9780470281741 - Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad (7 Ergebnisse)

Zustand: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Zustand: New. xiii 854 8 of lates Illus.

HRD. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

Gebunden. Zustand: New. Chuang Lu, PhD, is the Associate Director in the Drug Safety and Disposition Department of Millennium Pharmaceuticals. His current research interests include drug-metabolizing enzymes, drug-drug interaction, and in vitro-in vivo correlation.Albert P. Li, Ph.

Hardcover. Zustand: Brand New. 1st edition. 854 pages. 10.00x6.25x1.75 inches. In Stock.

Zustand: New. This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition. Editor(s): Lu, Chuang; Li, Albert P. Num Pages: 868 pages, Illustrations. BIC Classification: MJ; MMG; PN. Category: (P) Professional & Vocational. Dimension: 244 x 167 x 44. Weight in Grams: 1324. . 2010. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Buch. Zustand: Neu. Neuware - The science and applied approaches of enzyme inhibition in drug discovery and developmentOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the 'good' inhibitions--desirable pharmacological effects--and 'bad' inhibitions--drug-drug interactions and toxicity. The book discusses:\* The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\* The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions\* The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathwayThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.