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Hardcover. Zustand: Fine. Abnutzung / Risse - leicht; Vergilbt / ausgeblichen. Structural biology is increasingly becoming a standard technique for structure determination in the pharmaceutical industry. Advances in molecular biology, crystal handling, data collection, tunable synchrotron radiation sources, and high-performance computing have facilitated the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperatures. The Protein Databank has seen a remarkable increase in protein structure deposits, with over 1,500 structures submitted annually since 1997. In just the first seven months of this year, another 1,500 structures were added. Global initiatives in "structural genomics" have led to high-throughput structure determination techniques, further boosting the number of three-dimensional protein structures identified. This structural information plays a crucial role in drug discovery, being utilized not only in structure-based drug design for new low-molecular-weight ligands but also in the early stages of target validation and assessment. As the number of protein sequences lacking significant homology to known proteins grows, structure-sequence compatibility (threading) is increasingly employed to assign functions to specific protein folds.

Zustand: Good. 205 pp., Hardcover, ex library, else text clean and binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country.

Original-Pappband; 8°; XIII (I) 205 (5) Seiten. Sehr gutes Exemplar. Sprache: Englisch Ernst Schering Research Foundation Workshop 34. 450 gr.

Zustand: New. In.

Zustand: New.

Paperback. Zustand: Brand New. reprint edition. 224 pages. 8.26x5.82x0.50 inches. In Stock.

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Structural biology is becoming a routine technique for structure de termination in pharmaceutical industries. The advances in molecular biology, crystal handling and data collection techniques, tunable syn chrotron radiation sources, and high-performance computing have all contributed to developments such as the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperature. The number of protein structures deposited in the Protein Databank has increased tremendously over the last 3-4 years. Since 1997, more than 1,500 structures have been deposited each year, and during the first 7 months of this year, 1,500 protein structures were already deposited. The numerous initiatives in the field of 'structural genomics' distributed all over the world have led to the development of techniques for high-throughput structure determina tion, thereby contributing to the increase in the determination of three dimensional protein structures. This structural information is being ex plored in various ways in the drug discovery process. It is not only used in structure-based drug design of new low-molecular-weight li gands, but also in the early stages of target validation and assessment. With the number of protein sequences without significant homology to well-known proteins increasing, the technique of structure-sequence compatibility (threading) is increasingly used to assign a function to a given protein fold.

Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Keine Beschreibung verfügbar.