shinde anilkumar (148 Ergebnisse)

PAP. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

PAP. Zustand: New. New Book. Shipped from UK. Established seller since 2000.

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Paperback. Zustand: Brand New. 52 pages. 8.66x5.91x0.12 inches. In Stock.

Taschenbuch. Zustand: Neu. Neuware -The present investigation was to formulation and development of fast dissolving mucoadhesive buccal film of nebivolol by using solvent casting method. Nebivolol is a third-generation cardio selective ¿1-blocker undergoes extensive metabolism in the liver, gastrointestinal disturbance, abdominal pain after its oral administration and resulting in to a poor bioavailability (10-12%). In order to improve the bioavailability, efficacy and minimize the side effects associated with oral administration. Prepared mucoadhesive buccal films using HPMC E15 and PVP as mucoadhesive polymers. Among the two polymers HPMC E15 showed an increased in-vitro residence time due to high mucoadhesive property. Mucoadhesive buccal films were evaluated by weight variation, thickness, folding endurance, pH, in vitro disintegration, in vitro dissolution, tensile strength and drug content. In-vitro drug release study was showed more than 98.19±0.02% drug released within 40 min. The tensile strength of formulation SW9 was found 50.00 N/mm2. Thus it can concluded that the prepared formulation of buccal mucoadhesive film can be a novel treatment for myocardial infarction and angina pectoris.Books on Demand GmbH, Überseering 33, 22297 Hamburg 64 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The objective of present study was to formulate an oral mcoadhesive tablet of diltiazem hydrochloride.Investigate the effect of amount of HPMC K4M and sodium alginate on the sustained release and gastric residence time of dosage form. The mucoadhesive tablet prepared by direct compression method was used varying concentrations of HPMC K4M and Sodium alginate and (1:1, 1:1.5, 1:2) Drug and Polymer ratio.The formulations were evaluated and results revealed that FTIR studies showed no evidence of interactions between drug and excipients used. The mucoadhesive strength, residence time and drug content of formulation F3 was found to be 26.35 ± 1.15 mg, >7.5hrs, and 98.75 ± 0.05 % respectively. The formulation F3 exhibited sustained drug release i.e. 75.71% in 12 h. The in vitro release kinetics studies reveal that formulations fit well with zero order kinetics and mechanism of drug release is Super case II transport. The study was concluded that formulation of mucoadhesive tablets from the cumulative % drug release study reveals that increase in the concentration of adhesive polymers cause slow the drug release. Tablet of DTZ can be beneficial in treatment of hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Englisch.

