopy to characterize aggregates and particles, elucidate their structures, and identify proteinaceous and non-proteinaceous particlesComparative advantages and disadvantages of the methods for protein aggregate analysisApproaches for managing aggregates and particles found during protein purification and formulation developmentThroughout the text, case studies help researchers deal with the challenges that arise in detecting and analyzing protein aggregates and particles.Protein pharmaceuticals are increasingly used to treat life-threatening and chronic diseases, including cancer, viral infections, metabolic disorders, and central nervous system diseases. With Analysis of Aggregates and Particles in Protein Pharmaceuticals as their guide, pharmaceutical researchers now have an important tool in overcoming the challenging problem of aggregates and particles in protein drug development.…

Buch. Zustand: Neu. Analysis of Aggregates and Particles in Protein Pharmaceuticals | H-C Mahler | Buch | Contributors ixPreface xiiiGlossary xv1 The Critical Need for Robust Assays for Quantitation and Characterization of Aggregates of Therapeutic Proteins 1John F. Carpenter | Englisch | 2012 | John Wiley & Sons Inc | EAN 9780470497180 | Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, 36244 Bad Hersfeld, gpsr[at]libri[dot]de | Anbieter: preigu.…

Gebundene Ausgabe. Zustand: Wie neu. 464 Seiten; Buchdeckel minimal berieben/bestossen. Innenteil tadellos - u n g e l e s e n - keine Risse, Knicke, Anmerkungen. ! Altersbedingt minimal nachgedunkelt! KEIN Mängelexemplar! Versand aus München V1262 Sprache: Deutsch Gewicht in Gramm: 798.