Isbn: 9783319817040 - pi3k-mtor in cancer and cancer therapy (cancer drug discovery and development) (5 Ergebnisse)

Zustand: New. In English.

Taschenbuch. Zustand: Neu. PI3K-mTOR in Cancer and Cancer Therapy | Nandini Dey (u. a.) | Taschenbuch | Cancer Drug Discovery and Development | xxiv | Englisch | 2018 | Springer | EAN 9783319817040 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.…

Zustand: New. 2018. Paperback. . . . . . Books ship from the US and Ireland.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - In the post human-genome project era, cancer specific genomic maps are redesigningtumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that controlbeneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchersabout the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumorsis sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includestwo complementary parts which addressthe problem of etiology and disease progression and isintended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in variousfacetsof the cancer, includingstem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significantprogresshas been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relationto the PI3K-mTOR pathway and this volumeprovides an in-depth overview of recent developments made in this area.…

Paperback. Zustand: Brand New. reprint edition. 320 pages. 9.25x6.10x0.76 inches. In Stock.