9783662225653 - trinucleotide diseases and instability (results and problems in cell differentiation, band 21) (4 Ergebnisse)
Sprache: Englisch
Verlag: Springer 2013
Serie: Results and Problems in Cell Differentiation, Buch 13 von 66. Buch 13 von 66 - Results and Problems in Cell Differentiation
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Sprache: Englisch
Verlag: Springer 2013
Serie: Results and Problems in Cell Differentiation, Buch 13 von 66. Buch 13 von 66 - Results and Problems in Cell Differentiation
- Softcover
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Paperback. Zustand: Brand New. reprint edition. 180 pages. 9.25x6.10x0.41 inches. In Stock.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg 2013
Serie: Results and Problems in Cell Differentiation, Buch 13 von 66. Buch 13 von 66 - Results and Problems in Cell Differentiation
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Till recently, mutations in genes were described in textbooks as deletions or point mutations. These mutations can be inherited from a parent or they are de novo alterations. The discovery in 1991 that human disease can be caused by large-scale ex pa…nsion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. In the subsequent years more then 10 such disease genes have been identified. All dynamic mutations have been iden tified in neurological disorders. There are ten possible trinucleotide repeats at the DNA level, but only 3 have been identified as being involved in human dis eases. The rather frequent occurence of triplet repeats in the human genome indicates that other loci subject to unstable expansions may be discovered. The identification of repeat instability and the identification of disease genes containing trinucleotide repeats has helped to answer intriguing questions. The diseases share the unusual characteristic of inheritance with increased disease severity in successive gernerations, a phenomenon called anticipation. Trinu cleotide repeat diseases are ideal subjects for direct testing because the muta tion is almost exclusively of the same type and there is an extremely low occur ance of new mutations in these diseases. The anticipation can now be explained by the correlation of increasing repeat length with increased disease serverity. It can be speculated that other neurological disorders showing anticipation will be caused by unstable repeats as well.
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Verlag: Springer 2013
Serie: Results and Problems in Cell Differentiation, Buch 13 von 66. Buch 13 von 66 - Results and Problems in Cell Differentiation
- Softcover
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Taschenbuch. Zustand: Neu. Trinucleotide Diseases and Instability | Ben A. Oostra | Taschenbuch | ix | Englisch | 2013 | Springer | EAN 9783662225653 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
