9783540306344 - modelling and optimization of biotechnological processes: artificial intelligence approaches (studies in computational intelligence, 15, band 15) von chen, lei zhi; nguang, sing kiong; chen, xiao dong (2 Ergebnisse)
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Mostindustrialbiotechnologicalprocessesareoperatedempirically.Oneofthe major di culties of applying advanced control theories is the highly nonlinear nature of the processes. This book examines approaches based on arti cial intelligencemethods,inparticular,…geneticalgorithmsandneuralnetworks,for monitoring, modelling and optimization of fed-batch fermentation processes. The main aim of a process control is to maximize the nal product with minimum development and production costs. This book is interdisciplinary in nature, combining topics from biotechn- ogy, arti cial intelligence, system identi cation, process monitoring, process modelling and optimal control. Both simulation and experimental validation are performed in this study to demonstrate the suitability and feasibility of proposed methodologies. An online biomass sensor is constructed using a - current neural network for predicting the biomass concentration online with only three measurements (dissolved oxygen, volume and feed rate). Results show that the proposed sensor is comparable or even superior to other sensors proposed in the literature that use more than three measurements. Biote- nological processes are modelled by cascading two recurrent neural networks. It is found that neural models are able to describe the processes with high accuracy. Optimization of the nal product is achieved using modi ed genetic algorithms to determine optimal feed rate pro les. Experimental results of the corresponding production yields demonstrate that genetic algorithms are powerful tools for optimization of highly nonlinear systems. Moreover, a c- bination of recurrentneural networks and genetic algorithms provides a useful and cost-e ective methodology for optimizing biotechnological processes.
