Isbn: 9783527353606 - targeting protein-protein interactions for drug discovery (7 Ergebnisse)

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Buch. Zustand: Neu. Neuware - Up-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeuticsTargeting Protein Protein Interactions for Drug Discovery provides a systematic and comprehensive overview of protein-protein interactions (PPIs), reviewing foundational concepts, advanced methodologies, and emerging therapeutic strategies, reflecting the multidisciplinary nature of PPI research.This book discusses computational methods for predicting PPI structures, with a special emphasis on protein docking and deep learning-based approaches, diverse chemical scaffolds for PPI modulation, including foldamers as inhibitors of aberrant PPIs and sulfonyl-¿-AApeptides as novel modulators, and the development and application of stapled peptides as modulators of intracellular PPIs, offering enhanced stability, binding affinity, and cellular permeability.Readers will also find information on cyclic peptides, focusing on their unique conformational stabilization and therapeutic potential across a range of diseases, small molecule inhibitors targeting BCL-family proteins, revealing their potential in cancer therapy, molecular glues as activators for PPIs, categorized into degraders, stabilizers, and inhibitors based on their biological effects, and the targeting of the APC Asef interaction for drug discovery in colorectal cancer therapy, offering a case study of specificity and clinical relevance.Targeting Protein Protein Interactions for Drug Discovery explores sample topics including:\* Challenges and strategies of drug discovery targeting PPIs, including high-throughput screening and structure-based drug design\* Fluorescence resonance energy transfer (FRET) technology, a powerful tool for real-time analysis of molecular interactions in live cells\* Utility of mass spectrometry (MS) for large-scale mapping of PPI networks with high sensitivity and resolution\* Proximity ligation assays (PLA) for detecting PPIs in situ, emphasizing spatial precision and adaptability for multiplexed detection\* Application of surface plasmon resonance (SPR) for characterizing PPI specificity, affinity, and kineticsExploring both classical and novel approaches to PPI characterization and modulation, Targeting Protein Protein Interactions for Drug Discovery offers a comprehensive reference for researchers aiming to unlock the therapeutic potential of PPIs along with educators and students engaged in the study of cellular mechanisms, drug discovery, and biotechnology.…

Buch. Zustand: Neu. Neuware -Up-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeuticsWiley-VCH GmbH, Boschstraße 12, 69469 Weinheim 432 pp. Englisch.

Zustand: Hervorragend. Zustand: Hervorragend | Seiten: 432 | Sprache: Englisch | Produktart: Bücher | Up-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeutics Targeting Protein-Protein Interactions for Drug Discovery provides a systematic and comprehensive overview of protein-protein interactions (PPIs), reviewing foundational concepts, advanced methodologies, and emerging therapeutic strategies, reflecting the multidisciplinary nature of PPI research. This book discusses computational methods for predicting PPI structures, with a special emphasis on protein docking and deep learning-based approaches, diverse chemical scaffolds for PPI modulation, including foldamers as inhibitors of aberrant PPIs and sulfonyl-¿-AApeptides as novel modulators, and the development and application of stapled peptides as modulators of intracellular PPIs, offering enhanced stability, binding affinity, and cellular permeability. Readers will also find information on cyclic peptides, focusing on their unique conformational stabilization and therapeutic potential across a range of diseases, small molecule inhibitors targeting BCL-family proteins, revealing their potential in cancer therapy, molecular glues as activators for PPIs, categorized into degraders, stabilizers, and inhibitors based on their biological effects, and the targeting of the APC-Asef interaction for drug discovery in colorectal cancer therapy, offering a case study of specificity and clinical relevance. Targeting Protein-Protein Interactions for Drug Discovery explores sample topics including: - Challenges and strategies of drug discovery targeting PPIs, including high-throughput screening and structure-based drug design - Fluorescence resonance energy transfer (FRET) technology, a powerful tool for real-time analysis of molecular interactions in live cells - Utility of mass spectrometry (MS) for large-scale mapping of PPI networks with high sensitivity and resolution - Proximity ligation assays (PLA) for detecting PPIs in situ, emphasizing spatial precision and adaptability for multiplexed detection - Application of surface plasmon resonance (SPR) for characterizing PPI specificity, affinity, and kinetics Exploring both classical and novel approaches to PPI characterization and modulation, Targeting Protein-Protein Interactions for Drug Discovery offers a comprehensive reference for researchers aiming to unlock the therapeutic potential of PPIs along with educators and students engaged in the study of cellular mechanisms, drug discovery, and biotechnology.…

Buch. Zustand: Neu. Neuware -Up-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeutics Targeting Protein-Protein Interactions for Drug Discovery provides a systematic and comprehensive overview of protein-protein interactions (PPIs), reviewing foundational concepts, advanced methodologies, and emerging therapeutic strategies, reflecting the multidisciplinary nature of PPI research. This book discusses computational methods for predicting PPI structures, with a special emphasis on protein docking and deep learning-based approaches, diverse chemical scaffolds for PPI modulation, including foldamers as inhibitors of aberrant PPIs and sulfonyl-¿-AApeptides as novel modulators, and the development and application of stapled peptides as modulators of intracellular PPIs, offering enhanced stability, binding affinity, and cellular permeability. Readers will also find information on cyclic peptides, focusing on their unique conformational stabilization and therapeutic potential across a range of diseases, small molecule inhibitors targeting BCL-family proteins, revealing their potential in cancer therapy, molecular glues as activators for PPIs, categorized into degraders, stabilizers, and inhibitors based on their biological effects, and the targeting of the APC-Asef interaction for drug discovery in colorectal cancer therapy, offering a case study of specificity and clinical relevance. Targeting Protein-Protein Interactions for Drug Discovery explores sample topics including: - Challenges and strategies of drug discovery targeting PPIs, including high-throughput screening and structure-based drug design - Fluorescence resonance energy transfer (FRET) technology, a powerful tool for real-time analysis of molecular interactions in live cells - Utility of mass spectrometry (MS) for large-scale mapping of PPI networks with high sensitivity and resolution - Proximity ligation assays (PLA) for detecting PPIs in situ, emphasizing spatial precision and adaptability for multiplexed detection - Application of surface plasmon resonance (SPR) for characterizing PPI specificity, affinity, and kinetics Exploring both classical and novel approaches to PPI characterization and modulation, Targeting Protein-Protein Interactions for Drug Discovery offers a comprehensive reference for researchers aiming to unlock the therapeutic potential of PPIs along with educators and students engaged in the study of cellular mechanisms, drug discovery, and biotechnology. 432 pp. Englisch.…

Hardcover. Zustand: gut. 2025. Targeting Protein-Protein Interactions for Drug Discovery In deutscher Sprache. pages.