Yen paul (14 Ergebnisse)
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Zustand: New. pp. 1044.
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Sprache: Englisch
Verlag: Springer New York, 2016
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
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Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, t…he molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a ¿repressor¿ of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ¿.
Sprache: Englisch
Verlag: Springer, 2018
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
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Sprache: Englisch
Verlag: Springer, 2016
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
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Weitere BilderSprache: Englisch
Verlag: Springer, 2018
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
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Taschenbuch. Zustand: Neu. Thyroid Hormone Disruption and Neurodevelopment | Noriyuki Koibuchi (u. a.) | Taschenbuch | viii | Englisch | 2018 | Springer | EAN 9781493981243 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer New York, Springer US, 2016
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
- Hardcover
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the mole…cular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first bookto comprehensively describethe effect of thyroid hormone disruptionin the central nervous system.The first section deals with the disruption of thyroid hormone action at themolecular level. Firstthe authorsprovide a summary ofthe possible molecular mechanisms of thyroid hormone action in the brain, thenthey discussseveral factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a'repressor' of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanismsthat createeach abnormal phenotype are not fully understood.
Sprache: Englisch
Verlag: Springer, Springer, 2018
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
- Softcover
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, t…he molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first bookto comprehensively describethe effect of thyroid hormone disruptionin the central nervous system.The first section deals with the disruption of thyroid hormone action at themolecular level. Firstthe authorsprovide a summary ofthe possible molecular mechanisms of thyroid hormone action in the brain, thenthey discussseveral factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a'repressor' of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanismsthat createeach abnormal phenotype are not fully understood.
Sprache: Englisch
Verlag: Springer, 2016
Serie: Contemporary Clinical Neuroscience, Buch 13 von 20. Buch 13 von 20 - Contemporary Clinical Neuroscience
- Hardcover
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Imposture et fiction dans les récits d'Ancien Régime : Actes du 27e colloque international de la SATOR à l'université Sorbonne Nouvelle Paris 3, les 12-13 et 14 juin 2013
Kremer, Nathalie/ Sermain, Jean-Paul/ Tran-Gervat, Yen-Maï/ Collectif
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Paperback. Zustand: Brand New. French language. 8.43x5.85x0.73 inches. In Stock.