Taschenbuch. Zustand: Neu. Formulation, Design and Characterization of Mucoadhesive Buccal Film | Buccal Film | Anilkumar Shinde (u. a.) | Taschenbuch | 64 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9786139848171 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Neuware -The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it¿s oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it¿s crystalline nature, when compared with plain drug.Books on Demand GmbH, Überseering 33, 22297 Hamburg 64 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, self micro emulsification time and drug content determination. The optimized formulation exhibited 98 % in vitro drug release, which was significantly higher than that of the drug solution. Infrared spectroscopy, differential scanning calorimetric, SEM and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. From the stability studies of solid SMEDDS, there was no significant decrease in drug release and drug content, hence the formulation is found to be stable and then Comparative in vitro release study of optimised batch.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The objective of present study was to formulate an oral mcoadhesive tablet of diltiazem hydrochloride.Investigate the effect of amount of HPMC K4M and sodium alginate on the sustained release and gastric residence time of dosage form. The mucoadhesive tablet prepared by direct compression method was used varying concentrations of HPMC K4M and Sodium alginate and (1:1, 1:1.5, 1:2) Drug and Polymer ratio.The formulations were evaluated and results revealed that FTIR studies showed no evidence of interactions between drug and excipients used. The mucoadhesive strength, residence time and drug content of formulation F3 was found to be 26.35 ± 1.15 mg, >7.5hrs, and 98.75 ± 0.05 % respectively. The formulation F3 exhibited sustained drug release i.e. 75.71% in 12 h. The in vitro release kinetics studies reveal that formulations fit well with zero order kinetics and mechanism of drug release is Super case II transport. The study was concluded that formulation of mucoadhesive tablets from the cumulative % drug release study reveals that increase in the concentration of adhesive polymers cause slow the drug release. Tablet of DTZ can be beneficial in treatment of hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Norfloxacin and Tinidazole in pharmaceutical dosage forms. The first method involves determination using the AUC Method (Area Under Curve Method); the sampling wavelengths selected are 272-282 nm and 313-323 nm over the concentration ranges of 2-12¿g/mL and 3-18 ¿g/mL for Norfloxacin and Tinidazole respectively. The second method involves determination using the Q-Analysis Method (Absorbance Ratio Method); the sampling wavelengths selected are 277 nm and 318 nm over the concentration ranges of 2-12 ¿g/mL and 3-18 ¿g/mL for Norfloxacin and Tinidazole respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The present study was to maintain the levels of diltiazem hydrochloride within a desired range, reduction in its dosing frequency and increase bioavailability. The tablets were formulated by using of 32 factorial design, the effect of independent variables X1 (concentration of hydroxy propyl methylcellulose K100) and X2 (concentration of sodium carboxymethylcellulose) on swelling index and drug release was studied. Tablets were prepared by direct compression method using 13 mm punch on rotary tablet machine. Physical properties of compressed tablets such as hardness, friability, content uniformity, swelling index were determined. The swelling index of optimized batch varied between 114.21 and 220.41 %. The percentage drug release of optimized batch was 15.60% at 1 h and 71.97% at 12 h. From the drug release kinetic study, Peppas model was found to be best fit. Infrared spectrum showed that there was no interaction between drug and polymers in the formulation. The sustained drug release pattern was successfully achieved through the formulation of expandable gastroretentive tablets.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Biodegradable microspheres are one of the most useful devices to deliver materials in an effective, prolonged and safe manner. Mucoadhesion is a novel area of interest in the design of drug delivery systems to maintain the dosage form at the site of action or absorption and to facilitate intimate contact of the dosage form with underlying absorption surface to improve and enhance bioavailability. Repaglinide is a meglitinide analogue used as oral hypoglycaemic drug and having very low t1/2 (~ 1hr.), 56% bioavailability. It is totally absorbed from GIT, so it is the need to increase its transit time, by formulating with HPMC K4M, sodium alginate and Carbopol 934 P. Sodium alginate microspheres for an anti diabetic drug, repaglinide, were prepared by ionic-gelation method and investigated for its various physicochemical and release properties. Incorporation of HPMC K4M and Carbopol 934 P in the formulations affected the mucoadhesion, % water absorption, shape and release pattern of the formulations. Drug release from the microspheres followed peppas order kinetics. The prepared batches were found to sustained the release of the drug for 12 hours.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Englisch.

Zustand: New.

Taschenbuch. Zustand: Neu. Diclofenac Potassium Tablet for Colon Targeting: Formulation | Diclofenac Potassium Tablet for Colon Targeting | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2023 | LAP LAMBERT Academic Publishing | EAN 9786206181217 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Formulation, Development of Mesalamine Tablet for Colon Targeting | Mesalamine Tablet for Colon Targeting | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2024 | LAP LAMBERT Academic Publishing | EAN 9786208170691 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. DESIGN AND DEVELOPMENT OF MUCOADHESIVE MICROSPHERES | MUCOADHESIVE MICROSPHERES | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2022 | LAP LAMBERT Academic Publishing | EAN 9786200325891 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. FORMULATION OF MUCOAHESIVE GASTRORETENTIVE TABLET OF DILTIAZEM HYDROCHLORIDE | MUCOAHESIVE GASTRORETENTIVE TABLET | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2022 | LAP LAMBERT Academic Publishing | EAN 9786200431820 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. VALIDATION OF SPECTROPHOTOMETRIC METHODS | VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION IN COMBINED DOSAGE FORM | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2022 | LAP LAMBERT Academic Publishing | EAN 9786205498910 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement | Nanocrystals for Solubility and Dissolution | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2024 | LAP LAMBERT Academic Publishing | EAN 9786207640492 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery | Nitrendipin Self-Microemulsifying Drug Delivery System | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2023 | LAP LAMBERT Academic Publishing | EAN 9786207448104 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING | FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING | Anilkumar Shinde (u. a.) | Taschenbuch | Englisch | 2025 | LAP LAMBERT Academic Publishing | EAN 9786206739494 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Zustand: New.

Zustand: New.

