Isbn: 9783642630170 - signal transduction and the coordination of b lymphocyte development and function i: transduction of bcr signals from the cell membrane to the nucleus (current topics in microbiology and immunology) (5 Ergebnisse)

Zustand: New. In English.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.…

Paperback. Zustand: Brand New. 288 pages. 9.25x6.10x0.65 inches. In Stock.

Taschenbuch. Zustand: Neu. Signal Transduction and the Coordination of B Lymphocyte Development and Function I | Transduction of BCR Signals from the Cell Membrane to the Nucleus | Louis B. Justement (u. a.) | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2012 | Springer | EAN 9783642630170 | Verantwortliche Person für die EU: Lauinger, Sonia, Sonia Lauinger, Lauinger Verlag, Heinrich-Köhler-Platz 8, 76187 Karlsruhe, mail[at]lauinger-verlag[dot]de | Anbieter: preigu.…

Zustand: New.