Isbn: 9781402001468 - advances in prostaglandin and leukotriene research: basic science and new clinical applications (medical science symposia series, band 16) (4 Ergebnisse)

Zustand: New. In English.

Zustand: New. Preface. List of Contributors. I: Lipoxygenases and Leukotriene Biosynthesis. 1. Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases O. Werz, et al. 2. 5-Lipoxygenase and the Nucleus: Where, When, How, and Why? M. Peter.

Zustand: New. Features the proceedings of the 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, held in Florence, Italy, on June 4-8, 2000. At this meeting particular emphasis was given to the potential application of the novel COX-2 inhibitors. Editor(s): Samuelsson, B.; Paoletti, Rodolfo; Folco, Gian Carlo; Granstrom, E. Karolinska; Nicosia, S. Series: Medical Science Symposia. Num Pages: 206 pages, biography. BIC Classification: MFG; PSB. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 235 x 155 x 14. Weight in Grams: 1110. . 2002. Hardback. . . . . Books ship from the US and Ireland.…

Buch. Zustand: Neu. Neuware - I Lipdxygenases and Leukotriene Biosynthesis.- 1. Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases.- 2. 5-Lipoxygenase and the Nucleus: Where, When, How, and Why .- 3. Calcium Binding Site of 5-Lipoxygenase.- 4. Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases.- 5. Novel Aspects Related to Biosynthesis and Biological Actions of Hepoxilins: Interrelationship with Phospholipid Hydro-Peroxide Glutathione Peroxidase (PHGPx).- 6. Transcriptional Regulation of the Human Leukotriene C4 Synthase Promoter.- 7. Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis.- II Cyclooxygenases and Prostaglandin Biosynthesis.- 8. Regulation of COX-2 Expression in Fibroblasts, Osteoblasts, Mast Cells, and Macrophages.- 9. Antimicroinflammatory Lipid Signals from Vascular Cyclooxygenase-2: A Novel Mechanism for NSAID and N-3 PUFA Therapeutic Actions.- 10. Substrate Interactions in the Cyclooxygenase-1 Active Site.- 11. Mutation of the Human Prostacyclin Synthase Gene.- 12. Structure and Function of Two Distinct Types of Prostaglandin D Synthase.- 13. Roles of Prostaglandin F Synthase.- 14. Differential Effects of Nitric Oxide on Cyclooxygenase 1 and 2 Activities in Cultured Cells.- III Phospholipase A2.- 15. On the Functional Diversity of Secreted Phospholipases A2: Cloning of Novel Mammalian and HIV-1 Antiviral Properties.- 16. Regulation of Cytosolic Phospholipase A2 by Phosphorylation.- IV Cytochrome P450 Archidonate Metabolites.- 17. Synthesis and Function of 20-Hydroxyeicosatetraenoic Acid in the Kidney.- V Receptors.- 18. Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice.- 19. Induction of Prostaglandin I2 Receptor in Murine Osteoblastic Cell.- 20. BLT2, aSecond Leukotriene B4 Receptor.- 21. Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes.- 22. Physiological and Pathophysiological Roles of Prostanoids; Lessons from Receptor-Knockout Mice for Clinical Applications.- 23. Multiple G-Protein Coupling of Chimeric Prostacyclin/Prostaglandin D2 Receptors.- VI Eicosanoids and Neuroscience.- 24. An Unusual Nicotinic Acetylcholine Receptor Activates the 8-Lipoxygenase Pathway in Aplysia Neurons.- VII Cardiovascular System.- 25. Neutrophil-Endothelial Cell Interaction: A Multidirectional Cross-Talk in Leukotriene Generation.- 26. Cyclooxygenase in the Lamb Ductus Arteriosus: Developmental Changes and Upregulation.- 27. Co-Localization of Prostacyclin (PGI2)-Synthase and Caveolin-1 in Endothelial Cells Underscores New Roles of PGI2 In Angiogenesis.- VIII Respiratory System.- 28. Leukotriene C4 Synthase Gene Polymorphism in Severe Asthma.- IX Inflammation.- 29. Anti-Inflammatory Levels of Aspirin and Salicylate Inhibit Integrin-Dependent Human Neutrophil Aggregation and PMN Influx in COX2- and NFkB(P105)- Knockout Mice.- 30. Antipyretic Action of Acetaminophen: Inhibition of the Cyclooxygenase Activity of Endothelial Cells Treated with IL-1.- 31. Leukotriene-Mediated Alteration of Endothelial Barrier Function.- 32. GI and Cardiovascular Profiles of New NSAIDs: Selective COX-2 Inhibitors and NO-NSAIDs.- 33. NO-Releasing NSAIDs Modulate Cytokine Secretion.- 34. Potent Inhibitory Effects of a NO-NSAID (Flurbiprofen Nitroxybutylester) on Bone Resorption in Vitro and in Vivo.- X Cancer.- 35. Lipid Peroxidation and Cyclooxygenase-2 Activity in Human Hepatocellular Carcinoma Cell Lines with and without Multiple Drug Resistance: Correlation with Cell Growth.- 36. Pulmonary Prostacyclin Synthase Overexpression Improves Survival Following Butylated Hydroxytoluene Exposure.- XI Isoprostanes.- 37. Reactive Products of the Isoprostane Pathway: Isoketals and Cyclopentenone A2/J2-Isoprostanes.- 38. Increased Isoprostane 8-epi-PGF2A in Statin-Induced Myopathy.…