9781607618539 - Computational Biology of Transcription Factor Binding (Methods in Molecular Biology, 674, Band 674) (4 Ergebnisse)

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Zustand: New. Authoritative and easy to use, this volume examines the computational analysis of the biological interpretations of transcription factor binding. Cutting-edge protocols for computer biologists are presented, in addition to tricks-of-the-trade from experts in the field. Editor(s): Ladunga, Istvan. Series: Methods in Molecular Biology. Num Pages: 454 pages, 23 black & white tables, biography. BIC Classification: PSA; PSBC. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 30. Weight in Grams: 1063. . 2010. Hardback. . . . . Books ship from the US and Ireland.

Hardcover. Zustand: Brand New. 415 pages. 10.50x7.25x1.50 inches. In Stock.

Zustand: Sehr gut. Zustand: Sehr gut | Seiten: 468 | Sprache: Englisch | Produktart: Bücher | Transcriptional regulation controls the basic processes of life. Its complex, dynamic, and hierarchical networks control the momentary availability of messenger RNAs for protein synthesis. Transcriptional regulation is key to cell division, development, tissue differen- ation, and cancer as discussed in Chapters 1 and 2. We have witnessed rapid, major developments at the intersection of computational biology, experimental technology, and statistics. A decade ago, researches were struggling with notoriously challenging predictions of isolated binding sites from low-throughput experiments. Now we can accurately predict cis-regulatory modules, conserved cl- ters of binding sites (Chapters 13 and 15), partly based on high-throughput ch- matin immunoprecipitation experiments in which tens of millions of DNA segments are sequenced by massively parallel, next-generation sequencers (ChIP-seq, Chapters 9, 10, and 11). These spectacular developments have allowed for the genome-wide mappings of tens of thousands of transcription factor binding sites in yeast, bacteria, mammals, insects, worms, and plants. Please also note the no less spectacular failures in many laboratories around the world.