Isbn: 9783764382377 - new therapeutic targets in rheumatoid arthritis (progress in inflammation research) (7 Ergebnisse)

21 ills., 5 in color. XII, 225 p. Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Stamped. Progress in Inflammation Research.…

Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.

Zustand: New. In English.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - During the past decades important breakthroughs have been made in the treatment of rheumatoid arthritis (RA). First, the implementation of low-dose methotrexate and other conventional disease-modifying anti-rheumatic drugs was introduced as an effective treatment. Second, it was recognized that early immunomodu- tory treatment is crucial for controlling the disease and its long-term destructive effects more effectively. Parallel advances in research on the pathogenesis of RA and cytokine biology converged in identifying tumor necrosis factor (TNF) as a key factor in inflammation and matrix destruction. The concept arose that elevated TNF concentrations at the sites of inflammation were driving disease pathology, and the removal of excess TNF from sites of inflammation became a therapeutic goal. Clearly, TNF blockade has revolutionized the treatment of RA, as well as other immune-mediated inflammatory diseases. Anti-TNF treatment results in cli- cal benefit in a significant proportion of the patients, and it has provided proof of concept for the principle of targeted therapy. Despite the impressive disease-modifying effects of the TNF blockers, not all patients respond, and patients who exhibited an initial response may lose response due to the development of anti-drug antibodies (human anti-chimeric antibodies and human anti-human antibodies, respectively) and perhaps as a result of escape mechanisms related to the disease process. In fact, the majority of the patients still have disease activity in at least one or two actively inflamed joints.…

Zustand: New. Focuses on therapeutic targets that&nbsphave recently been registered or are currently under development.Each chapter discusses the biological rationale in great detail including results from clinical trials.Written by an international aut.

Hardcover. Zustand: Brand New. 1st edition. 225 pages. 9.25x6.75x0.75 inches. In Stock.

Zustand: New. Focuses on therapeutic targets that were identified after TNF blockade. This book discusses the biological rationale in detail, including in vitro work and work in animal models, and where appropriate, results form clinical trials. It is of interest to rheumatologists, immunologists, internists, and investigators in immunology and rheumatology. Editor(s): Tak, Paul-Peter. Series: Progress in Inflammation Research. Num Pages: 228 pages, 9 black & white tables, biography. BIC Classification: MJE. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 18. Weight in Grams: 703. . 2008. Hardback. . . . . Books ship from the US and Ireland. …