9783662512944 - programmed cells from basic neuroscience to therapy (research and perspectives in neurosciences, band 20) (4 Ergebnisse)
Programmed Cells from Basic Neuroscience to Therapy (Research and Perspectives in Neurosciences, 20)
Sprache: Englisch
Verlag: Springer, 2016
Serie: Research and Perspectives in Neurosciences, Buch 10 von 14. Buch 10 von 14 - Research and Perspectives in Neurosciences
- Softcover
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Zustand: New. In.
Sprache: Englisch
Verlag: Springer, 2016
Serie: Research and Perspectives in Neurosciences, Buch 10 von 14. Buch 10 von 14 - Research and Perspectives in Neurosciences
- Softcover
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Taschenbuch. Zustand: Neu. Programmed Cells from Basic Neuroscience to Therapy | Fred H. Gage (u. a.) | Taschenbuch | xii | Englisch | 2016 | Springer | EAN 9783662512944 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer, Berlin, Springer Berlin Heidelberg, Springer, 2016
Serie: Research and Perspectives in Neurosciences, Buch 10 von 14. Buch 10 von 14 - Research and Perspectives in Neurosciences
- Softcover
Anbieter: AHA-BUCH GmbH, Einbeck, DeutschlandAHA-BUCH GmbH
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an impor…tant tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson's Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called 'disease-in-a-dish' approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling differentneurological diseases.
Sprache: Englisch
Verlag: Springer Verlag, 2016
Serie: Research and Perspectives in Neurosciences, Buch 10 von 14. Buch 10 von 14 - Research and Perspectives in Neurosciences
- Softcover
Anbieter: Revaluation Books, Exeter, Vereinigtes KönigreichRevaluation Books
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Paperback. Zustand: Brand New. reprint edition. 144 pages. 9.30x6.20x0.34 inches. In Stock.
