EUR 180,07
Anzahl: Mehr als 20 verfügbar
In den WarenkorbZustand: New.
Anbieter: Ria Christie Collections, Uxbridge, Vereinigtes Königreich
EUR 228,94
Anzahl: Mehr als 20 verfügbar
In den WarenkorbZustand: New. In.
Taschenbuch. Zustand: Neu. Cancer Genome and Tumor Microenvironment | Andrei Thomas-Tikhonenko | Taschenbuch | Cancer Genetics | ix | Englisch | 2012 | Springer | EAN 9781461425243 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer New York, Springer US, 2012
ISBN 10: 1461425247 ISBN 13: 9781461425243
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are 'soft-wired', i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
Anbieter: Revaluation Books, Exeter, Vereinigtes Königreich
EUR 307,02
Anzahl: 2 verfügbar
In den WarenkorbPaperback. Zustand: Brand New. 489 pages. 9.25x6.10x1.03 inches. In Stock.