Zustand: New.

Zustand: New.

Taschenbuch. Zustand: Neu. Neuware -The aim of the present study was to prepare microsponges gel formulation containing lornixicam by quasi emulsion solvent diffusion method. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges were spherical, uniform in shape, between 19 to 136¿m in diameter. The production yield, actual drug content and encapsulation efficiency was found in the range of 57.14±0.47 to 88.57±0.799%, 54.78±0.76 to 83.55±0.65%, and 65.73±0.35 % to 95.04±0.42 respectively. The results of compatibility studies FTIR, PXRD, DSC and accelerated stability studies showed that no chemical interaction with drug and excipients. The dermal observation of skin irritation study shows no sign of either erythema or edema after 24 hrs of application. In % inhibition was more in microsponges gel as compare with pure drug gel in anti- inflammatory activity. Formulation of lornoxicam microsponges provides better control over release of drug. This study presents a new approach based on microsponge drug delivery system for topical application.Books on Demand GmbH, Überseering 33, 22297 Hamburg 108 pp. Englisch.

Taschenbuch. Zustand: Neu. Formulation of Film Coated Tablets of Norfloxacin and Tinidazole | Anilkumar Shinde (u. a.) | Taschenbuch | 96 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9786139977369 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Taschenbuch. Zustand: Neu. Neuware -El objetivo del presente estudio fue formular un comprimido mucoadhesivo oral de clorhidrato de diltiazem e investigar el efecto de la cantidad de HPMC K4M y alginato de sodio en la liberación sostenida y el tiempo de residencia gástrica de la forma farmacéutica. El comprimido mucoadhesivo preparado por el método de compresión directa se utilizó variando las concentraciones de HPMC K4M y alginato de sodio y (1:1, 1:1,5, 1:2) la proporción de fármaco y polímero.Las formulaciones se evaluaron y los resultados revelaron que los estudios FTIR no mostraron evidencia de interacciones entre el fármaco y los excipientes utilizados. La fuerza mucoadhesiva, el tiempo de residencia y el contenido de fármaco de la formulación F3 resultaron ser 26,35 ± 1,15 mg, >7,5 horas y 98,75 ± 0,05 % respectivamente. La formulación F3 mostró una liberación sostenida del fármaco, es decir, un 75,71% en 12 h. Los estudios de la cinética de liberación in vitro revelan que las formulaciones se ajustan bien a la cinética de orden cero y el mecanismo de liberación del fármaco es el transporte de supercaso II. El estudio concluyó que la formulación de los comprimidos mucoadhesivos a partir del estudio de liberación acumulada del fármaco revela que el aumento de la concentración de polímeros adhesivos hace que la liberación del fármaco sea más lenta. Los comprimidos de DTZ pueden ser beneficiosos para el tratamiento de la hipertensión.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Spanisch.

Taschenbuch. Zustand: Neu. Neuware -El objetivo del sistema automicroemulsionable de administración de fármacos (SMEDDS) de nitrendipino era superar los problemas de solubilidad y biodisponibilidad deficientes. La estrategia de formulación incluía la selección de la fase oleosa a partir de estudios de solubilidad saturada y la selección de tensioactivos y cosurfactantes en función de su capacidad de emulsificación. Se construyeron diagramas de fases ternarias para identificar la región de autoemulsificación. Se concluyó que el oleato de etilo como aceite, el Cremophore RH40 como tensioactivo y el PEG 400 como co-tensioactivo eran componentes optimizados. La SMEDDS preparada se caracterizó por su tamaño de gota, potencial zeta, tiempo de auto-microemulsificación y determinación del contenido de fármaco. La formulación optimizada mostró una liberación in vitro del fármaco del 98%, significativamente superior a la de la solución del fármaco. Los estudios de espectroscopia infrarroja, calorimetría diferencial de barrido, SEM y difracción de rayos X indicaron que no había incompatibilidad entre el fármaco, el aceite y los tensioactivos. A partir de los estudios de estabilidad de los SMEDDS sólidos, no se observó una disminución significativa en la liberación del fármaco ni en el contenido de fármaco, por lo que se considera que la formulación es estable y, a continuación, se realiza un estudio comparativo de liberación in vitro del lote optimizado.Books on Demand GmbH, Überseering 33, 22297 Hamburg 56 pp. Spanisch.