Isbn: 9783540530220 - recent progress in the genetic epidemiology of cancer (3 Ergebnisse)

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Paperback. Zustand: Brand New. 1st edition. 173 pages. 9.25x6.10x0.41 inches. In Stock.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the 'genetic model') for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a 'history' for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) 'ascertainment sampling' by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree.…